Search Results - "Lala, Deepak S"

The Medicinal Chemistry of Liver X Receptor (LXR) Modulators by Tice, Colin M, Noto, Paul B, Fan, Kristi Yi, Zhuang, Linghang, Lala, Deepak S, Singh, Suresh B

“…LXRs have been of interest as targets for the treatment of atherosclerosis for over a decade. In recent years, LXR modulators have also garnered interest for…”
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The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor by Wu, Jun, Xia, Chunsheng, Meier, Jannika, Li, Suzhen, Hu, Xiao, Lala, Deepak S

“…Ayurveda, the ancient Indian system of health care and medicine, has a well-organized materia medica in which plants form a dominant part. A key illustration…”
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Activation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Oxysterols by Lala, Deepak S., Syka, Peter M., Lazarchik, Steven B., Mangelsdorf, David J., Parker, Keith L., Heyman, Richard A.

“…Steroidogenic factor 1 (SF-1), an orphan member of the intracellular receptor superfamily, plays an essential role in the development and function of multiple…”
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Repression of p65 Transcriptional Activation by the Glucocorticoid Receptor in the Absence of Receptor-Coactivator Interactions by Wu, Jun, Li, Yu, Dietz, Jessica, Lala, Deepak S

“…Glucocorticoids are among the most potent antiinflammatory agents, acting through the glucocorticoid receptor (GR) to suppress gene expression of a variety of…”
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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists by Lotesta, Stephen D., Marcus, Andrew P., Zheng, Yajun, Leftheris, Katerina, Noto, Paul B., Meng, Shi, Kandpal, Geeta, Chen, Guozhou, Zhou, Jing, McKeever, Brian, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S., Singh, Suresh B., McGeehan, Gerard M.

“…[Display omitted] Mineralocorticoid receptor (MR) antagonists continue to be a prevalent area of research in the pharmaceutical industry. Herein we report the…”
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Activation of specific RXR heterodimers by an antagonist of RXR homodimers by Lala, Deepak S, Mukherjee, Ranjan, Schulman, Ira G, Koch, Stacie S. Canan, Dardashti, Laura J, Nadzan, Alex M, Croston, Glenn E, Evans, Ronald M, Heyman, Richard A

“…Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent…”
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Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes by Hamilton, Bradford S., Himmelsbach, Frank, Nar, Herbert, Schuler-Metz, Annette, Krosky, Paula, Guo, Joan, Guo, Rong, Meng, Shi, Zhao, Yi, Lala, Deepak S., Zhuang, Linghang, Claremon, David A., McGeehan, Gerard M.

“…To combat the increased morbidity and mortality associated with the developing diabetes epidemic new therapeutic interventions are desirable. Inhibition of…”
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Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors by Noto, Paul B, Bukhtiyarov, Yuri, Shi, Meng, McKeever, Brian M, McGeehan, Gerard M, Lala, Deepak S

“…Liver X receptor (LXR) α and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and…”
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Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys by Hamilton, Bradford S., Schoelch, Corinna, Schuler-Metz, Annette, Krosky, Paula, Lala, Deepak S., Claremon, David A., McGeehan, Gerard M.

“…Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the…”
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The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor by Wu, Jun, Xia, Chunsheng, Meier, Jannika, Li, Suzhen, Hu, Xiao, Lala, Deepak S

“…Ayurveda, the ancient Indian system of health care and medicine, has a well-organized materia medica in which plants form a dominant part. A key illustration…”
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Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF by Hobson, Scott, Lenter, Martin C, Sauer, Achim, Fuchs, Klaus, Lala, Deepak S, Dillard, Lawrence W, Dorner-Ciossek, Cornelia

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Liver X Receptors Interact with Corepressors to Regulate Gene Expression by Hu, Xiao, Li, Suzhen, Wu, Jun, Xia, Chunsheng, Lala, Deepak S

“…Liver X receptors (LXRs) are members of the nuclear receptor superfamily that regulate gene expression in response to oxysterols and play a critical role in…”
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An Activin Receptor-Like Kinase 5 Inhibitor Reduces Collagen Deposition in a Rat Dermal Incision Wound Healing Model by Bian, Feng, Render, James, Ren, Xiao-Dan, Chio, Christopher, Chan, Kam, Boys, Mark, Lala, Deepak S., Pocalyko, David

“…Excessive dermal scarring is characterized by an overabundant deposition of extracellular matrix caused by fibrosis. The purpose of this study was to modify a…”
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Pharmacological characterization of the new bace1 inhibitor bi 1181181 by Dorner-Ciossek, Cornelia, Hobson, Scott, Fuchs, Klaus, Sauer, Achim, Bauer, Margit, Morales-Ramos, Angel, Venkatraman, Shankar, Dillard, Lawrence W, Kruk, Barbara, Howard, Lamont, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S

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Multiplexing nuclear receptors for agonist identification in a cell-based reporter gene high-throughput screen by Grover, G Scott, Turner, Benjamin A, Parker, Christian N, Meier, Jannika, Lala, Deepak S, Lee, Paul H

“…High-throughput screening (HTS) has become an essential part of the drug discovery process. Due to the rising requirements for both data quality and quantity,…”
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The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms by Hultman, Monica L, Krasnoperova, Nataliia V, Li, Suzhen, Du, Sarah, Xia, Chunsheng, Dietz, Jessica D, Lala, Deepak S, Welsch, Dean J, Hu, Xiao

“…We investigated the coregulator (coactivator and corepressor) interactions with the mineralocorticoid receptor (MR) that lead to activation and inhibition of…”
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Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring by Boys, Mark L., Bian, Feng, Kramer, James B., Chio, Christopher L., Ren, Xiao-Dan, Chen, Huifen, Barrett, Stephen D., Sexton, Karen E., Iula, Donna M., Filzen, Gary F., Nguyen, Maria N., Angell, Paul, Downs, Victoria L., Wang, Zhi, Raheja, Neil, Ellsworth, Edmund L., Fakhoury, Stephen, Bratton, Larry D., Keller, Paul R., Gowan, Richard, Drummond, Elena M., Maiti, Samarendra N., Hena, Mostofa A., Lu, Leroy, McConnell, Patrick, Knafels, John D., Thanabal, Venkataraman, Sun, Fang, Alessi, Diane, McCarthy, Ann, Zhang, Erli, Finzel, Barry C., Patel, Sneha, Ciotti, Susan M., Eisma, Rone, Payne, N.A., Gilbertsen, Richard B., Kostlan, Catherine R., Pocalyko, David J., Lala, Deepak S.

“…Application of PF-03671148 to rat wounds leads to a dose dependent inhibition of multiple fibrotic genes in vivo. A series of 2-(1H-pyrazol-1-yl)pyridines are…”
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Steroidogenic factor 1: an essential mediator of endocrine development by Parker, Keith L, Rice, Douglas A, Lala, Deepak S, Ikeda, Yayoi, Luo, Xunrong, Wong, Margaret, Bakke, Marit, Zhao, Liping, Frigeri, Claudia, Hanley, Neil A, Stallings, Nancy, Schimmer, Bernard P

“…The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine…”
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The liver X receptors by Lala, Deepak S

“…The liver X receptors (LXRs), members of the nuclear receptor superfamily, are potential targets for a variety of diseases. While there are many opportunities…”
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Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone by Hu, Xiao, Li, Suzhen, McMahon, Ellen G, Lala, Deepak S, Rudolph, Amy E

“…Mineralocorticoid receptor (MR) antagonism has proven to effectively attenuate the pathophysiological effects of aldosterone in clinical and experimental…”
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