Search Results - "Lam, Jenny K W"

Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA by Xu, Yingying, Liang, Wanling, Qiu, Yingshan, Cespi, Marco, Palmieri, Giovanni F, Mason, A. James, Lam, Jenny K. W

“…The major intracellular barriers associated with DNA delivery using nonviral vectors are inefficient endosomal/lysosomal escape and poor nuclear uptake…”
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Synthesis and Properties of Sucrose- and Lactose-Based Aromatic Ester Surfactants as Potential Drugs Permeability Enhancers by Verboni, Michele, Perinelli, Diego Romano, Qiu, Carol Yingshan, Tiboni, Mattia, Aluigi, Annalisa, Lucarini, Simone, Lam, Jenny K W, Duranti, Andrea

“…The delivery of therapeutics across biological membranes (e.g., mucosal barriers) by avoiding invasive routes (e.g., injection) remains a challenge in the…”
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siRNA Versus miRNA as Therapeutics for Gene Silencing by Lam, Jenny K W, Chow, Michael Y T, Zhang, Yu, Leung, Susan W S

“…Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation…”
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Pulmonary Delivery of Biological Drugs by Liang, Wanling, Pan, Harry W, Vllasaliu, Driton, Lam, Jenny K W

“…In the last decade, biological drugs have rapidly proliferated and have now become an important therapeutic modality. This is because of their high potency,…”
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Advances in Pulmonary Drug Delivery Systems and Inhalation Formulations by Lam, Jenny K. W., Zhou, Qi (Tony)

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Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways by Lam, Jenny K.W., Liang, Wanling, Lan, Yun, Chaudhuri, Poulami, Chow, Michael Y.T., Witt, Katarzyna, Kudsiova, Laila, Mason, A. James

“…Cationic amphipathic histidine rich peptides possess high plasmid DNA and siRNA delivery capabilities. To further understand the pH responsive siRNA delivery…”
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Co-Delivery of D-LAK Antimicrobial Peptide and Capreomycin as Inhaled Powder Formulation to Combat Drug-Resistant Tuberculosis by Shao, Zitong, Chow, Michael Y. T., Chow, Shing Fung, Lam, Jenny K. W.

“…Introduction The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis ( Mtb ) posed a severe challenge to tuberculosis (TB) management. The…”
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Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens by Di Blasio, Simona, Clarke, Maria, Hind, Charlotte K., Asai, Masanori, Laurence, Louis, Benvenuti, Angelica, Hassan, Mahnoor, Semenya, Dorothy, Man, DeDe Kwun-Wai, Horrocks, Victoria, Manzo, Giorgia, Van Der Lith, Sarah, Lam, Carolyn, Gentile, Eugenio, Annette, Callum, Bosse, Janine, Li, Yanwen, Panaretou, Barry, Langford, Paul R., Robertson, Brian D., Lam, Jenny K. W., Sutton, J. Mark, McArthur, Michael, Mason, A. James

“…12-Bis-THA Cl2 [12,12′-(dodecane-1,12-diyl)-bis-(9-amino-1,2,3,4-tetrahydroacridinium) chloride] is a cationic bolalipid adapted from dequalinium chloride…”
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Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery by Pan, Harry W., Seow, Han Cong, Lo, Jason C. K., Guo, Jinlin, Zhu, Lingqiao, Leung, Susan W. S., Zhang, Chenghai, Lam, Jenny K. W.

“…Objective The therapeutic options for severe asthma are limited, and the biological therapies are all parenterally administered. The purpose of this study was…”
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Delivery of RNAi Therapeutics to the Airways-From Bench to Bedside by Qiu, Yingshan, Lam, Jenny K W, Leung, Susan W S, Liang, Wanling

“…RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process. Since its discovery, tremendous efforts have been made to…”
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Optimization of PEGylated KL4 Peptide for siRNA Delivery with Improved Pulmonary Tolerance by Qiu, Yingshan, Clarke, Maria, Wan, Leon T. L, Lo, Jason C. K, Mason, A. James, Lam, Jenny K. W

“…Pulmonary delivery of small interfering RNA (siRNA) is a promising therapeutic strategy for treating various respiratory diseases but an effective carrier for…”
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From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery by Qiu, Yingshan, Chow, Michael Y. T, Liang, Wanling, Chung, Winnie W. Y, Mak, Judith C. W, Lam, Jenny K. W

“…Pulmonary delivery of small interfering RNA (siRNA) has huge potential for the treatment of a wide range of respiratory diseases. The ability of naked siRNA to…”
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Oral transmucosal drug delivery for pediatric use by Lam, Jenny K.W., Xu, Yingying, Worsley, Alan, Wong, Ian C.K.

“…The formulation of medicines for children remains a challenge. An ideal pediatric formulation must allow accurate dose administration and be in a dosage form…”
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Inhalable Protein Powder Prepared by Spray-Freeze-Drying Using Hydroxypropyl-β-Cyclodextrin as Excipient by Lo, Jason C K, Pan, Harry W, Lam, Jenny K W

“…The prospect of inhaled biologics has garnered particular interest given the benefits of the pulmonary route of administration. Pertinent considerations in…”
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Oral Delivery of Photopolymerizable Nanogels Loaded with Gemcitabine for Pancreatic Cancer Therapy: Formulation Design, and in vitro and in vivo Evaluations by Yugatama, Adi, Huang, Ya-Lin, Hsu, Ming-Jen, Lin, Jia-Pei, Chao, Fang-Ching, Lam, Jenny K W, Hsieh, Chien-Ming

“…Gemcitabine (GEM) faces challenges of poor oral bioavailability and extensive first-pass metabolism. Currently, only injectable formulations are available for…”
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Synthesis, Structure⁻Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers by Lucarini, Simone, Fagioli, Laura, Cavanagh, Robert, Liang, Wanling, Perinelli, Diego Romano, Campana, Mario, Stolnik, Snjezana, Lam, Jenny K W, Casettari, Luca, Duranti, Andrea

“…Permeability enhancers are receiving increased attention arising from their ability to increase transepithelial permeability and thus, bioavailability of…”
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Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus by Liang, Wanling, Chow, Michael Y. T, Lau, Pui Ngan, Zhou, Qi Tony, Kwok, Philip C. L, Leung, George P. H, Mason, A. James, Chan, Hak-Kim, Poon, Leo L. M, Lam, Jenny K. W

“…Pulmonary delivery of siRNA has considerable therapeutic potential for treating viral respiratory infectious diseases including influenza. By introducing siRNA…”
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Oleanolic Acid Loaded PEGylated PLA and PLGA Nanoparticles with Enhanced Cytotoxic Activity against Cancer Cells by Man, Dede K. W, Casettari, Luca, Cespi, Marco, Bonacucina, Giulia, Palmieri, Giovanni Filippo, Sze, Stephen C. W, Leung, George P. H, Lam, Jenny K. W, Kwok, Philip C. L

“…Oleanolic acid (OA) is a natural triterpenoid with anticancer properties, but its hydrophobic nature and poor aqueous solubility pose challenges in…”
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Spray-Dried Powder Formulation of Capreomycin Designed for Inhaled Tuberculosis Therapy by Shao, Zitong, Tai, Waiting, Qiu, Yingshan, Man, Rico C H, Liao, Qiuying, Chow, Michael Y T, Kwok, Philip C L, Lam, Jenny K W

“…Multi-drug-resistant tuberculosis (MDR-TB) is a huge public health problem. The treatment regimen of MDR-TB requires prolonged chemotherapy with multiple drugs…”
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Chitosan-based nanosystems and their exploited antimicrobial activity by Perinelli, Diego Romano, Fagioli, Laura, Campana, Raffaella, Lam, Jenny K.W., Baffone, Wally, Palmieri, Giovanni Filippo, Casettari, Luca, Bonacucina, Giulia

“…Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range of applications in the field of pharmaceutics, biomedical, chemical,…”
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