Search Results - "Lalevée, Nathalie"
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Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study
Published in Critical care medicine (01-07-2018)“…OBJECTIVES:To investigate any gender effect of the beta-1 adrenergic blocker, landiolol, on cardiac performance and energy metabolism in septic rats, and to…”
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Management and Research in Cancer Treatment-Related Cardiovascular Toxicity: Challenges and Perspectives
Published in International journal of cardiology (01-12-2016)“…Abstract Cardiovascular toxicity is a potentially serious complication that can result from the use of various cancer therapies and can impact the short- and…”
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Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart
Published in PLoS genetics (01-09-2010)“…Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development…”
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Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis
Published in Intensive care medicine experimental (19-08-2019)“…Objectives The aims of this study are to better understand phenotypic differences between male and female rats during sepsis, to characterise the contribution…”
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Correction: Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy
Published in PLoS genetics (15-08-2018)“…[This corrects the article DOI: 10.1371/journal.pgen.1007502.]…”
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Cardiac MRI Features and Prognostic Value in Immune Checkpoint Inhibitor-induced Myocarditis
Published in Radiology (01-06-2022)“…Background Cardiac MRI features are not well-defined in immune checkpoint inhibitor (ICI)-induced myocarditis (ICI-M), a severe complication of ICI therapy in…”
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Clinical Features, Management, and Outcomes of Immune Checkpoint Inhibitor-Related Cardiotoxicity
Published in Circulation (New York, N.Y.) (21-11-2017)“…Immune checkpoint inhibitors (ICIs) represent a major advance in the treatment of cancer. Although clinical trials reported a low incidence of immune-related…”
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Effects of Amiodarone and Dronedarone on Voltage-Dependent Sodium Current in Human Cardiomyocytes
Published in Journal of cardiovascular electrophysiology (01-08-2003)“…Introduction: Amiodarone (AM) is a highly effective antiarrhythmic agent used in the management of both atrial and ventricular arrhythmias. Its noniodinated…”
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Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study
Published in Scientific reports (23-03-2022)“…Although epidemiologic research has demonstrated significant differences in incidence and outcomes of sepsis according to sex, their underlying biological…”
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Interactions between Gender and Sepsis-Implications for the Future
Published in Microorganisms (Basel) (14-03-2023)“…Sex and gender dimorphisms are found in a large variety of diseases, including sepsis and septic shock which are more prevalent in men than in women. Animal…”
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Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy
Published in PLoS genetics (06-07-2018)“…Left ventricular non-compaction (LVNC) is a rare cardiomyopathy associated with a hypertrabeculated phenotype and a large spectrum of symptoms. It is still…”
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Intensified immunosuppressive therapy in patients with immune checkpoint inhibitor-induced myocarditis
Published in Journal for immunotherapy of cancer (08-12-2020)“…BackgroundMyocarditis is a rare but life-threatening adverse event of cancer treatments with immune checkpoint inhibitors (ICIs). Recent guidelines recommend…”
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dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila
Published in PLoS genetics (01-11-2012)“…Cardiac aging is a complex process, which is influenced by both environmental and genetic factors. Deciphering the mechanisms involved in heart senescence…”
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Nkx2-5 Loss of Function in the His-Purkinje System Hampers Its Maturation and Leads to Mechanical Dysfunction
Published in Journal of cardiovascular development and disease (27-04-2023)“…The ventricular conduction or His-Purkinje system (VCS) mediates the rapid propagation and precise delivery of electrical activity essential for the…”
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Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation
Published in Biomedicines (01-11-2022)“…Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the…”
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Low Density Lipoprotein Cholesterol Decreases the Expression of Adenosine A2A Receptor and Lipid Rafts-Protein Flotillin-1: Insights on Cardiovascular Risk of Hypercholesterolemia
Published in Cells (Basel, Switzerland) (11-03-2024)“…High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in…”
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Adenosinergic System and Neuroendocrine Syncope: What Is the Link?
Published in Cells (Basel, Switzerland) (01-08-2023)“…Although very common, the precise mechanisms that explain the symptomatology of neuroendocrine syncope (NES) remain poorly understood. This disease, which can…”
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Control of Cardiac Rhythm by ORK1, a Drosophila Two-Pore Domain Potassium Channel
Published in Current biology (08-08-2006)“…Unravelling the mechanisms controlling cardiac automatism is critical to our comprehension of heart development and cardiac physiopathology. Despite the…”
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Analysis of cardiac dysfunction in a preclinical murine model of immune-mediated cardiotoxicity
Published in Archives of cardiovascular diseases (01-06-2024)“…Immunotherapies represent a major advance in oncology. However, activation of the immune system can lead to severe myocarditis with a fatality rate close to…”
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