Search Results - "Lal, Nathaniel"

Vascular Endothelial Growth Factor B and Its Signaling by Lal, Nathaniel, Puri, Karanjit, Rodrigues, Brian

“…In diabetes, compromised glucose utilization leads the heart to use FA almost exclusively for ATP generation. Chronically, this adaptation unfortunately leads…”
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Diabetes Mellitus Severity and a Switch From Using Lipoprotein Lipase to Adipose-Derived Fatty Acid Results in a Cardiac Metabolic Signature That Embraces Cell Death by Puri, Karanjit, Lal, Nathaniel, Shang, Rui, Ghosh, Sanjoy, Flibotte, Stephane, Dyer, Roger, Hussein, Bahira, Rodrigues, Brian

“…Background Fatty acid (FA) provision to the heart is from cardiomyocyte and adipose depots, plus lipoprotein lipase action. We tested how a graded reduction in…”
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Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart by Shang, Rui, Lal, Nathaniel, Lee, Chae Syng, Zhai, Yajie, Puri, Karanjit, Seira, Oscar, Boushel, Robert C, Sultan, Ibrahim, Räsänen, Markus, Alitalo, Kari, Hussein, Bahira, Rodrigues, Brian

“…Cardiac muscle uses multiple sources of energy including glucose and fatty acid (FA). The heart cannot synthesize FA and relies on obtaining it from other…”
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Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling by Lal, Nathaniel, Chiu, Amy Pei-Ling, Wang, Fulong, Zhang, Dahai, Jia, Jocelyn, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…Vascular endothelial growth factor B (VEGFB) is highly expressed in metabolically active tissues, such as the heart and skeletal muscle, suggesting a function…”
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Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus by Chiu, Amy Pei-Ling, Wan, Andrea, Lal, Nathaniel, Zhang, Dahai, Wang, Fulong, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…OBJECTIVE—Lipoprotein lipase (LPL)–mediated triglyceride hydrolysis is the major source of fatty acid for cardiac energy. LPL, synthesized in cardiomyocytes,…”
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Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity by Chiu, Amy Pei-Ling, Bierende, Denise, Lal, Nathaniel, Wang, Fulong, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…In the diabetic heart, there is excessive dependence on fatty acid (FA) utilization to generate ATP. Lipoprotein lipase (LPL)-mediated hydrolysis of…”
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High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature by Wang, Fulong, Jia, Jocelyn, Lal, Nathaniel, Zhang, Dahai, Chiu, Amy Pei-Ling, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…The secretion of enzymatically active heparanase (Hep ) has been implicated as an essential metabolic adaptation in the heart following diabetes. However, the…”
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Hyperglycemia-Induced Secretion of Endothelial Heparanase Stimulates a Vascular Endothelial Growth Factor Autocrine Network in Cardiomyocytes That Promotes Recruitment of Lipoprotein Lipase by Zhang, Dahai, Wan, Andrea, Chiu, Amy Pei-Ling, Wang, Ying, Wang, Fulong, Neumaier, Katharina, Lal, Nathaniel, Bround, Michael J, Johnson, James D, Vlodavsky, Israel, Rodrigues, Brian

“…OBJECTIVE—During diabetes mellitus, coronary lipoprotein lipase increases to promote the predominant use of fatty acids. We have reported that high glucose…”
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Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes by YING WANG, CHIU, Amy Pei-Ling, RODRIGUES, Brian, NEUMAIER, Katharina, FULONG WANG, DAHAI ZHANG, HUSSEIN, Bahira, LAL, Nathaniel, WAN, Andrea, LIU, George, VLODAVSKY, Israel

“…After diabetes, the heart has a singular reliance on fatty acid (FA) for energy production, which is achieved by increased coronary lipoprotein lipase (LPL)…”
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Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1 by Pei-Ling Chiu, Amy, Wang, Fulong, Lal, Nathaniel, Wang, Ying, Zhang, Dahai, Hussein, Bahira, Wan, Andrea, Vlodavsky, Israel, Rodrigues, Brian

“…In diabetes, when glucose uptake and oxidation are impaired, the heart is compelled to use fatty acid (FA) almost exclusively for ATP. The vascular content of…”
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Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes by Zhang, Dahai, Wang, Fulong, Lal, Nathaniel, Chiu, Amy Pei-Ling, Wan, Andrea, Jia, Jocelyn, Bierende, Denise, Flibotte, Stephane, Sinha, Sunita, Asadi, Ali, Hu, Xiaoke, Taghizadeh, Farnaz, Pulinilkunnil, Thomas, Nislow, Corey, Vlodavsky, Israel, Johnson, James D, Kieffer, Timothy J, Hussein, Bahira, Rodrigues, Brian

“…Heparanase, a protein with enzymatic and nonenzymatic properties, contributes toward disease progression and prevention. In the current study, a fortuitous…”
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