Search Results - "Lam, E W"

Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells : impact on in vivo tumor growth by RAMASAMY, R, LAM, E. W.-F, SOEIRO, I, TISATO, V, BONNET, D, DAZZI, F

“…Mesenchymal stem cells (MSC) have received much attention in the field of hematopoietic stem cell transplantation because not only do they support…”
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Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation by Gómez-Puerto, M. C., Verhagen, L. P., Braat, A. K., Lam, E. W.-F., Coffer, P. J., Lorenowicz, M. J.

“…Bone remodeling is a continuous physiological process that requires constant generation of new osteoblasts from mesenchymal stem cells (MSCs). Differentiation…”
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Visible light positioning: moving from 2D planes to 3D spaces [Invited] by E. W. Lam, E. W. Lam, T. D. C. Little, T. D. C. Little

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Extracellular vesicles in the tumor microenvironment: Therapeutic resistance, clinical biomarkers, and targeting strategies by Han, L., Xu, J., Xu, Q., Zhang, B., Lam, E. W.‐F., Sun, Y.

“…Numerous studies have proved that cell‐nonautonomous regulation of neoplastic cells is a distinctive and essential characteristic of tumorigenesis. Two way…”
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Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers by Siu, M K Y, Wong, E S Y, Kong, D S H, Chan, H Y, Jiang, L, Wong, O G W, Lam, E W-F, Chan, K K L, Ngan, H Y S, Le, X-F, Cheung, A N

“…Ovarian cancer is the most lethal of all gynecological malignancies, and the identification of novel prognostic and therapeutic targets for ovarian cancer is…”
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SUMOylation inhibits FOXM1 activity and delays mitotic transition by Myatt, S S, Kongsema, M, Man, C W-Y, Kelly, D J, Gomes, A R, Khongkow, P, Karunarathna, U, Zona, S, Langer, J K, Dunsby, C W, Coombes, R C, French, P M, Brosens, J J, Lam, E W-F

“…The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently…”
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Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia by Peng, F, Wang, J-H, Fan, W-J, Meng, Y-T, Li, M-M, Li, T-T, Cui, B, Wang, H-F, Zhao, Y, An, F, Guo, T, Liu, X-F, Zhang, L, Lv, L, Lv, D-K, Xu, L-Z, Xie, J-J, Lin, W-X, Lam, E W-F, Xu, J, Liu, Q

“…Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate…”
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Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance by Khongkow, P, Gomes, A R, Gong, C, Man, E P S, Tsang, J W-H, Zhao, F, Monteiro, L J, Coombes, R C, Medema, R H, Khoo, U S, Lam, E W-F

“…FOXM1 has been implicated in taxane resistance, but the molecular mechanism involved remains elusive. In here, we show that FOXM1 depletion can sensitize…”
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FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer by Karadedou, C T, Gomes, A R, Chen, J, Petkovic, M, Ho, K-K, Zwolinska, A K, Feltes, A, Wong, S Y, Chan, K Y K, Cheung, Y-N, Tsang, J W H, Brosens, J J, Khoo, U-S, Lam, E W-F

“…Vascular endothelial growth factor (VEGF) has a central role in breast cancer development and progression, but the mechanisms that control its expression are…”
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FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells by Yang, N, Wang, C, Wang, Z, Zona, S, Lin, S-X, Wang, X, Yan, M, Zheng, F-M, Li, S-S, Xu, B, Bella, L, Yong, J-S, Lam, E W-F, Liu, Q

“…Substantial evidence suggests that breast cancer initiation, recurrence and drug resistance is supported by breast cancer stem cells (BCSCs). Recently, we…”
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The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment by Monteiro, L J, Khongkow, P, Kongsema, M, Morris, J R, Man, C, Weekes, D, Koo, C-Y, Gomes, A R, Pinto, P H, Varghese, V, Kenny, L M, Charles Coombes, R, Freire, R, Medema, R H, Lam, E W-F

“…FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action remain unclear. Here, we establish that γH2AX foci, indicative of DNA…”
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OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance by Karunarathna, U, Kongsema, M, Zona, S, Gong, C, Cabrera, E, Gomes, A R, Man, E P S, Khongkow, P, Tsang, J W-H, Khoo, U-S, Medema, R H, Freire, R, Lam, E W-F

“…The forkhead transcription factor FOXM1 has a key role in DNA damage response, and its deregulated overexpression is associated with genotoxic drug resistance…”
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FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis by van Boxtel, R, Gomez-Puerto, C, Mokry, M, Eijkelenboom, A, van der Vos, K E, Nieuwenhuis, E ES, Burgering, B MT, Lam, E W -F, Coffer, P J

“…Transcriptional activity of Forkhead box transcription factor class O (FOXO) proteins can result in a variety of cellular outcomes depending on cell type and…”
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The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress by Lin, A, Yao, J, Zhuang, L, Wang, D, Han, J, Lam, E W-F, Gan, B

“…Normal cells possess adaptive mechanisms to couple energy availability with cell growth (cell size increase) and survival, and imbalances are associated with…”
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Correction: FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer by Karadedou, C. T., Gomes, A. R., Chen, J., Petkovic, M., Ho, K.-K., Zwolinska, A. K., Feltes, A., Wong, S. Y., Chan, K. Y. K., Cheung, Y.-N., Tsang, J. W. H., Brosens, J. J., Khoo, U.-S., Lam, E. W.-F.

“…In the published version of this article, the images for cytoplasmic and nuclear FGF7 in MDA-MB-231 cells were duplicated and mistaken for total FGF7 in SKBR-3…”
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Many forks in the path: cycling with FoxO by Ho, K K, Myatt, S S, Lam, E W-F

“…FoxO transcription factors are an evolutionary conserved subfamily of the forkhead transcription factors, characterized by the forkhead DNA-binding domain…”
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FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance by Khongkow, P, Karunarathna, U, Khongkow, M, Gong, C, Gomes, A R, Yagüe, E, Monteiro, L J, Kongsema, M, Zona, S, Man, E P S, Tsang, J W-H, Coombes, R C, Wu, K-J, Khoo, U-S, Medema, R H, Freire, R, Lam, E W-F

“…FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains elusive. We show here that FOXM1-depletion can sensitize breast cancer…”
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FOXO transcription factors: key regulators of cell fate by Lam, E W-F, Francis, R E, Petkovic, M

“…FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FOXO proteins relies on their ability to control diverse and…”
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Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis by Kamran, M, Long, Z-J, Xu, D, Lv, S-S, Liu, B, Wang, C-L, Xu, J, Lam, E W-F, Liu, Q

“…Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number of oncogenic signaling pathways in various…”
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FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance by Millour, J, Constantinidou, D, Stavropoulou, A V, Wilson, M S C, Myatt, S S, Kwok, J M-M, Sivanandan, K, Coombes, R C, Medema, R H, Hartman, J, Lykkesfeldt, A E, Lam, E W-F

“…In this study, we investigated the regulation of FOXM1 expression by estrogen receptor α (ERα) and its role in hormonal therapy and endocrine resistance. FOXM1…”
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