Search Results - "Lam, Betty"

Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia by Reichard, Holly A, Schiffer, Hans H, Monenschein, Holger, Atienza, Josephine M, Corbett, Gerard, Skaggs, Alton W, Collia, Deanna R, Ray, William J, Serrats, Jordi, Bliesath, Joshua, Kaushal, Nidhi, Lam, Betty P, Amador-Arjona, Alejandro, Rahbaek, Lisa, McConn, Donavon J, Mulligan, Victoria J, Brice, Nicola, Gaskin, Philip L. R, Cilia, Jackie, Hitchcock, Stephen

“…The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a small brain nucleus that has been linked to depression, schizophrenia…”
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Clinical significance of unexplained persistent sinus tachycardia in women with structurally normal heart during the peripartum period by Varrias, Dimitrios, Sharma, Nikhil, Hentz, Roland, Ma, Rosaline, Gurciullo, Dillon, Kleiman, Jeremy, Kossack, Andrew, Wolf, Eliot, Lam, Betty, Bimal, Tia, Ansari, Umair, Coleman, Kristie M., Mountantonakis, Stavros E.

“…Abstract Background Persistent sinus tachycardia (ST) is frequently encountered during pregnancy and peripartum period and its etiology often remains elusive…”
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Transition probabilities of diabetic retinopathy and death in an Asian population with diabetes by Seshasai, Sudarshan, He, Feng, Lam, Betty, Hamzah, Haslina, Cheng, Ching-Yu, Li, Jialiang, Wong, Tien Yin, Tan, Gavin Siew Wei, Sabanayagam, Charumathi

“…To evaluate the dynamic transitions in diabetic retinopathy (DR) severity over time and associated risk factors in an Asian population with diabetes…”
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Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors by Kiryanov, Andre, Natala, Srinivasa, Jones, Benjamin, McBride, Christopher, Feher, Victoria, Lam, Betty, Liu, Yan, Honda, Kouhei, Uchiyama, Noriko, Kawamoto, Tomohiro, Hikichi, Yuichi, Zhang, Lilly, Hosfield, David, Skene, Robert, Zou, Hua, Stafford, Jeffrey, Cao, Xiaodong, Ichikawa, Takashi

“…[Display omitted] Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine PLK1 inhibitors. Rational…”
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Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1) by Nie, Zhe, Feher, Victoria, Natala, Srinivasa, McBride, Christopher, Kiryanov, Andre, Jones, Benjamin, Lam, Betty, Liu, Yan, Kaldor, Stephen, Stafford, Jeffrey, Hikami, Kouki, Uchiyama, Noriko, Kawamoto, Tomohiro, Hikichi, Yuichi, Matsumoto, Shin-ichi, Amano, Nobuyuki, Zhang, Lilly, Hosfield, David, Skene, Robert, Zou, Hua, Cao, Xiaodong, Ichikawa, Takashi

“…Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the…”
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Leveraging electronic health record query to streamline adverse event reporting and protocol compliance by Coleman, Kristie M., Lam, Betty, George, Deepika, Brennan, Christina, Mountantonakis, Stavros E.

“…Electronic medical records are increasingly being leveraged to improve the efficiency and effectiveness of clinical trials. Reporting safety data and adhering…”
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase by Baltgalvis, Kristen A., Lamb, Kelsey N., Symons, Kent T., Wu, Chu-Chiao, Hoffman, Melissa A., Snead, Aaron N., Song, Xiaodan, Glaza, Thomas, Kikuchi, Shota, Green, Jason C., Rogness, Donald C., Lam, Betty, Rodriguez-Aguirre, Maria E., Woody, David R., Eissler, Christie L., Rodiles, Socorro, Negron, Seth M., Bernard, Steffen M., Tran, Eileen, Pollock, Jonathan, Tabatabaei, Ali, Contreras, Victor, Williams, Heather N., Pastuszka, Martha K., Sigler, John J., Pettazzoni, Piergiorgio, Rudolph, Markus G., Classen, Moritz, Brugger, Doris, Claiborne, Christopher, Plancher, Jean-Marc, Cuartas, Isabel, Seoane, Joan, Burgess, Laurence E., Abraham, Robert T., Weinstein, David S., Simon, Gabriel M., Patricelli, Matthew P., Kinsella, Todd M.

“…WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious…”
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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK) by Lam, Betty, Arikawa, Yasuyoshi, Cramlett, Joshua, Dong, Qing, de Jong, Ron, Feher, Victoria, Grimshaw, Charles E., Farrell, Pamela J., Hoffman, Isaac D., Jennings, Andy, Jones, Benjamin, Matuszkiewicz, Jennifer, Miura, Joanne, Miyake, Hiroshi, Natala, Srinivasa Reddy, Shi, Lihong, Takahashi, Masashi, Taylor, Ewan, Wyrick, Corey, Yano, Jason, Zalevsky, Jonathan, Nie, Zhe

“…[Display omitted] Spleen Tyrosine Kinase (SYK) is a non-receptor cytoplasmic tyrosine kinase that is primarily expressed in hematopoietic cells. SYK is a key…”
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Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase by Baltgalvis, Kristen A., Lamb, Kelsey N., Symons, Kent T., Wu, Chu-Chiao, Hoffman, Melissa A., Snead, Aaron N., Song, Xiaodan, Glaza, Thomas, Kikuchi, Shota, Green, Jason C., Rogness, Donald C., Lam, Betty, Rodriguez-Aguirre, Maria E., Woody, David R., Eissler, Christie L., Rodiles, Socorro, Negron, Seth M., Bernard, Steffen M., Tran, Eileen, Pollock, Jonathan, Tabatabaei, Ali, Contreras, Victor, Williams, Heather N., Pastuszka, Martha K., Sigler, John J., Pettazzoni, Piergiorgio, Rudolph, Markus G., Classen, Moritz, Brugger, Doris, Claiborne, Christopher, Plancher, Jean-Marc, Cuartas, Isabel, Seoane, Joan, Burgess, Laurence E., Abraham, Robert T., Weinstein, David S., Simon, Gabriel M., Patricelli, Matthew P., Kinsella, Todd M.

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Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase by Kikuchi, Shota, Pettazzoni, Piergiorgio, Baltgalvis, Kristen A., Lamb, Kelsey N., Symons, Kent T., Wu, Chu-Chiao, Hoffman, Melissa A., Snead, Aaron N., Song, Xiaodan, Glaza, Thomas, Green, Jason C., Rogness, Donald C., Lam, Betty, Rodriguez-Aguirre, Maria E., Woody, David R., Eissler, Christie L., Rodiles, Socorro, Negron, Seth M., Bernard, Steffen M., Tran, Eileen, Pollock, Jonathan, Tabatabaei, Ali, Contreras, Victor, Williams, Heather N., Pastuszka, Martha K., Sigler, John J., Rudolph, Markus G., Classen, Moritz, Brugger, Doris, Claiborne, Christopher, Plancher, Jean-Marc, Cuartas, Isabel, Seoane, Joan, Burgess, Laurence E., Abraham, Robert T., Weinstein, David S., Simon, Gabriel M., Patricelli, Matthew P., Kinsella, Todd M.

“…Abstract WRN helicase is a promising target for treating cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious…”
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Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors by Lam, Betty, Zhang, Zhiyuan, Stafford, Jeffery A., Skene, Robert J., Shi, Lihong, Gwaltney, Stephen L.

“…Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment…”
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The challenge of Roger Sessions' First Piano Sonata: Understanding how its evolution, its language, and its notation can suggest a performing style by Woo, Betty King-Lam

“…Roger Sessions believed that a true musical experience can occur only if there is an understanding between the composer and the performer. From the performer's…”
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