Search Results - "Lam, Kelvin T."

A new chemical tool for exploring the physiological function of the PDE2 isozyme by Chambers, Robert J., Abrams, Kristin, Garceau, Norman Y., Kamath, Ajith V., Manley, Christopher M., Lilley, Susan C., Otte, Douglas A., Scott, Dennis O., Sheils, Alissa L., Tess, David A., Vellekoop, A. Samuel, Zhang, Yan, Lam, Kelvin T.

“…Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in…”
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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function by Chambers, Robert J., Abrams, Kristin, Castleberry, Tessa A., Cheng, John B., Fisher, Douglas A., Kamath, Ajith V., Marfat, Anthony, Nettleton, David O., Pillar, Joann D., Salter, Eben D., Sheils, Alissa L., Shirley, John T., Turner, Claudia R., Umland, John P., Lam, Kelvin T.

“…Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis…”
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Germ-Line Mutations of the p53 Tumor Suppressor Gene in Patients With High Risk for Cancer Inactivate the p53 Protein by Frebourg, Thierry, Kassel, Jayne, Lam, Kelvin T., Gryka, Magdalena A., Barbier, Noele, Andersen, Tone Ikdahl, Borresen, Anne-Lise, Friend, Stephen H.

“…Germ-line mutations in the p53 tumor suppressor gene have been observed in patients with Li-Fraumeni syndrome, brain tumors, second malignancies, and breast…”
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hsp70 binds specifically to a peptide derived from the highly conserved domain (I) region of p53 by Lam, K T, Calderwood, S K

“…Products of a number of mutant p53 genes bind with high affinity to members of the hsp70 family of chaperonin proteins, whereas wild type p53 lacks this type…”
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Structure and expression of the Xenopus retinoblastoma gene by Destrée, Olivier H.J., Lam, Kelvin T., Peterson-Maduro, L.Joselin, Eizema, Karin, Diller, Lisa, Gryka, Magdalena A., Frebourg, Thierry, Shibuya, Ellen, Friend, Stephen H.

“…We have cloned a Xenopus homolog ( XRb1) of the human retinoblastoma susceptibility gene. DNA sequence analysis shows that the XRb1 gene product is highly…”
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Fatty acid binding protein and G-protein expression in the rat kidney by Lam, Kelvin T

“…An intracellular protein capable of binding long chain fatty acids was identified and characterized in rat kidney. The protein was abundant, localized in the…”
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