Search Results - "Lam, Maggie P Y"

Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions by Currie, Jordan, Manda, Vyshnavi, Robinson, Sean K., Lai, Celine, Agnihotri, Vertica, Hidalgo, Veronica, Ludwig, R. W., Zhang, Kai, Pavelka, Jay, Wang, Zhao V., Rhee, June-Wha, Lam, Maggie P. Y., Lau, Edward

“…The spatial and temporal distributions of proteins are critical to protein function, but cannot be directly assessed by measuring protein bundance. Here we…”
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Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners by Srivastava, Himangi, Lippincott, Michael J, Currie, Jordan, Canfield, Robert, Lam, Maggie P Y, Lau, Edward

“…Protein and mRNA levels correlate only moderately. The availability of proteogenomics data sets with protein and transcript measurements from matching samples…”
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The contribution of Alu exons to the human proteome by Lin, Lan, Jiang, Peng, Park, Juw Won, Wang, Jinkai, Lu, Zhi-Xiang, Lam, Maggie P Y, Ping, Peipei, Xing, Yi

“…Alu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high…”
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Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization by Lam, Maggie P. Y, Siu, S. O, Lau, Edward, Mao, Xiuli, Sun, H. Z, Chiu, Philip C. N, Yeung, William S. B, Cox, David M, Chu, Ivan K

“…We have developed a novel system for coupling reverse-phase (RP) and hydrophilic interaction liquid chromatography (HILIC) online in a micro-flow scheme. In…”
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Integrated omics dissection of proteome dynamics during cardiac remodeling by Lau, Edward, Cao, Quan, Lam, Maggie P. Y., Wang, Jie, Ng, Dominic C. M., Bleakley, Brian J., Lee, Jessica M., Liem, David A., Wang, Ding, Hermjakob, Henning, Ping, Peipei

“…Transcript abundance and protein abundance show modest correlation in many biological models, but how this impacts disease signature discovery in omics…”
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Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart by Dostal, Vishantie, Wood, Silas D., Thomas, Cody T., Han, Yu, Lau, Edward, Lam, Maggie P. Y.

“…The heart is sensitive to oxidative damage but a global view on how the cardiac proteome responds to oxidative stressors has yet to fully emerge. Using…”
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Proteomics Research in Cardiovascular Medicine and Biomarker Discovery by Lam, Maggie P.Y., PhD, Ping, Peipei, PhD, Murphy, Elizabeth, PhD

“…Abstract Proteomics is a systems physiology discipline to address the large-scale characterization of protein species within a biological system, be it a cell,…”
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Identifying High-Priority Proteins Across the Human Diseasome Using Semantic Similarity by Lau, Edward, Venkatraman, Vidya, Thomas, Cody T, Wu, Joseph C, Van Eyk, Jennifer E, Lam, Maggie P. Y

“…Identifying the genes and proteins associated with a biological process or disease is a central goal of the biomedical research enterprise. However, relatively…”
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Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems by Lam, Maggie P. Y, Venkatraman, Vidya, Xing, Yi, Lau, Edward, Cao, Quan, Ng, Dominic C. M, Su, Andrew I, Ge, Junbo, Van Eyk, Jennifer E, Ping, Peipei

“…Amidst the proteomes of human tissues lie subsets of proteins that are closely involved in conserved pathophysiological processes. Much of biomedical research…”
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Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics by Siu, S. O., Lam, Maggie P. Y., Lau, Edward, Kong, Ricky P. W., Lee, Simon M. Y., Chu, Ivan K.

“…Herein, we describe the development of a fully automatable technology that features online coupling of high‐pH RP separation with conventional low‐pH RP…”
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Mining the Proteome Associated with Rheumatic and Autoimmune Diseases by Ruiz-Romero, Cristina, Lam, Maggie P. Y, Nilsson, Peter, Önnerfjord, Patrik, Utz, Paul J, Van Eyk, Jennifer E, Venkatraman, Vidya, Fert-Bober, Justyna, Watt, Fiona E, Blanco, Francisco J

“…A steady increase in the incidence of osteoarthritis and other rheumatic diseases has been observed in recent decades, including autoimmune conditions such as…”
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Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart by Han, Yu, Wood, Silas D., Wright, Julianna M., Dostal, Vishantie, Lau, Edward, Lam, Maggie P.Y.

“…Alternative splicing is prevalent in the heart and implicated in many cardiovascular diseases, but not every alternative transcript is translated and detecting…”
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Harnessing the Power of Proteomics to Assess Drug Safety and Guide Clinical Trials by Lam, Maggie P Y, Ge, Ying

“…Assessing drug safety and efficacy is costly, and many promising candidates can present unwanted side effects. Can new developments in proteomic biomarkers…”
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Transcriptome features of striated muscle aging and predictability of protein level changes by Han, Yu, Li, Lauren Z, Kastury, Nikhitha L, Thomas, Cody T, Lam, Maggie P Y, Lau, Edward

“…We performed total RNA sequencing and multi-omics analysis comparing skeletal muscle and cardiac muscle in young adult (4 months) early aging (20 months) mice…”
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Substrate- and Isoform-Specific Proteome Stability in Normal and Stressed Cardiac Mitochondria by Lau, Edward, Wang, Ding, Zhang, Jun, Yu, Hongxiu, Lam, Maggie P.Y, Liang, Xiangbo, Zong, Nobel, Kim, Tae-Young, Ping, Peipei

“…RATIONALE:Mitochondrial protein homeostasis is an essential component of the functions and oxidative stress responses of the heart. OBJECTIVE:To determine the…”
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Cardiovascular proteomics in the era of big data: experimental and computational advances by Lam, Maggie P Y, Lau, Edward, Ng, Dominic C M, Wang, Ding, Ping, Peipei

“…Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past…”
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Seeking clarity on sex differences in cardiovascular complications of Down syndrome by Lam, Maggie P Y

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Prioritizing Proteomics Assay Development for Clinical Translation by Lam, Maggie P.Y., PhD, Venkatraman, Vidya, MSc, Cao, Quan, MD, PhD, Wang, Ding, PhD, Dincer, T. Umut, MSc, Lau, Edward, PhD, Su, Andrew I., PhD, Xing, Yi, PhD, Ge, Junbo, MD, Ping, Peipei, PhD, Van Eyk, Jennifer E., PhD

“…Assay Human Mouse 1 532 P16860 NPPB Natriuretic peptides B Secreted heart failure marker * * 2 379 P12821 ACE Angiotensin-converting enzyme Vasoconstrictor…”
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Characterization of human plasma proteome dynamics using deuterium oxide by Wang, Ding, Liem, David A., Lau, Edward, Ng, Dominic C. M., Bleakley, Brian J., Cadeiras, Martin, Deng, Mario C., Lam, Maggie P. Y., Ping, Peipei

“…Purpose High‐throughput quantification of human protein turnover via in vivo administration of deuterium oxide (2H2O) is a powerful new approach to examine…”
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Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples by Lam, Maggie P. Y., Lau, Edward, Siu, S. O., Ng, Dominic C. M., Kong, Ricky P. W., Chiu, Philip C. N., Yeung, William S. B., Lo, Clive, Chu, Ivan K.

“…In this paper, we describe an online combination of reversed‐phase/reversed‐phase (RP–RP) and porous graphitic carbon (PGC) liquid chromatography (LC) for…”
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