Search Results - "Lalli, Matthew A."

Rapid and Extraction-Free Detection of SARS-CoV-2 from Saliva by Colorimetric Reverse-Transcription Loop-Mediated Isothermal Amplification by Lalli, Matthew A, Langmade, Joshua S, Chen, Xuhua, Fronick, Catrina C, Sawyer, Christopher S, Burcea, Lauren C, Wilkinson, Michael N, Fulton, Robert S, Heinz, Michael, Buchser, William J, Head, Richard D, Mitra, Robi D, Milbrandt, Jeffrey

“…Abstract Background Rapid, reliable, and widespread testing is required to curtail the ongoing COVID-19 pandemic. Current gold-standard nucleic acid tests are…”
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Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate by Jang, Jiwon, Wang, Yidi, Lalli, Matthew A., Guzman, Elmer, Godshalk, Sirie E., Zhou, Hongjun, Kosik, Kenneth S.

“…Under defined differentiation conditions, human embryonic stem cells (hESCs) can be directed toward a mesendoderm (ME) or neuroectoderm (NE) fate, the first…”
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High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation by Lalli, Matthew A, Avey, Denis, Dougherty, Joseph D, Milbrandt, Jeffrey, Mitra, Robi D

“…The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel…”
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Nrf2, a Regulator of the Proteasome, Controls Self‐Renewal and Pluripotency in Human Embryonic Stem Cells by Jang, Jiwon, Wang, Yidi, Kim, Hyung‐Seok, Lalli, Matthew A., Kosik, Kenneth S.

“…Nuclear factor, erythroid 2‐like 2 (Nrf2) is a master transcription factor for cellular defense against endogenous and exogenous stresses by regulating…”
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Synaptic dysregulation in a human iPS cell model of mental disorders by Wen, Zhexing, Nguyen, Ha Nam, Guo, Ziyuan, Lalli, Matthew A., Wang, Xinyuan, Su, Yijing, Kim, Nam-Shik, Yoon, Ki-Jun, Shin, Jaehoon, Zhang, Ce, Makri, Georgia, Nauen, David, Yu, Huimei, Guzman, Elmer, Chiang, Cheng-Hsuan, Yoritomo, Nadine, Kaibuchi, Kozo, Zou, Jizhong, Christian, Kimberly M., Cheng, Linzhao, Ross, Christopher A., Margolis, Russell L., Chen, Gong, Kosik, Kenneth S., Song, Hongjun, Ming, Guo-li

“…Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology…”
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Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate by Srikanth, Priya, Han, Karam, Callahan, Dana G., Makovkina, Eugenia, Muratore, Christina R., Lalli, Matthew A., Zhou, Honglin, Boyd, Justin D., Kosik, Kenneth S., Selkoe, Dennis J., Young-Pearse, Tracy L.

“…Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is…”
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Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways by Lalli, Matthew A, Jang, Jiwon, Park, Joo-Hye C, Wang, Yidi, Guzman, Elmer, Zhou, Hongjun, Audouard, Morgane, Bridges, Daniel, Tovar, Kenneth R, Papuc, Sorina M, Tutulan-Cunita, Andreea C, Huang, Yadong, Budisteanu, Magdalena, Arghir, Aurora, Kosik, Kenneth S

“…Williams syndrome (WS) is a neurodevelopmental disorder caused by a genomic deletion of ∼28 genes that results in a cognitive and behavioral profile marked by…”
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MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes by Bettcher, Brianne M, Fitch, Ryan, Wynn, Matthew J, Lalli, Matthew A, Elofson, Jonathan, Jastrzab, Laura, Mitic, Laura, Miller, Zachary A, Rabinovici, Gil D, Miller, Bruce L, Kao, Aimee W, Kosik, Kenneth S, Kramer, Joel H

“…Abstract Introduction MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether…”
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ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification by Yang, Seungbok, Golkaram, Mahdi, Oh, Seyoun, Oh, Yujeong, Cho, Yoonjae, Yoe, Jeehyun, Ju, Sungeun, Lalli, Matthew A., Park, Seung-Yeol, Lee, Yoontae, Jang, Jiwon

“…Dynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferation. Although regulatory mechanisms…”
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Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells by Moudgil, Arnav, Wilkinson, Michael N., Chen, Xuhua, He, June, Cammack, Alexander J., Vasek, Michael J., Lagunas, Tomás, Qi, Zongtai, Lalli, Matthew A., Guo, Chuner, Morris, Samantha A., Dougherty, Joseph D., Mitra, Robi D.

“…Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell RNA sequencing (scRNA-seq) deconvolves cell types from gene…”
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Soluble syntaxin 3 functions as a transcriptional regulator by Giovannone, Adrian J., Winterstein, Christine, Bhattaram, Pallavi, Reales, Elena, Low, Seng Hui, Baggs, Julie E., Xu, Mimi, Lalli, Matthew A., Hogenesch, John B., Weimbs, Thomas

“…Syntaxins are a conserved family of SNARE proteins and contain C-terminal transmembrane anchors required for their membrane fusion activity. Here we show that…”
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Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease by Lalli, Matthew A, Cox, Hannah C, Arcila, Mary L, Cadavid, Liliana, Moreno, Sonia, Garcia, Gloria, Madrigal, Lucia, Reiman, Eric M, Arcos-Burgos, Mauricio, Bedoya, Gabriel, Brunkow, Mary E, Glusman, Gustavo, Roach, Jared C, Hood, Leroy, Kosik, Kenneth S, Lopera, Francisco

“…Abstract Background A mutation in presenilin 1 (E280A) causes early-onset Alzheimer's disease. Understanding the origin of this mutation will inform medical…”
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Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers by Lalli, Matthew A., Garcia, Gloria, Madrigal, Lucia, Arcos-Burgos, Mauricio, Arcila, Mary Luz, Kosik, Kenneth S., Lopera, Francisco

“…Identifying genes that modify the age at onset (AAO) of Alzheimer disease and targeting them pharmacologically represent a potential treatment strategy. In…”
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