Search Results - "Lam, Kevin W"

MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells by Pang, Ronald T.K., Leung, Carmen O.N., Ye, Tian-Min, Liu, Weimin, Chiu, Philip C.N., Lam, Kevin K.W., Lee, Kai-Fai, Yeung, William S.B.

“…MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of other genes by transcriptional inhibition or translational repression. miR-34a is…”
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Adrenomedullin Regulates Sperm Motility and Oviductal Ciliary Beat via Cyclic Adenosine 5′-Monophosphate/Protein Kinase A and Nitric Oxide by Chiu, Philip C. N, Liao, S, Lam, Kevin K. W, Tang, F, Ho, James C. M, Ho, P. C, O, W. S, Yao, Y. Q, Yeung, William S. B

“…Cilium and flagellum beating are important in reproduction and defects in their motion are associated with ectopic pregnancy and infertility. Adrenomedullin…”
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Glycodelin-A as a paracrine regulator in early pregnancy by Lee, Cheuk-Lun, Lam, Kevin K.W, Koistinen, Hannu, Seppala, Markku, Kurpisz, Maciej, Fernandez, Nelson, Pang, Ronald T.K, Yeung, William S.B, Chiu, Philip C.N

“…Abstract Glycodelin-A (GdA) is a glycoprotein secreted from the endometrial glands and decidual glandular epithelium. Given its abundance and ubiquitous…”
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Optimizing non-invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non-invasive PGT-A results by Chow, Judy F. C., Lam, Kevin K. W., Cheng, Heidi H. Y., Lai, Shui Fan, Yeung, William S. B., Ng, Ernest H. Y.

“…Purpose This study aimed to optimize the non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) in the laboratory by comparing two collection…”
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Simulating nature in sperm selection for assisted reproduction by Leung, Erica T. Y., Lee, Cheuk-Lun, Tian, Xinyi, Lam, Kevin K. W., Li, Raymond H. W., Ng, Ernest H. Y., Yeung, William S. B., Chiu, Philip C. N.

“…Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000 sperm out of millions in an ejaculate reach the fallopian tube and…”
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Correction to: Optimizing non‑invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non‑invasive PGT‑A results by Chow, Judy F. C., Lam, Kevin K. W., Cheng, Heidi H. Y., Lai, Shui Fan, Yeung, William S. B., Ng, Ernest H. Y.

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Effects of Differential Glycosylation of Glycodelins on Lymphocyte Survival by Lee, Cheuk-Lun, Pang, Poh-Choo, Yeung, William S.B., Tissot, Bérangère, Panico, Maria, Lao, Terence T.H., Chu, Ivan K., Lee, Kai-Fai, Chung, Man-Kin, Lam, Kevin K.W., Koistinen, Riitta, Koistinen, Hannu, Seppälä, Markku, Morris, Howard R., Dell, Anne, Chiu, Philip C.N.

“…Glycodelin is a human glycoprotein with four reported glycoforms, namely glycodelin-A (GdA), glycodelin-F (GdF), glycodelin-C (GdC), and glycodelin-S (GdS)…”
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Randomised double-blind controlled trial of non-invasive preimplantation genetic testing for aneuploidy in in vitro fertilisation: a protocol paper by Cheng, Hiu Yee Heidi, Chow, Judy F C, Lam, Kevin K W, Lai, Shui Fan, Yeung, William Shu Biu, Ng, Ernest H Y

“…The success rate of in vitro fertilisation (IVF) treatment for couples with infertility remains low due to lack of a reliable tool in selecting euploid embryos…”
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Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx by Chiu, Philip C.N., Wong, Ben S.T., Lee, Cheuk-Lun, Lam, Kevin K.W., Chung, Man-Kin, Lee, Kai-Fai, Koistinen, Riitta, Koistinen, Hannu, Gupta, Satish K., Seppälä, Markku, Yeung, William S.B.

“…BACKGROUND Glycodelin-A interacts with spermatozoa before fertilization, but its role in modulating sperm functions is not known. Zona pellucida-induced…”
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The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans by Leung, Erica T Y, Lee, Brayden K M, Lee, Cheuk-Lun, Tian, Xinyi, Lam, Kevin K W, Li, Raymond H W, Ng, Ernest H Y, Yeung, William S B, Ou, Jian-Ping, Chiu, Philip C N

“…Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction…”
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The Pleiotropic Effect of Glycodelin-A in Early Pregnancy by Lee, Cheuk-Lun, Lam, Kevin K. W., Vijayan, Madhavi, Koistinen, Hannu, Seppala, Markku, Ng, Ernest H. Y., Yeung, William S. B., Chiu, Philip C. N.

“…Successful pregnancy depends largely on adequate placentation and maternal tolerance of the fetus. Glycodelin‐A is a glycoprotein abundant in the decidua…”
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Effects of Native Human Zona Pellucida Glycoproteins 3 and 4 on Acrosome Reaction and Zona Pellucida Binding of Human Spermatozoa by Chiu, Philip C. N, Wong, Ben S. T, Chung, Man-Kin, Lam, Kevin K. W, Pang, Ronald T. K, Lee, Kai-Fai, Sumitro, S. B, Gupta, S. K, Yeung, William S. B

“…Acrosome reaction is crucial to the penetration of spermatozoa through the zona pellucida (ZP). Glycosylation of ZP glycoproteins is important in…”
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Naked-Eye Detection of Reversible Protein Folding and Unfolding in Aqueous Solution by Carlson, Tess M, Lam, Kevin W, Lam, Carol W, He, Jimmy Z, Maynard, James H, Cavagnero, Silvia

“…Students learning general chemistry and biochemistry often have difficulties understanding that proteins routinely exist in both folded and unfolded states,…”
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Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage by Huang, Venus Wenxin, Lee, Cheuk-Lun, Lee, Yin-Lau, Lam, Kevin K W, Ko, Jennifer K Y, Yeung, William S B, Ho, Pak-Chung, Chiu, Philip C N

“…Oxidative damage by reactive oxygen species (ROS) is a major cause of sperm dysfunction. Excessive ROS generation reduces fertilization and enhances DNA damage…”
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Glycodelin-A modulates cytokine production of peripheral blood natural killer cells by Lee, Cheuk-Lun, Ph.D, Chiu, Philip C.N., Ph.D, Lam, Kevin K.W., B.Sc, Chan, Rachel W.S., Ph.D, Chu, Ivan K., Ph.D, Koistinen, Riitta, Ph.D, Koistinen, Hannu, D.Sc, Seppälä, Markku, M.D., Ph.D, Lee, Kai-Fai, Ph.D, Yeung, William S.B., Ph.D

“…Glycodelin-A increased the secretion of interleukin-6, interleukin-13, and granulocyte-macrophage colony-stimulating factor from natural killer cells in the…”
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The role of galectin-3 in spermatozoa-zona pellucida binding and its association with fertilization in vitro by Mei, Si, Chen, Panyu, Lee, Cheuk-Lun, Zhao, Weie, Wang, Ying, Lam, Kevin K W, Ho, Pak-Chung, Yeung, William S B, Fang, Cong, Chiu, Philip C N

“…Abstract Human spermatozoa can fertilize an oocyte only after post-testicular maturation and capacitation. These processes involve dynamic modification and…”
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A retrospective analysis of artificial oocyte activation in patients with low or no fertilisation in intracytoplasmic sperm injection cycles by Lam, Kevin K. W., Wong, Jacki Y. Y., Cheung, Tak-Ming, Li, Raymond H. W., Ng, Ernest H. Y., Yeung, William S. B.

“…Intracytoplasmic sperm injection (ICSI) is commonly used to treat severe male factor infertility in assisted reproduction. A small percentage of patients face…”
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Glycodelin-A stimulates the conversion of human peripheral blood CD16−CD56bright NK cell to a decidual NK cell-like phenotype by Lee, Cheuk-Lun, Vijayan, Madhavi, Wang, Xia, Lam, Kevin K W, Koistinen, Hannu, Seppala, Markku, Li, Raymond H W, Ng, Ernest H Y, Yeung, William S B, Chiu, Philip C N

“…Abstract STUDY QUESTION Does glycodelin-A (GdA) induce conversion of human peripheral blood CD16−CD56bright natural killer (NK) cells to decidual NK (dNK)…”
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The roles of protein disulphide isomerase family A, member 3 (ERp57) and surface thiol/disulphide exchange in human spermatozoa–zona pellucida binding by Wong, Chi-Wai, Lam, Kevin K.W., Lee, Cheuk-Lun, Yeung, William S.B., Zhao, Wei E., Ho, Pak-Chung, Ou, Jian-Ping, Chiu, Philip C.N.

“…Abstract STUDY QUESTION Are multimeric sperm plasma membrane protein complexes, ERp57 and sperm surface thiol content involved in human spermatozoa–zona…”
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Glycodelin-A Protein Interacts with Siglec-6 Protein to Suppress Trophoblast Invasiveness by Down-regulating Extracellular Signal-regulated Kinase (ERK)/c-Jun Signaling Pathway by Lam, Kevin K.W., Chiu, Philip C.N., Lee, Cheuk-Lun, Pang, Ronald T.K., Leung, Carmen O.N., Koistinen, Hannu, Seppala, Markku, Ho, Pak-Chung, Yeung, William S.B.

“…During placentation, the cytotrophoblast differentiates into the villous cytotrophoblast and the extravillous cytotrophoblast. The latter invades the…”
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