Search Results - "Lam, Dieter"

Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates by Wang, Allen, Yue, Feng, Li, Yan, Xie, Ruiyu, Harper, Thomas, Patel, Nisha A., Muth, Kayla, Palmer, Jeffrey, Qiu, Yunjiang, Wang, Jinzhao, Lam, Dieter K., Raum, Jeffrey C., Stoffers, Doris A., Ren, Bing, Sander, Maike

“…Embryonic development relies on the capacity of progenitor cells to appropriately respond to inductive cues, a cellular property known as developmental…”
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Improved cytosine base editors generated from TadA variants by Lam, Dieter K., Feliciano, Patricia R., Arif, Amena, Bohnuud, Tanggis, Fernandez, Thomas P., Gehrke, Jason M., Grayson, Phil, Lee, Kin D., Ortega, Manuel A., Sawyer, Courtney, Schwaegerle, Noah D., Peraro, Leila, Young, Lauren, Lee, Seung-Joo, Ciaramella, Giuseppe, Gaudelli, Nicole M.

“…Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally…”
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Directed evolution of adenine base editors with increased activity and therapeutic application by Gaudelli, Nicole M., Lam, Dieter K., Rees, Holly A., Solá-Esteves, Noris M., Barrera, Luis A., Born, David A., Edwards, Aaron, Gehrke, Jason M., Lee, Seung-Joo, Liquori, Alexander J., Murray, Ryan, Packer, Michael S., Rinaldi, Conrad, Slaymaker, Ian M., Yen, Jonathan, Young, Lauren E., Ciaramella, Giuseppe

“…The foundational adenine base editors (for example, ABE7.10) enable programmable A•T to G•C point mutations but editing efficiencies can be low at challenging…”
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Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors by Geusz, Ryan J., Wang, Allen, Lam, Dieter K., Vinckier, Nicholas K., Alysandratos, Konstantinos-Dionysios, Roberts, David A., Wang, Jinzhao, Kefalopoulou, Samy, Ramirez, Araceli, Qiu, Yunjiang, Chiou, Joshua, Gaulton, Kyle J., Ren, Bing, Kotton, Darrell N., Sander, Maike

“…FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas…”
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Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease by Chu, S. Haihua, Budak, Elizabeth, Mondal, Nandini, Zhang, Kathy, Harmon, Alexander, Wong, Jeffrey, Lam, Dieter, Lucini, Corrina, Coisman, Brent, Qiao, Kangjian, Bai, Tao, Decker, Jeremy, Gantzer, Bob, Lee, Kindo, Sen, Maya, Bohnuud, Tanggis, Barrera, Luis, Cafferty, Brian, Lee, Seung-Joo, Kopesky, Paul, Gaudelli, Nicole M., McDonagh, Charlotte F, Ciaramella, Giuseppe, Hartigan, Adam J.

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Role of Pioneer Transcription Factors FOXA1 and FOXA2 during Pancreatic Specification of Human Embryonic Stem Cells by Lam, Dieter Ka Yeung

“…During pancreas development, undifferentiated cells must undergo stepwise progression toward particular cell fates. The emergence of the distinct cell types of…”
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