Search Results - "Lam, Colin S.C."

Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma by Chow, Ariel K M, Ng, Lui, Sing Li, Hung, Cheng, Chi Wai, Lam, Colin S C, Yau, Thomas C C, Cheng, Paul N M, Fan, Sheung Tat, Poon, Ronnie T P, Pang, Roberta W C

“…Hepatocellular carcinoma (HCC) is considered as auxotrophic for arginine and BCT-100, a new recombinant human arginase, has been synthesized for arginine…”
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Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1 by Zhang, Wenjing, Wang, Jide, Zou, Bing, Sardet, Claude, Li, Jianming, Lam, Colin S.C, Ng, Lui, Pang, Roberta, Hung, Ivan F.N, Tan, Victoria P.Y, Jiang, Bo, Wong, Benjamin C.Y

“…Abstract E-cadherin is a hallmark of epithelial–mesenchymal transition (EMT), which plays a crucial role in cancer metastasis. We previously demonstrated that…”
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XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification by Zou, Bing, Chim, Chor S., Pang, Roberta, Zeng, Hui, Dai, Yun, Zhang, Rongxin, Lam, Colin S.C., Tan, Victoria P.Y., Hung, Ivan F.N., Lan, Hui Y., Wong, Benjamin C.Y.

“…The role of X chromosome‐linked inhibitor of apoptosis protein (XIAP)‐associated factor 1 (XAF1) in mediating apoptosis has been reported but the underlying…”
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Promoter hypermethylation and histone hypoacetylation contribute to pancreatic-duodenal homeobox 1 silencing in gastric cancer by Ma, Juan, Wang, Ji-De, Zhang, Wen-Jing, Zou, Bing, Chen, Wen-Ji, Lam, Colin S.C., Chen, Min-Hu, Pang, Roberta, Tan, V.P.Y., Hung, I.F., Lan, Hui-Yao, Wang, Qi-Yi, Wong, Benjamin C.Y.

“…Background and Aims: The expression of pancreatic-duodenal homeobox 1 (PDX1) in gastric cancer is aberrantly reduced. The aim of this study was to elucidate…”
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Adenovirus-mediated down-regulation of X-linked inhibitor of apoptosis protein inhibits colon cancer by Dai, Yun, Qiao, Liang, Chan, Kwok Wah, Yang, Mo, Ye, Jieyu, Zhang, Rongxin, Ma, Juan, Zou, Bing, Lam, Colin S C, Wang, Jide, Pang, Roberta, Tan, Victoria P Y, Lan, H Y, Wong, Benjamin C Y

“…Our previous studies and those of others have indicated that X-linked inhibitor of apoptosis protein ( XIAP ) holds promise as a target gene in colon cancer…”
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A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer by Pang, Roberta, Law, Wai Lun, Chu, Andrew C.Y., Poon, Jensen T., Lam, Colin S.C., Chow, Ariel K.M., Ng, Lui, Cheung, Leonard W.H., Lan, Xiao R., Lan, Hui Y., Tan, Victoria P.Y., Yau, Thomas C., Poon, Ronnie T., Wong, Benjamin C.Y.

“…Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However,…”
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Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer by Zhang, Wenjing, Jiang, Bo, Guo, Zheng, Sardet, Claude, Zou, Bing, Lam, Colin S.C., Li, Jianming, He, Mingliang, Lan, Hui-Yao, Pang, Roberta, Hung, I.F.N., Tan, V.P.Y., Wang, Jide, Wong, Benjamin C.Y.

“…Background and Aims: Cancer invasion and metastasis may associate with the phenotype transition called epithelial-mesenchymal transition (EMT). We aim to…”
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Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently by Fu, Hongjun, Dou, Juan, Li, Wenming, Cui, Wei, Mak, Shinghung, Hu, Qiansheng, Luo, Jialie, Lam, Colin S.C., Pang, Yuanping, Youdim, Moussa B.H., Han, Yifan

“…We have recently demonstrated that bis(7)-Cognitin, a promising multifunctional anti-Alzheimer 's dimer, can remarkably reduce the generation of amyloid β…”
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Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma by Chow, Ariel K M, Cheng, Nathan S M, Lam, Colin S C, Ng, Lui, Wong, Sunny K M, Wan, Timothy M H, Man, Johnny H W, Cheung, Alvin H K, Yau, Thomas C C, Poon, Jensen T C, Law, Wai-Lun, Pang, Roberta W C

“…In colorectal carcinoma (CRC), activation of the Raf/MEK/ERK signaling pathway is commonly observed. In addition, the commonly used 5FU-based chemotherapy in…”
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Trend of colorectal cancer in Hong Kong: 1983-2006 by Yee, Yuk Kei, Gu, Qing, Hung, Ivan, Tan, Victoria PY, Chan, Pierre, Hsu, Axel, Pang, Roberta, Lam, Colin SC, Wong, Benjamin CY

“…Background and Aim:  The incidence of colorectal cancer (CC) is increasing in many Asian countries, but decreasing in western countries. The present study…”
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Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase by Li, Wenming, Xue, Jian, Niu, Chunying, Fu, Hongjun, Lam, Colin S C, Luo, Jialie, Chan, Hugh H N, Xue, Huaiguo, Kan, Kelvin K W, Lee, Nelson T K, Li, Chaoying, Pang, Yuanping, Li, Mingtao, Tsim, Karl W K, Jiang, Hualiang, Chen, Kaixian, Li, Xiaoyuan, Han, Yifan

“…The excessive activation of the N-methyl-D-aspartate receptor (NMDAR)/nitric oxide (NO) pathway has been proposed to be involved in the neuropathology of…”
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Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms by Fu, Hongjun, Dou, Juan, Li, Wenming, Luo, Jialie, Li, Kenny C., Lam, Colin S.C., Lee, Nelson T.K., Li, Mingtao, Han, Yifan

“…Neuronal loss via apoptosis caused by various stimuli may be the fundamental mechanism underlying chronic and acute neurodegenerative diseases. A drug…”
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XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a Half LIM protein 2 by Zhang, Wenjing, Yang, Yi, Jiang, Bo, Peng, Junzhong, Tu, Shuiping, Sardet, Claude, Zhang, Yusheng, Pang, Roberta, Hung, Ivan F, Tan, V. P. Y., Lam, Colin SC, Wang, Jide, Wong, Benjamin C.Y.

“…XIAP‐associated factor 1(XAF1) is a tumor suppressor with its functional mechanisms not fully understood. The zinc‐finger cluster located at the N‐terminus is…”
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