Search Results - "Lam, Lucia L"

Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy by Seiler, Roland, Ashab, Hussam Al Deen, Erho, Nicholas, van Rhijn, Bas W.G, Winters, Brian, Douglas, James, Van Kessel, Kim E, Fransen van de Putte, Elisabeth E, Sommerlad, Matthew, Wang, Natalie Q, Choeurng, Voleak, Gibb, Ewan A, Palmer-Aronsten, Beatrix, Lam, Lucia L, Buerki, Christine, Davicioni, Elai, Sjödahl, Gottfrid, Kardos, Jordan, Hoadley, Katherine A, Lerner, Seth P, McConkey, David J, Choi, Woonyoung, Kim, William Y, Kiss, Bernhard, Thalmann, George N, Todenhöfer, Tilman, Crabb, Simon J, North, Scott, Zwarthoff, Ellen C, Boormans, Joost L, Wright, Jonathan, Dall’Era, Marc, van der Heijden, Michiel S, Black, Peter C

“…Abstract Background An early report on the molecular subtyping of muscle-invasive bladder cancer (MIBC) by gene expression suggested that response to…”
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Factors underlying variable DNA methylation in a human community cohort by Lam, Lucia L., Emberly, Eldon, Fraser, Hunter B., Neumann, Sarah M., Chen, Edith, Miller, Gregory E., Kobor, Michael S.

“…Epigenetics is emerging as an attractive mechanism to explain the persistent genomic embedding of early-life experiences. Tightly linked to chromatin, which…”
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Population-specificity of human DNA methylation by Fraser, Hunter B, Lam, Lucia L, Neumann, Sarah M, Kobor, Michael S

“…Ethnic differences in human DNA methylation have been shown for a number of CpG sites, but the genome-wide patterns and extent of these differences are largely…”
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Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study by Lalonde, Emilie, MSc, Ishkanian, Adrian S, MD, Sykes, Jenna, MMath, Fraser, Michael, PhD, Ross-Adams, Helen, PhD, Erho, Nicholas, MSc, Dunning, Mark J, PhD, Halim, Silvia, MSc, Lamb, Alastair D, FRCS, Moon, Nathalie C, MMath, Zafarana, Gaetano, PhD, Warren, Anne Y, FRCPath, Meng, Xianyue, MSc, Thoms, John, MD, Grzadkowski, Michal R, BMath, Berlin, Alejandro, MD, Have, Cherry L, BSc, Ramnarine, Varune R, BCS, Yao, Cindy Q, MSc, Malloff, Chad A, MSc, Lam, Lucia L, BSc, Xie, Honglei, MMath, Harding, Nicholas J, PhD, Mak, Denise Y F, PhD, Chu, Kenneth C, PhD, Chong, Lauren C, BCS, Sendorek, Dorota H, BSc, P'ng, Christine, BSc, Collins, Colin C, Prof, Squire, Jeremy A, Prof, Jurisica, Igor, Prof, Cooper, Colin, PhD, Eeles, Rosalind, Prof, Pintilie, Melania, MSc, Dal Pra, Alan, MD, Davicioni, Elai, PhD, Lam, Wan L, Prof, Milosevic, Michael, MD, Neal, David E, Prof, van der Kwast, Theodorus, Prof, Boutros, Paul C, Prof, Bristow, Robert G, Prof

“…Summary Background Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided…”
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Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array by Price, Magda E, Cotton, Allison M, Lam, Lucia L, Farré, Pau, Emberly, Eldon, Brown, Carolyn J, Robinson, Wendy P, Kobor, Michael S

“…Measurement of genome-wide DNA methylation (DNAm) has become an important avenue for investigating potential physiologically-relevant epigenetic changes…”
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Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation by Rush, Margaret, Appanah, Ruth, Lee, Sandra, Lam, Lucia L., Goyal, Preeti, Lorincz, Matthew C.

“…Polycomb-mediated gene silencing and DNA methylation underlie many epigenetic processes important in normal development as well as in cancer. An interaction…”
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Reply to Suderman et al.: Importance of accounting for blood cell composition in epigenetic studies by Lam, Lucia L, Emberly, Eldon, Fraser, Hunter B, Neumann, Sarah M, Chen, Edith, Miller, Gregory E, Kobor, Michael S

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Epigenetic Vestiges of Early Developmental Adversity: Childhood Stress Exposure and DNA Methylation in Adolescence by Essex, Marilyn J., Thomas Boyce, W., Hertzman, Clyde, Lam, Lucia L., Armstrong, Jeffrey M., Neumann, Sarah M. A., Kobor, Michael S.

“…Fifteen-year-old adolescents (N = 109) in a longitudinal study of child development were recruited to examine differences in DNA methylation in relation to…”
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Individual Patient-Level Meta-Analysis of the Performance of the Decipher Genomic Classifier in High-Risk Men After Prostatectomy to Predict Development of Metastatic Disease by Spratt, Daniel E, Yousefi, Kasra, Deheshi, Samineh, Ross, Ashley E, Den, Robert B, Schaeffer, Edward M, Trock, Bruce J, Zhang, Jingbin, Glass, Andrew G, Dicker, Adam P, Abdollah, Firas, Zhao, Shuang G, Lam, Lucia L C, du Plessis, Marguerite, Choeurng, Voleak, Haddad, Zaid, Buerki, Christine, Davicioni, Elai, Weinmann, Sheila, Freedland, Stephen J, Klein, Eric A, Karnes, R Jeffrey, Feng, Felix Y

“…Purpose To perform the first meta-analysis of the performance of the genomic classifier test, Decipher, in men with prostate cancer postprostatectomy. Methods…”
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Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men by Ross, Ashley E, Johnson, Michael H, Yousefi, Kasra, Davicioni, Elai, Netto, George J, Marchionni, Luigi, Fedor, Helen L, Glavaris, Stephanie, Choeurng, Voleak, Buerki, Christine, Erho, Nicholas, Lam, Lucia L, Humphreys, Elizabeth B, Faraj, Sheila, Bezerra, Stephania M, Han, Misop, Partin, Alan W, Trock, Bruce J, Schaeffer, Edward M

“…Abstract Background Radical prostatectomy (RP) is a primary treatment option for men with intermediate- and high-risk prostate cancer. Although many are…”
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Decipher Genomic Classifier Measured on Prostate Biopsy Predicts Metastasis Risk by Klein, Eric A, Haddad, Zaid, Yousefi, Kasra, Lam, Lucia L.C, Wang, Qiqi, Choeurng, Voleak, Palmer-Aronsten, Beatrix, Buerki, Christine, Davicioni, Elai, Li, Jianbo, Kattan, Michael W, Stephenson, Andrew J, Magi-Galluzzi, Cristina

“…Objectives To evaluate the ability of the Decipher genomic classifier in predicting metastasis from analysis of prostate needle biopsy diagnostic tumor tissue…”
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Validation of a genomic classifier that predicts metastasis following radical prostatectomy in an at risk patient population by Karnes, R Jeffrey, Bergstralh, Eric J, Davicioni, Elai, Ghadessi, Mercedeh, Buerki, Christine, Mitra, Anirban P, Crisan, Anamaria, Erho, Nicholas, Vergara, Ismael A, Lam, Lucia L, Carlson, Rachel, Thompson, Darby J S, Haddad, Zaid, Zimmermann, Benedikt, Sierocinski, Thomas, Triche, Timothy J, Kollmeyer, Thomas, Ballman, Karla V, Black, Peter C, Klee, George G, Jenkins, Robert B

“…Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is…”
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Prediction of Lymph Node Metastasis in Patients with Bladder Cancer Using Whole Transcriptome Gene Expression Signatures by Seiler, Roland, Lam, Lucia L, Erho, Nicholas, Takhar, Mandeep, Mitra, Anirban P, Buerki, Christine, Davicioni, Elai, Skinner, Eila C, Daneshmand, Siamak, Black, Peter C

“…Purpose Clinical staging in patients with muscle invasive bladder cancer misses up to 25% of lymph node metastasis. These patients are at high risk for disease…”
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Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy by Freedland, Stephen J, Choeurng, Voleak, Howard, Lauren, De Hoedt, Amanda, du Plessis, Marguerite, Yousefi, Kasra, Lam, Lucia L, Buerki, Christine, Ra, Seong, Robbins, Bruce, Trabulsi, Edouard J, Shah, Nikhil L, Abdollah, Firas, Feng, Felix Y, Davicioni, Elai, Dicker, Adam P, Karnes, Robert J, Den, Robert B

“…Abstract Background Despite salvage radiation therapy (SRT) for recurrent prostate cancer (PCa) after radical prostatectomy (RP), some patients still progress…”
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Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies by Stoyanova, Radka, Pollack, Alan, Takhar, Mandeep, Lynne, Charles, Parra, Nestor, Lam, Lucia L C, Alshalalfa, Mohammed, Buerki, Christine, Castillo, Rosa, Jorda, Merce, Ashab, Hussam Al-Deen, Kryvenko, Oleksandr N, Punnen, Sanoj, Parekh, Dipen J, Abramowitz, Matthew C, Gillies, Robert J, Davicioni, Elai, Erho, Nicholas, Ishkanian, Adrian

“…Standard clinicopathological variables are inadequate for optimal management of prostate cancer patients. While genomic classifiers have improved patient risk…”
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Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens by Nguyen, Paul L, Haddad, Zaid, Ross, Ashley E, Martin, Neil E, Deheshi, Samineh, Lam, Lucia L.C, Chelliserry, Jijumon, Tosoian, Jeffrey J, Lotan, Tamara L, Spratt, Daniel E, Stoyanova, Radka S, Punnen, Sanoj, Ong, Kaye, Buerki, Christine, Aranes, Maria, Kolisnik, Tyler, Margrave, Jennifer, Yousefi, Kasra, Choeurng, Voleak, Davicioni, Elai, Trock, Bruce J, Kane, Christopher J, Pollack, Alan, Davis, John W, Feng, Felix Y, Klein, Eric A

“…Abstract Background Decipher is a validated genomic classifier developed to determine the biological potential for metastasis after radical prostatectomy (RP)…”
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Spread of X-chromosome inactivation into autosomal sequences: role for DNA elements, chromatin features and chromosomal domains by Cotton, Allison M, Chen, Chih-Yu, Lam, Lucia L, Wasserman, Wyeth W, Kobor, Michael S, Brown, Carolyn J

“…X-chromosome inactivation results in dosage equivalence between the X chromosome in males and females; however, over 15% of human X-linked genes escape…”
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Validation of the Decipher Test for predicting adverse pathology in candidates for prostate cancer active surveillance by Kim, Hyung L., Li, Ping, Huang, Huei-Chung, Deheshi, Samineh, Marti, Tara, Knudsen, Beatrice, Abou-Ouf, Hatem, Alam, Ridwan, Lotan, Tamara L., Lam, Lucia L. C., du Plessis, Marguerite, Davicioni, Elai, Fleshner, Neil, Lane, Brian R., Ross, Ashley E., Davis, John W., Mohler, James L., Trock, Bruce J., Klein, Eric A., Tosoian, Jeffrey J., Hyndman, M. Eric, Bismar, Tarek A.

“…Abstact Background Many men diagnosed with prostate cancer are active surveillance (AS) candidates. However, AS may be associated with increased risk of…”
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DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity by Dong, Kevin B, Maksakova, Irina A, Mohn, Fabio, Leung, Danny, Appanah, Ruth, Lee, Sandra, Yang, Hao W, Lam, Lucia L, Mager, Dixie L, Schübeler, Dirk, Tachibana, Makoto, Shinkai, Yoichi, Lorincz, Matthew C

“…Histone H3K9 methylation is required for DNA methylation and silencing of repetitive elements in plants and filamentous fungi. In mammalian cells however,…”
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Discovery and Validation of Novel Expression Signature for Postcystectomy Recurrence in High-Risk Bladder Cancer by MITRA, Anirban P, LAM, Lucia L, SKINNER, Eila C, DAVICIONI, Elai, DANESHMAND, Siamak, BLACK, Peter C, GHADESSI, Mercedeh, ERHO, Nicholas, VERGARA, Ismael A, ALSHALALFA, Mohammed, BUERKI, Christine, HADDAD, Zaid, SIEROCINSKI, Thomas, TRICHE, Timothy J

“…Nearly half of muscle-invasive bladder cancer patients succumb to their disease following cystectomy. Selecting candidates for adjuvant therapy is currently…”
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