Search Results - "Lam, Kit S."

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles by Xiao, Kai, Li, Yuanpei, Luo, Juntao, Lee, Joyce S, Xiao, Wenwu, Gonik, Abby M, Agarwal, Rinki G, Lam, Kit S

“…Abstract To systematically elucidate the effect of surface charge on the cellular uptake and in vivo fate of PEG-oligocholic acid based micellar nanoparticles…”
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A smart and versatile theranostic nanomedicine platform based on nanoporphyrin by Li, Yuanpei, Lin, Tzu-yin, Luo, Yan, Liu, Qiangqiang, Xiao, Wenwu, Guo, Wenchang, Lac, Diana, Zhang, Hongyong, Feng, Caihong, Wachsmann-Hogiu, Sebastian, Walton, Jeffrey H., Cherry, Simon R., Rowland, Douglas J., Kukis, David, Pan, Chongxian, Lam, Kit S.

“…Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining…”
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Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion by Jiang, Nian, Xie, Bowen, Xiao, Wenwu, Fan, Ming, Xu, Shanxiu, Duan, Yixin, Hamsafar, Yamah, Evans, Angela C., Huang, Jie, Zhou, Weibing, Lin, Xuelei, Ye, Ningrong, Wanggou, Siyi, Chen, Wen, Jing, Di, Fragoso, Ruben C., Dugger, Brittany N., Wilson, Paul F., Coleman, Matthew A., Xia, Shuli, Li, Xuejun, Sun, Lun-Quan, Monjazeb, Arta M., Wang, Aijun, Murphy, William J., Kung, Hsing-Jien, Lam, Kit S., Chen, Hong-Wu, Li, Jian Jian

“…Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of…”
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Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass by Guan, Min, Yao, Wei, Liu, Ruiwu, Lam, Kit S, Nolta, Jan, Jia, Junjing, Panganiban, Brian, Meng, Liping, Zhou, Ping, Shahnazari, Mohammad, Ritchie, Robert O, Lane, Nancy E

“…Targeting mesenchymal stem cells (MSCs), progenitors of osteoblasts, to bone has been a long-standing goal but has had limited success so far. Here, Min Guan…”
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RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype by Cai, Demin, Wang, Junjian, Gao, Bei, Li, Jin, Wu, Feng, Zou, June X., Xu, Jianzhen, Jiang, Yuqian, Zou, Hongye, Huang, Zenghong, Borowsky, Alexander D., Bold, Richard J., Lara, Primo N., Li, Jian Jian, Chen, Xinbin, Lam, Kit S., To, Ka-Fai, Kung, Hsing-Jien, Fiehn, Oliver, Zhao, Ruqian, Evans, Ronald M., Chen, Hong-Wu

“…Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC)…”
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Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells by Candas-Green, Demet, Xie, Bowen, Huang, Jie, Fan, Ming, Wang, Aijun, Menaa, Cheikh, Zhang, Yanhong, Zhang, Lu, Jing, Di, Azghadi, Soheila, Zhou, Weibing, Liu, Lin, Jiang, Nian, Li, Tao, Gao, Tianyi, Sweeney, Colleen, Shen, Rulong, Lin, Tzu-yin, Pan, Chong-xian, Ozpiskin, Omer M., Woloschak, Gayle, Grdina, David J., Vaughan, Andrew T., Wang, Ji Ming, Xia, Shuli, Monjazeb, Arta M., Murphy, William J., Sun, Lun-Quan, Chen, Hong-Wu, Lam, Kit S., Weichselbaum, Ralph R., Li, Jian Jian

“…Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells…”
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3D plasmonic nanobowl platform for the study of exosomes in solution by Lee, Changwon, Carney, Randy P, Hazari, Sidhartha, Smith, Zachary J, Knudson, Alisha, Robertson, Christopher S, Lam, Kit S, Wachsmann-Hogiu, Sebastian

“…Thin silver film coated nanobowl Surface Enhanced Raman Spectroscopy (SERS) substrates are used to capture exosomes in solution for SERS measurements that can…”
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Multispectral Optical Tweezers for Biochemical Fingerprinting of CD9-Positive Exosome Subpopulations by Carney, Randy P, Hazari, Sidhartha, Colquhoun, Macalistair, Tran, Di, Hwang, Billanna, Mulligan, Michael S, Bryers, James D, Girda, Eugenia, Leiserowitz, Gary S, Smith, Zachary J, Lam, Kit S

“…Extracellular vesicles (EVs), including exosomes, are circulating nanoscale particles heavily implicated in cell signaling and can be isolated in vast numbers…”
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Rapid discovery of self-assembling peptides with one-bead one-compound peptide library by Yang, Pei-Pei, Li, Yi-Jing, Cao, Yan, Zhang, Lu, Wang, Jia-Qi, Lai, Ziwei, Zhang, Kuo, Shorty, Diedra, Xiao, Wenwu, Cao, Hui, Wang, Lei, Wang, Hao, Liu, Ruiwu, Lam, Kit S.

“…Self-assembling peptides have shown tremendous potential in the fields of material sciences, nanoscience, and medicine. Because of the vast combinatorial space…”
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HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells by DURU, Nadire, MING FAN, SHIYONG LI, SPITZ, Douglas R, LAM, Kit S, WICHA, Max S, JIAN JIAN LI, CANDAS, Demet, MENAA, Cheikh, LIU, Hsin-Chen, NANTAJIT, Danupon, YUNFEI WEN, KAI XIAO, ELDRIDGE, Angela, CHROMY, Brett A

“…To understand the role of HER2-associated signaling network in breast cancer stem cells (BCSC) using radioresistant breast cancer cells and clinical recurrent…”
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Identification of osteogenic progenitor cell-targeted peptides that augment bone formation by Jiang, Min, Liu, Ruiwu, Liu, Lixian, Kot, Alexander, Liu, Xueping, Xiao, Wenwu, Jia, Junjing, Li, Yuanpei, Lam, Kit S., Yao, Wei

“…Activation and migration of endogenous mesenchymal stromal cells (MSCs) are critical for bone regeneration. Here, we report a combinational peptide screening…”
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A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells by Hu, Michelle, Liu, Ruiwu, Castro, Noemi, Loza Sanchez, Liliana, Rueankham, Lapamas, Learn, Julie A., Huang, Ruiqi, Lam, Kit S., Carraway, Kermit L.

“…Derivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have the capacity to…”
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Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization by Hao, Dake, Swindell, Hila Shimshi, Ramasubramanian, Lalithasri, Liu, Ruiwu, Lam, Kit S, Farmer, Diana L, Wang, Aijun

“…The network structure and biological components of natural extracellular matrix (ECM) are indispensable for promoting tissue regeneration. Electrospun…”
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A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer by Xiao, Kai, Luo, Juntao, Fowler, Wiley L, Li, Yuanpei, Lee, Joyce S, Xing, Li, Cheng, R. Holland, Wang, Li, Lam, Kit S

“…Abstract Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs for the treatment of a variety of cancers. However, it is associated with serious…”
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Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing by He, Siqi, Walimbe, Tanaya, Chen, Hongyuan, Gao, Kewa, Kumar, Priyadarsini, Wei, Yifan, Hao, Dake, Liu, Ruiwu, Farmer, Diana L., Lam, Kit S., Zhou, Jianda, Panitch, Alyssa, Wang, Aijun

“…Diabetic ischemic wound treatment remains a critical clinical challenge. Neovascularization plays a significant role in wound healing during all stages of the…”
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Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling by Jian, Zhong, Han, Huilan, Zhang, Tieqiao, Puglisi, Jose, Izu, Leighton T, Shaw, John A, Onofiok, Ekama, Erickson, Jeffery R, Chen, Yi-Je, Horvath, Balazs, Shimkunas, Rafael, Xiao, Wenwu, Li, Yuanpei, Pan, Tingrui, Chan, James, Banyasz, Tamas, Tardiff, Jil C, Chiamvimonvat, Nipavan, Bers, Donald M, Lam, Kit S, Chen-Izu, Ye

“…Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system…”
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Combinatorial chemistry in drug discovery by Liu, Ruiwu, Li, Xiaocen, Lam, Kit S

“…Several combinatorial methods have been developed to create focused or diverse chemical libraries with a wide range of linear or macrocyclic chemical…”
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High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer by Xiao, Wenwu, Ma, Weijie, Wei, Sixi, Li, Qianping, Liu, Ruiwu, Carney, Randy P, Yang, Kevin, Lee, Joyce, Nyugen, Alan, Yoneda, Ken Y, Lam, Kit S, Li, Tianhong

“…α3β1 integrin is a promising cancer biomarker and drug target. We previously identified a 9-amino-acid cyclic peptide LXY30 for detecting α3β1 integrin on the…”
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HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy by Lin, Tzu-Yin, Guo, Wenchang, Long, Qilai, Ma, Aihong, Liu, Qiangqiang, Zhang, Hongyong, Huang, Yee, Chandrasekaran, Siddarth, Pan, Chongxian, Lam, Kit S, Li, Yuanpei

“…Photodynamic therapy (PDT) is a promising non-invasive therapeutic modality that has been proposed for treating prostate cancer, but the procedure is…”
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Reversing bone loss by directing mesenchymal stem cells to bone by Yao, Wei, Guan, Min, Jia, Junjing, Dai, Weiwei, Lay, Yu‐An E., Amugongo, Sarah, Liu, Ruiwu, Olivos, David, Saunders, Mary, Lam, Kit S., Nolta, Jan, Olvera, Diana, Ritchie, Robert O., Lane, Nancy E.

“…Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is problematic due to the inability to control the MSCs' commitment, growth, and…”
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