Search Results - "Lal, Ritu"

Interindividual Variability in the Bioavailability of Gabapentin Enacarbil Extended Release in Healthy Adults: An Analysis of Data From 6 Phase I Studies by Lal, Ritu, Ellenbogen, Aaron, Gidal, Barry

“…The absorption and bioavailability of oral gabapentin are associated with a high degree of interindividual variability. Gabapentin enacarbil, a prodrug of…”
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Population Pharmacokinetics and Pharmacodynamics of Gabapentin After Administration of Gabapentin Enacarbil by Lal, Ritu, Sukbuntherng, Juthamas, Luo, Wendy, Tovera, James, Lassauzet, Marie Liesse, Cundy, Kenneth C.

“…Gabapentin enacarbil (GEn) is an actively transported prodrug of gabapentin that provides sustained dose‐proportional exposure to gabapentin and predictable…”
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Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen by Lal, Ritu, Sukbuntherng, Juthamas, Tai, Ezra H L, Upadhyay, Shubhra, Yao, Fenmei, Warren, Mark S, Luo, Wendy, Bu, Lin, Nguyen, Son, Zamora, Jeanelle, Peng, Ge, Dias, Tracy, Bao, Ying, Ludwikow, Maria, Phan, Thu, Scheuerman, Randall A, Yan, Hui, Gao, Mark, Wu, Quincey Q, Annamalai, Thamil, Raillard, Stephen P, Koller, Kerry, Gallop, Mark A, Cundy, Kenneth C

“…Baclofen is a racemic GABA(B) receptor agonist that has a number of significant pharmacokinetic limitations, including a narrow window of absorption in the…”
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Clinical Pharmacokinetics of Gabapentin After Administration of Gabapentin Enacarbil Extended-Release Tablets in Patients With Varying Degrees of Renal Function Using Data From an Open-Label, Single-Dose Pharmacokinetic Study by Lal, Ritu, PhD, Sukbuntherng, Juthamas, PhD, Luo, Wendy, MS, Chen, Dan, MD, PhD, Blumenthal, Robin, PhD, Ho, Judy, BS, Cundy, Kenneth C., PhD

“…Abstract Background Gabapentin enacarbil, a transported acyloxyalkylcarbamate prodrug of gabapentin, provides predictable and dose-proportional gabapentin…”
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Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: A randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers by Lal, Ritu, PhD, Sukbuntherng, Juthamas, PhD, Luo, Wendy, MS, Chen, Dan, MD, PhD, Vu, Amanda, MS, Tovera, James, BS, Cundy, Kenneth C., PhD

“…Abstract Background: Gabapentin enacarbil is an actively transported prodrug of gabapentin that provides predictable dose-proportional gabapentin exposure with…”
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Evaluation of Gabapentin Enacarbil on Cardiac Repolarization: A Randomized, Double-Blind, Placebo- and Active-Controlled, Crossover Thorough QT/QTc Study in Healthy Adults by Chen, Dan, MD, PhD, Lal, Ritu, PhD, Zomorodi, Katie, PhD, Atluri, Harisha, PhD, Ho, Judy, BS, Luo, Wendy, MS, Tovera, James, BS, Bonzo, Daniel, PhD, Cundy, Kenneth, PhD

“…Abstract Background Gabapentin enacarbil, a transported prodrug of gabapentin, was recently approved by the US Food and Drug Administration for the treatment…”
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ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease by SHAM, H. L, KEMPF, D. J, BETEBENNER, D, KORNEYEVA, M, VASAVANONDA, S, MCDONALD, E, SALDIVAR, A, WIDEBURG, N, XIAOOI CHEN, PING NIU, CHANG PARK, JAYANTI, V, MOLLA, A, GRABOWSKI, B, GRANNEMAN, G. R, SUN, E, JAPOUR, A. J, LEONARD, J. M, PLATTNER, J. J, NORBECK, D. W, MARSH, K. C, KUMAR, G. N, CHEN, C.-M, KATI, W, STEWART, K, LAL, R, HSU, A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Influence of cardiac output on dexmedetomidine pharmacokinetics by Dutta, S, Lal, R, Karol, M D, Cohen, T, Ebert, T

“…Dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, reduces the requirements for anesthetic, analgesic, sedative, and hypnotic drugs…”
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Interindividual Variability in the Bioavailability of Gabapentin Enacarbil Extended Release in Healthy Adults: An Analysis of Data From Six Phase I Studies by Lal, Ritu, Ellenbogen, Aaron, Gidal, Barry

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The pharmacokinetics and pharmacodynamics of dexamethasone following epidural SP-102 or intravenous dexamethasone sodium phosphate injection in subjects with lumbosacral radicular pain by Yee, Shiyin, Robson, Richard, Stannard, Elizabeth, Lal, Ritu, Lissin, Dmitri

“…Objectives: To evaluate the pharmacokinetics, pharmacodynamics (PD), safety, and tolerability of epidural SP-102 (10 mg dexamethasone sodium phosphate…”
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Pharmacokinetics of immediate release, extended release, and gastric retentive gabapentin formulations in healthy adults by Swearingen, Dennis, Aronoff, Gerald M, Ciric, Sabrina, Lal, Ritu

“…Gabapentin immediate release (GBP-IR), gabapentin gastric retentive (GBP-GR), and the prodrug gabapentin enacarbil extended release formulation (GEn) have been…”
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Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: A comparison with intravenous methylprednisolone by Lal, Ritu, Bell, Stacie, Challenger, Rashida, Hammock, Vakessa, Nyberg, Mary, Decker, Dima, Becker, Patrice M., Young, David

“…Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflammatory…”
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Arbaclofen Placarbil Decreases Postprandial Reflux in Patients With Gastroesophageal Reflux Disease by GERSON, Lauren B, JACOB HUFF, F, HILA, Amine, HIROTA, William K, REILLEY, Sandra, AGRAWAL, Amit, LAL, Ritu, LUO, Wendy, CASTELL, Donald

“…Arbaclofen placarbil (AP), previously designated as XP19986, is an investigational prodrug of the active R-isomer of baclofen, a gamma-aminobutyric acid…”
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Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine by Lal, Ritu, Sukbuntherng, Juthamas, Luo, Wendy, Vicente, Virna, Blumenthal, Robin, Ho, Judy, Cundy, Kenneth C.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Gabapentin enacarbil is a transported prodrug of gabapentin that provides sustained, dose‐proportional exposure to…”
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Actively transported levodopa prodrug XP21279: a study in patients with Parkinson disease who experience motor fluctuations by Lewitt, Peter A, Ellenbogen, Aaron, Chen, Dan, Lal, Ritu, McGuire, Kristin, Zomorodi, Katie, Luo, Wendy, Huff, F Jacob

“…The objectives of this study were to assess the pharmacokinetic profile, efficacy, and safety of XP21279 administered with carbidopa (CD) in subjects with…”
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A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome by Lal, Ritu, Ellenbogen, Aaron, Chen, Dan, Zomorodi, Katie, Atluri, Harisha, Luo, Wendy, Tovera, James, Hurt, Janet, Bonzo, Daniel, Lassauzet, Marie-Liesse, Vu, Amanda, Cundy, Kenneth C

“…The objective of this study was to determine steady-state gabapentin exposures and corresponding relief of symptoms and safety profile produced by 4 dose…”
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A Clinical Pharmacokinetic Drug-Drug Interaction Study of Arbaclofen Placarbil, a Novel Reflux Inhibitor, With Esomeprazole: 13 by Lal, Ritu, Zomorodi, Katie, Sukbuntherng, Juthamas, Luo, Wendy, Tovera, James, Fontaine, Jacki, Cavazos, Nora, Bonzo, Daniel, Cundy, Kenneth

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W1105 Clinical Pharmacokinetics and Pharmacodynamics of Arbaclofen Placarbil, a Novel Reflux Inhibitor, in Subjects With GERD by Lal, Ritu, Kshirsagar, Smita, Huff, F Jacob, Luo, Wendy, Tovera, James, Blumenthal, Robin, Bian, Amy, Cundy, Kenneth C

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Evaluation of the Effect of Arbaclofen Placarbil, a Novel Transported Prodrug of R-Baclofen, on Cardiac Repolarization in a Thorough QT Study in Healthy Subjects: 42 by Chen, Dan, Lal, Ritu, Huff, Jacob F., Sukbuntherng, Juthamas, Luo, Wendy, Tovera, James, Ho, Judy, Cavazos, Nora, Bonzo, Daniel, Cundy, Kenneth

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Clinical Evaluation of Xp19986 as a Potential Treatment for GERD: 25 by Huff, F. Jacob, Lal, Ritu, Sukbuntherng, Juthamas, Luo, Wendy, Tovera, James, Blumenthal, Robin, Lassauzet, Marie-Liesse Lassauzet, Navvab, Zarrin, Cundy, Kenneth

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