Search Results - "Lam, Jeff Y. L"

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease by Emin, Derya, Zhang, Yu P., Lobanova, Evgeniia, Miller, Alyssa, Li, Xuecong, Xia, Zengjie, Dakin, Helen, Sideris, Dimitrios I., Lam, Jeff Y. L., Ranasinghe, Rohan T., Kouli, Antonina, Zhao, Yanyan, De, Suman, Knowles, Tuomas P. J., Vendruscolo, Michele, Ruggeri, Francesco S., Aigbirhio, Franklin I., Williams-Gray, Caroline H., Klenerman, David

“…Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson’s disease. However, the…”
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Electrochemical Behavior of Thiocarbonylthio Chain Transfer Agents for RAFT Polymerization by Strover, Lisa T, Cantalice, Alexis, Lam, Jeff Y. L, Postma, Almar, Hutt, Oliver E, Horne, Michael D, Moad, Graeme

“…Electrochemical activation of thiocarbonylthio reversible addition–fragmentation chain transfer (RAFT) agents (S=C­(Z)­S-R) is explored as a potential method…”
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Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging by Danial, John S. H., Lam, Jeff Y. L., Wu, Yunzhao, Woolley, Matthew, Dimou, Eleni, Cheetham, Matthew R., Emin, Derya, Klenerman, David

“…Single-molecule localization microscopy (SMLM) leverages the power of modern optics to unleash ultra-precise structural nanoscopy of complex biological…”
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Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging by Danial, John S. H., Lam, Jeff Y. L., Wu, Yunzhao, Woolley, Matthew, Dimou, Eleni, Cheetham, Matthew R., Emin, Derya, Klenerman, David

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Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy by Fertan, Emre, Böken, Dorothea, Murray, Aoife, Danial, John S. H., Lam, Jeff Y. L., Wu, Yunzhao, Goh, Pollyanna A., Alić, Ivan, Cheetham, Matthew R., Lobanova, Evgeniia, Zhang, Yu P., Nižetić, Dean, Klenerman, David

“…Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer’s disease (AD) is of great importance for the rational design of…”
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Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease by Xia, Zengjie, Prescott, Emily E., Urbanek, Agnieszka, Wareing, Hollie E., King, Marianne C., Olerinyova, Anna, Dakin, Helen, Leah, Tom, Barnes, Katy A., Matuszyk, Martyna M., Dimou, Eleni, Hidari, Eric, Zhang, Yu P., Lam, Jeff Y. L., Danial, John S. H., Strickland, Michael R., Jiang, Hong, Thornton, Peter, Crowther, Damian C., Ohtonen, Sohvi, Gómez-Budia, Mireia, Bell, Simon M., Ferraiuolo, Laura, Mortiboys, Heather, Higginbottom, Adrian, Wharton, Stephen B., Holtzman, David M., Malm, Tarja, Ranasinghe, Rohan T., Klenerman, David, De, Suman

“…Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this…”
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Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson's disease by Lobanova, Evgeniia, Whiten, Daniel, Ruggeri, Francesco S, Taylor, Christopher G, Kouli, Antonina, Xia, Zengjie, Emin, Derya, Zhang, Yu P, Lam, Jeff Y L, Williams-Gray, Caroline H, Klenerman, David

“…Aggregation of α-synuclein plays a key role in the development of Parkinson's disease. Soluble aggregates are present not only within human brain but also the…”
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Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples by Böken, Dorothea, Cox, Dezerae, Burke, Melanie, Lam, Jeff Y. L., Katsinelos, Taxiarchis, Danial, John S. H., Fertan, Emre, McEwan, William A., Rowe, James B., Klenerman, David

“…Hyperphosphorylation and aggregation of the protein tau play key roles in the development of Alzheimer's disease (AD). While the molecular structure of the…”
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Super-resolution imaging unveils the self-replication of tau aggregates upon seeding by Dimou, Eleni, Katsinelos, Taxiarchis, Meisl, Georg, Tuck, Benjamin J., Keeling, Sophie, Smith, Annabel E., Hidari, Eric, Lam, Jeff Y.L., Burke, Melanie, Lövestam, Sofia, Ranasinghe, Rohan T., McEwan, William A., Klenerman, David

“…Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under pathological conditions, it becomes hyperphosphorylated and…”
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Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples by Böken, Dorothea, Cox, Dezerae, Burke, Melanie, Lam, Jeff Y. L., Katsinelos, Taxiarchis, Danial, John S. H., Fertan, Emre, McEwan, William A., Rowe, James B., Klenerman, David

“…Hyperphosphorylation and aggregation of the protein tau play key roles in the development of Alzheimer's disease (AD). While the molecular structure of the…”
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An economic, square-shaped flat-field illumination module for TIRF-based super-resolution microscopy by Lam, Jeff Y.L., Wu, Yunzhao, Dimou, Eleni, Zhang, Ziwei, Cheetham, Matthew R., Körbel, Markus, Xia, Zengjie, Klenerman, David, Danial, John S.H.

“…Super-resolution microscopy allows complex biological assemblies to be observed with remarkable resolution. However, the presence of uneven Gaussian-shaped…”
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A Novel Method for Detecting Protein Aggregates Using Plasmonic Sensing by Cheetham, Matthew R, Lam, Jeff YL, Rocchetti, Sara, Baumberg, Jeremy J, Klenerman, David

“…Background Amyloid‐beta (Aβ) protein aggregates have been implicated in the pathology of Alzheimer’s disease (AD). These aggregates are difficult to…”
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