Search Results - "Lam, Alice"

What motivates academic scientists to engage in research commercialization: ‘Gold’, ‘ribbon’ or ‘puzzle’? by Lam, Alice

“…► The study applies a social-psychological perspective to examine scientists’ personal motivations for commercial engagement. ► Scientists engage in commercial…”
Get full text

Linking Late-Onset Epilepsy With Alzheimer Disease: Insights From Plasma Amyloid Measurements by Lam, Alice D

Get full text

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease by Lam, Alice D, Deck, Gina, Goldman, Alica, Eskandar, Emad N, Noebels, Jeffrey, Cole, Andrew J

“…Using intracranial electrode recordings in two individuals with Alzheimer's disease, Lam et al . discover hippocampal seizure activity that could not be…”
Get full text

Cell-intrinsic mechanical regulation of plasma membrane accumulation at the cytokinetic furrow by Alonso-Matilla, Roberto, Lam, Alice R, Miettinen, Teemu P

“…Cytokinesis is the process where the mother cell's cytoplasm separates into daughter cells. This is driven by an actomyosin contractile ring that produces…”
Get full text

Association of epileptiform abnormalities and seizures in Alzheimer disease by Lam, Alice D., Sarkis, Rani A., Pellerin, Kyle R., Jing, Jin, Dworetzky, Barbara A., Hoch, Daniel B., Jacobs, Claire S., Lee, Jong Woo, Weisholtz, Daniel S., Zepeda, Rodrigo, Westover, M. Brandon, Cole, Andrew J., Cash, Sydney S.

“…OBJECTIVETo examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers…”
Get full text

Towards a coherent view of network hyperexcitability in Alzheimer's disease by Lam, Alice D, Shafi, Mouhsin M

“…This scientific commentary refers to ‘Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer’s disease’ by…”
Get full text

Tacit Knowledge, Organizational Learning and Societal Institutions: An Integrated Framework by Lam, Alice

“…The importance of tacit knowledge in organizational learning and innovation has become the focus of considerable attention in the recent literature. Our…”
Get full text

Epilepsy and sleep characteristics are associated with diminished 24-h memory retention in older adults with epilepsy by Sarkis, Rani A, Lam, Alice D, Pavlova, Milena, Locascio, Joseph J, Putta, Swapna, Puri, Nirajan, Pham, Jonathan, Yih, Alison, Marshall, Gad A, Stickgold, Robert

“…Individuals with epilepsy often have memory difficulties, and older adults with epilepsy are especially vulnerable, due to the additive effect of aging. The…”
Get full text

Detection of mesial temporal lobe epileptiform discharges on intracranial electrodes using deep learning by Abou Jaoude, Maurice, Jing, Jin, Sun, Haoqi, Jacobs, Claire S., Pellerin, Kyle R., Westover, M. Brandon, Cash, Sydney S., Lam, Alice D.

“…•We developed a deep learning algorithm to detect mesial temporal lobe epileptiform discharges on intracranial EEG.•Convolutional neural networks with simple…”
Get full text

Practicalities (and real-life experiences) of dementia in adults with Down syndrome by Harisinghani, Ayesha, Cottrell, Clorinda, Donelan, Karen, Lam, Alice D, Pulsifer, Margaret, Santoro, Stephanie L

“…Adults with down syndrome (DS) have a lifetime dementia risk in excess of 95%, with a median age of onset of 55 years, due to trisomy 21. Co-occurring…”
Get full text

Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation by Jing, Jin, Sun, Haoqi, Kim, Jennifer A, Herlopian, Aline, Karakis, Ioannis, Ng, Marcus, Halford, Jonathan J, Maus, Douglas, Chan, Fonda, Dolatshahi, Marjan, Muniz, Carlos, Chu, Catherine, Sacca, Valeria, Pathmanathan, Jay, Ge, Wendong, Dauwels, Justin, Lam, Alice, Cole, Andrew J, Cash, Sydney S, Westover, M Brandon

“…Interictal epileptiform discharges (IEDs) in electroencephalograms (EEGs) are a biomarker of epilepsy, seizure risk, and clinical decline. However, there is a…”
Get more information

Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease by Lam, Alice D., Noebels, Jeffrey

“…Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline…”
Get full text

Expert-level automated sleep staging of long-term scalp electroencephalography recordings using deep learning by Abou Jaoude, Maurice, Sun, Haoqi, Pellerin, Kyle R, Pavlova, Milena, Sarkis, Rani A, Cash, Sydney S, Westover, M Brandon, Lam, Alice D

“…Abstract Study Objectives Develop a high-performing, automated sleep scoring algorithm that can be applied to long-term scalp electroencephalography (EEG)…”
Get full text

Altered Sleep Microarchitecture and Cognitive Impairment in Patients With Temporal Lobe Epilepsy by Bender, Alex C, Jaleel, Afareen, Pellerin, Kyle R, Moguilner, Sebastian, Sarkis, Rani A, Cash, Sydney S, Lam, Alice D

“…To investigate the spatiotemporal characteristics of sleep waveforms in temporal lobe epilepsy (TLE) and examine their association with cognition. In this…”
Get full text

Decoding information about cognitive health from the brainwaves of sleep by Adra, Noor, Dümmer, Lisa W., Paixao, Luis, Tesh, Ryan A., Sun, Haoqi, Ganglberger, Wolfgang, Westmeijer, Mike, Da Silva Cardoso, Madalena, Kumar, Anagha, Ye, Elissa, Henry, Jonathan, Cash, Sydney S., Kitchener, Erin, Leveroni, Catherine L., Au, Rhoda, Rosand, Jonathan, Salinas, Joel, Lam, Alice D., Thomas, Robert J., Westover, M. Brandon

“…Sleep electroencephalogram (EEG) signals likely encode brain health information that may identify individuals at high risk for age-related brain diseases…”
Get full text

Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study by Johnson, Emily L., Krauss, Gregory L., Kucharska-Newton, Anna, Lam, Alice D., Sarkis, Rani, Gottesman, Rebecca F.

“…To determine the risk of mortality and causes of death in persons with late-onset epilepsy (LOE) compared to those without epilepsy in a community-based…”
Get full text

EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer's Disease by Azami, Hamed, Moguilner, Sebastian, Penagos, Hector, Sarkis, Rani A, Arnold, Steven E, Gomperts, Stephen N, Lam, Alice D

“…Alzheimer's disease (AD) is associated with EEG changes across the sleep-wake cycle. As the brain is a non-linear system, non-linear EEG features across…”
Get more information

Noninvasive Detection of Hippocampal Epileptiform Activity on Scalp Electroencephalogram by Abou Jaoude, Maurice, Jacobs, Claire S, Sarkis, Rani A, Jing, Jin, Pellerin, Kyle R, Cole, Andrew J, Cash, Sydney S, Westover, M Brandon, Lam, Alice D

“…The hippocampus is a highly epileptogenic brain region, yet over 90% of hippocampal epileptiform activity (HEA) cannot be identified on scalp…”
Get more information

Dementia detection from brain activity during sleep by Ye, Elissa M, Sun, Haoqi, Krishnamurthy, Parimala V, Adra, Noor, Ganglberger, Wolfgang, Thomas, Robert J, Lam, Alice D, Westover, M Brandon

“…Abstract Study Objectives Dementia is a growing cause of disability and loss of independence in the elderly, yet remains largely underdiagnosed. Early…”
Get full text

Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures by Lam, Alice D, Thibault, Emma G, Mayblyum, Danielle V, Hsieh, Stephanie, Pellerin, Kyle R, Sternberg, Eliezer J, Viswanathan, Anand, Buss, Stephanie, Sarkis, Rani A, Jacobs, Heidi I L, Johnson, Keith A, Sperling, Reisa A

“…Alzheimer disease (AD) is associated with a 2 to 3-fold increased risk of developing late-onset focal epilepsy, yet it remains unclear how development of focal…”
Get full text