Search Results - "Lam, Carol J."

Tamoxifen suppresses pancreatic β-cell proliferation in mice by Ahn, Surl-Hee, Granger, Anne, Rankin, Matthew M, Lam, Carol J, Cox, Aaron R, Kushner, Jake A

“…Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene…”
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Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3 by Carlson, Scott M, Chouinard, Candace R, Labadorf, Adam, Lam, Carol J, Schmelzle, Katrin, Fraenkel, Ernest, White, Forest M

“…The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase 2 (ERK2) is ubiquitously expressed in mammalian tissues and is involved in a…”
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Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy by Cox, Aaron R, Barrandon, Ornella, Cai, Erica P, Rios, Jacqueline S, Chavez, Julia, Bonnyman, Claire W, Lam, Carol J, Yi, Peng, Melton, Douglas A, Kushner, Jake A

“…The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced…”
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Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes by Shields, Emily J, Lam, Carol J, Cox, Aaron R, Rankin, Matthew M, Van Winkle, Thomas J, Hess, Rebecka S, Kushner, Jake A

“…The pathophysiology of canine diabetes remains poorly understood, in part due to enigmatic clinical features and the lack of detailed histopathology studies…”
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Low-Level Insulin Content Within Abundant Non-β Islet Endocrine Cells in Long-standing Type 1 Diabetes by Lam, Carol J, Chatterjee, Anirudha, Shen, Emily, Cox, Aaron R, Kushner, Jake A

“…Although most patients with type 1 diabetes (T1D) continue to produce small amounts of insulin decades after disease onset, very few β-cells persist within…”
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β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis by Lam, Carol J, Jacobson, Daniel R, Rankin, Matthew M, Cox, Aaron R, Kushner, Jake A

“…Abstract Context The cellular basis of persistent β-cell function in type 1 diabetes (T1D) remains enigmatic. No extensive quantitative β-cell studies of T1D…”
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Highly Proliferative α-Cell-Related Islet Endocrine Cells in Human Pancreata by Lam, Carol J, Cox, Aaron R, Jacobson, Daniel R, Rankin, Matthew M, Kushner, Jake A

“…The proliferative response of non-β islet endocrine cells in response to type 1 diabetes (T1D) remains undefined. We quantified islet endocrine cell…”
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Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice by Cox, Aaron R., Lam, Carol J., Bonnyman, Claire W., Chavez, Julia, Rios, Jacqueline S., Kushner, Jake A.

“…Aims/hypothesis The identification of novel targets that stimulate endogenous regeneration of beta cells would represent a significant advance in the treatment…”
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Glucagon Receptor Antagonist-Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age by Lam, Carol J, Rankin, Matthew M, King, Kourtney B, Wang, Melinda C, Shook, Brian C, Kushner, Jake A

“…Glucagon-containing α-cells potently regulate glucose homeostasis, but the developmental biology of α-cells in adults remains poorly understood. Although…”
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Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage by Cox, Aaron R., Lam, Carol J., Rankin, Matthew M., King, Kourtney A., Chen, Pan, Martinez, Ramon, Li, Changhong, Kushner, Jake A.

“…Aims/hypothesis Understanding the developmental biology of beta cell regeneration is critical for developing new diabetes therapies. Obesity is a potent but…”
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Incretin Therapies Do Not Expand β-Cell Mass or Alter Pancreatic Histology in Young Male Mice by Cox, Aaron R., Lam, Carol J., Rankin, Matthew M., Rios, Jacqueline S., Chavez, Julia, Bonnyman, Claire W., King, Kourtney B., Wells, Roger A., Anthony, Deepti, Tu, Justin X., Kim, Jenny J., Li, Changhong, Kushner, Jake A.

“…The impact of incretins upon pancreatic β-cell expansion remains extremely controversial. Multiple studies indicate that incretin-based therapies can increase…”
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Tamoxifen suppresses pancreatic [beta]-cell proliferation in mice by Ahn, Surl-Hee, Granger, Anne, Rankin, Matthew M, Lam, Carol J, Cox, Aaron R, Kushner, Jake A

“…Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene…”
Get full text

Highly Proliferative a-Cell–Related Islet Endocrine Cells in Human Pancreata by Lam, Carol J, Cox, Aaron R, Jacobson, Daniel R, Rankin, Matthew M, Kushner, Jake A

“…The proliferative response of non-β islet endocrine cells in response to type 1 diabetes (T1D) remains undefined. We quantified islet endocrine cell…”
Get full text

[beta] Cells Persist in T1D Pancreata Without Evidence of Ongoing [beta]-Cell Turnover or Neogenesis by Lam, Carol J, Jacobson, Daniel R, Rankin, Matthew M, Cox, Aaron R, Kushner, Jake A

“…Abstract The cellular basis of persistent β -cell function in type 1 diabetes (T1D) remains enigmatic. No extensive quantitative β -cell studies of T1D…”
Get full text

Resolving Discrepant Findings on ANGPTL8 in [beta]-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy by Cox, Aaron R, Barrandon, Ornella, Cai, Erica P, Rios, Jacqueline S, Chavez, Julia, Bonnyman, Claire W, Lam, Carol J, Yi, Peng, Melton, Douglas A, Kushner, Jake A

“…The [beta]-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice…”
Get full text

Incretin Therapies Do Not Expand [beta]-Cell Mass or Alter Pancreatic Histology in Young Male Mice by Cox, Aaron R, Lam, Carol J, Rankin, Matthew M, Rios, Jacqueline S, Chavez, Julia, Bonnyman, Claire W, King, Kourtney B, Wells, Roger A, Anthony, Deepti, Tu, Justin X, Kim, Jenny J, Li, Changhong, Kushner, Jake A

“…Abstract The impact of incretins upon pancreatic β -cell expansion remains extremely controversial. Multiple studies indicate that incretin-based therapies can…”
Get full text