Search Results - "Lal, Shruti"

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells by Zarei, Mahsa, Lal, Shruti, Parker, Seth J, Nevler, Avinoam, Vaziri-Gohar, Ali, Dukleska, Katerina, Mambelli-Lisboa, Nicole C, Moffat, Cynthia, Blanco, Fernando F, Chand, Saswati N, Jimbo, Masaya, Cozzitorto, Joseph A, Jiang, Wei, Yeo, Charles J, Londin, Eric R, Seifert, Erin L, Metallo, Christian M, Brody, Jonathan R, Winter, Jordan M

“…Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote…”
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Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors by Chand, Saswati N, Zarei, Mahsa, Schiewer, Matthew J, Kamath, Akshay R, Romeo, Carmella, Lal, Shruti, Cozzitorto, Joseph A, Nevler, Avinoam, Scolaro, Laura, Londin, Eric, Jiang, Wei, Meisner-Kober, Nicole, Pishvaian, Michael J, Knudsen, Karen E, Yeo, Charles J, Pascal, John M, Winter, Jordan M, Brody, Jonathan R

“…The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show…”
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HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells by LAI, Shruti, BURKHART, Richard A, SAWICKI, Janet A, WINTER, Jordan M, RIGOUTSOS, Isidore, YEN, Timothy J, BRODY, Jonathan R, BEEHARRY, Neil, BHATTACHARJEE, Vikram, LONDIN, Eric R, COZZITORTO, Joseph A, ROMEO, Carmella, JIMBO, Masaya, NORRIS, Zoë A, YEO, Charles J

“…HuR (ELAV1), an RNA-binding protein abundant in cancer cells, primarily resides in the nucleus, but under specific stress (e.g., gemcitabine), HuR translocates…”
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CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype by Lal, Shruti, Cheung, Edwin C, Zarei, Mahsa, Preet, Ranjan, Chand, Saswati N, Mambelli-Lisboa, Nicole C, Romeo, Carmella, Stout, Matthew C, Londin, Eric, Goetz, Austin, Lowder, Cinthya Y, Nevler, Avinoam, Yeo, Charles J, Campbell, Paul M, Winter, Jordan M, Dixon, Dan A, Brody, Jonathan R

“…Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most…”
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WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner by Lal, Shruti, Zarei, Mahsa, Chand, Saswati N., Dylgjeri, Emanuela, Mambelli-Lisboa, Nicole C., Pishvaian, Michael J., Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, in part, because of the lack of effective targeted therapeutic options. MK-1775 (also known as…”
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The Role of PENNYWISE and POUND-FOOLISH in the Maintenance of the Shoot Apical Meristem in Arabidopsis by Ung, Nolan, Lal, Shruti, Smith, Harley M.S.

“…Growth of the aerial part of the plant is dependent upon the maintenance of the shoot apical meristem (SAM). A balance between the self-renewing stem cells in…”
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1359 NTX-0471, engineered multivalent SIRPa and bispecific SIRPa-antiCCR4 molecules demonstrate superior activity providing path for mRNA expressed in-vivo biologics by Kannan, Gunasekaran, Sallets, Adrienne, Adusumilli, Gowrisudha, Bandi, Srinivasa, Lal, Shruti, Low, Ray, Liu, Weiqun, Haabeth, Ole Audun, McKinlay, Colin, Hsu, Pei-Ken, Ferry, Kimmy, Sharma, Anustha, Triplett, Jenna, Leong, Meredith, McCartney-Melstad, Evan, Deutsch, Samuel

“…BackgroundA transformative approach to medicine involves expressing complex and therapeutically relevant biologics utilizing patients’ own body and tissues via…”
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Crawling through time: Transition of snails to slugs dating back to the Paleozoic, based on mitochondrial phylogenomics by Medina, Mónica, Lal, Shruti, Vallès, Yvonne, Takaoka, Tori L., Dayrat, Benoît A., Boore, Jeffrey L., Gosliner, Terrence

“…Sea slugs (Gastropoda: Opisthobranchia) are characterized by extensive morphological homoplasy. In particular, reduced or absent shells are predominant…”
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RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer by Zarei, Mahsa, Lal, Shruti, Vaziri-Gohar, Ali, O'Hayer, Kevin, Gunda, Venugopal, Singh, Pankaj K, Brody, Jonathan R, Winter, Jordan M

“…Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic enzyme in human malignancy. A heterozygous genetic alteration, arginine 132, promotes…”
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Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival by Burkhart, Richard A, Peng, Yu, Norris, Zoë A, Tholey, Renée M, Talbott, Vanessa A, Liang, Qin, Ai, Yongxing, Miller, Kathy, Lal, Shruti, Cozzitorto, Joseph A, Witkiewicz, Agnieska K, Yeo, Charles J, Gehrmann, Matthew, Napper, Andrew, Winter, Jordan M, Sawicki, Janet A, Zhuang, Zhihao, Brody, Jonathan R

“…Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States, with a 95% five-year mortality rate. For over…”
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Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer by STEFFEN, Jamin D, THOLEY, Renee M, PASCAL, John M, LANGELIER, Marie-France, PLANCK, Jamie L, SCHIEWER, Matthew J, LAL, Shruti, BILDZUKEWICZ, Nikolai A, YEO, Charles J, KNUDSEN, Karen E, BRODY, Jonathan R

“…PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity. During genotoxic stress, PARP-1 recruits to sites of DNA damage where…”
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Abstract 1656: MK-1775 (WEE1 inhibition) lacks efficacy against DNA repair deficient pancreatic cancer cells by Lal, Shruti, Chand, Saswati N., Dylgjeri, Emanuela, Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

“…Introduction: In this study, we explored the possibility of developing a personalized approach of using MK-1775, a potent WEE1 inhibitor, as mono- or…”
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Abstract 4441: Functional and clinical implications of an INDEL within the HuR regulatory region of the mitotic kinase inhibitor WEE1 by Brown, Samantha Z., Nevler, Avinoam, Thomsett, Henry T., Lal, Shruti, Zarei, Mahsa, Blanco, Fernando, Cozzitorto, Joseph A., Norris-Kirby, Alexis L., Yeo, Charles J., Winter, Jordan M., Eshleman, James R., Brody, Jonathan R.

“…The RNA-binding protein Human Antigen R (HuR) is upregulated in pancreatic ductal adenocarcinoma (PDA), where it promotes tumorigenesis via its mRNA…”
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Gut microbiome dysbiosis in inflammatory bowel disease by Lal, Shruti, Kandiyal, Bharti, Ahuja, Vineet, Takeda, Kiyoshi, Das, Bhabatosh

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Regulation of the SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE genes/microRNA156 Module by the Homeodomain Proteins PENNYWISE and POUND-FOOLISH in Arabidopsis by Lal, Shruti, Pacis, Leo Bryan, Smith, Harley M.S.

“…The morphology of inflorescences is regulated in part by the temporal and spatial events that regulate flower specification. In Arabidopsis, an endogenous…”
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Abstract 2594: Discovery and characterization of ZL-2201, a potent, highly-selective, and orally bioavailable small-molecule DNA-PK inhibitor by Lal, Shruti, Sun, Bee-Chun, Chen, Yuping, Huang, Tom, Bhola, Neil, Morton, Vivian, Chen, Kevin, Xia, Shanghua, Zhang, Haoyu, Ye, Qiuping, Veiby, Petter, Bellovin, David I., Ji, Yuhua

“…DNA-damaging poisons and replicative stress commonly result in increased double-strand breaks (DSBs) in tumor cells. Non-homologous end joining (NHEJ), driven…”
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Abstract 6725: NTX-470, a novel multispecific T cell engager expressed from mRNA targets PSMA and STEAP1 prostate cancer antigens to generate enhanced functional activity by Rae, Chris, Adusumilli, Sudha, Bandi, Srinivasa, Lal, Shruti, Dhungel, Pragyesh, Ferry, Kimmy, Gholizadeh, Shima, Sharma, Anushtha, Sallets, Adrienne, Liu, Weiqun, McCartney-Melstad, Evan, Hsu, Pei-Ken, Low, Ray, McKinlay, Colin, Leong, Meredith, Oh, David Y., Fong, Lawrence, Kannan, Guna, Deutsch, Samuel, Haabeth, Ole

“…Prostate cancer is the most common cancer in American men and the second leading cause of cancer death in men in western countries. Most metastatic patients…”
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dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: A dual-institutional follow-up with the RTOG 9704 trial by McAllister, Florencia, Pineda, Danielle M, Jimbo, Masaya, Lal, Shruti, Burkhart, Richard A, Moughan, Jennifer, Winter, Kathryn A, Abdelmohsen, Kotb, Gorospe, Myriam, de Jesus Acosta, Ana, Lankapalli, Rachana H, Winter, Jordan M, Yeo, Charles J, Witkiewicz, Agnieska K, Iacobuzio-Donahue, Christine A, Laheru, Daniel, Brody, Jonathan R

“…Deoxycytidine kinase (dCK) and human antigen R (HuR) have been associated with response to gemcitabine in small studies. The present study investigates the…”
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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor by Lal, Shruti, Bhola, Neil E., Sun, Bee-Chun, Chen, Yuping, Huang, Tom, Morton, Vivian, Chen, Kevin X., Xia, Shanghua, Zhang, Haoyu, Parikh, Nehal S., Ye, Qiuping, Veiby, O. Petter, Bellovin, David I., Ji, Yuhua

“…DNA-dependent protein kinase (DNA-PK), a driver of the non-homologous end-joining (NHEJ) DNA damage response pathway, plays an instrumental role in repairing…”
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Abstract 2854: CRISPR knockout of HuR in pancreatic cancer cells causes a xenograft lethal phenotype by Cheung, Edwin, Lal, Shruti, Zarei, Mahsa, Mambelli-Lisboa, Nicole C., Chand, Saswati, Romeo, Carmella, O’Hayer, Kevin, Londin, Eric, Cozzitorto, Joseph A., Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.

“…Pancreatic ductal adenocarcinoma (PDA) is the most prevalent type of pancreatic cancer and will soon become the second leading cause of cancer related deaths…”
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