Search Results - "Lal, Mark"

Understanding Podocyte Biology to Develop Novel Kidney Therapeutics by Lal, Mark A, Patrakka, Jaakko

“…Over the past two decades it has become increasing clear that injury and loss of podocytes is an early and common clinical observation presented in many forms…”
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Targeting the podocyte to treat glomerular kidney disease by Lal, Mark A., Young, Kenneth W., Andag, Uwe

“…•The podocyte is the final cellular determinant of glomerular filtration in the kidney.•Podocyte dysfunction characterizes chronic kidney diseases of…”
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Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes by He, Bing, Chen, Ping, Zambrano, Sonia, Dabaghie, Dina, Hu, Yizhou, Möller-Hackbarth, Katja, Unnersjö-Jess, David, Korkut, Gül Gizem, Charrin, Emmanuelle, Jeansson, Marie, Bintanel-Morcillo, Maria, Witasp, Anna, Wennberg, Lars, Wernerson, Annika, Schermer, Bernhard, Benzing, Thomas, Ernfors, Patrik, Betsholtz, Christer, Lal, Mark, Sandberg, Rickard, Patrakka, Jaakko

“…Molecular characterization of the individual cell types in human kidney as well as model organisms are critical in defining organ function and understanding…”
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Regulated intramembrane proteolysis: signaling pathways and biological functions by Lal, Mark, Caplan, Michael

“…Intramembrane cleavage of transmembrane proteins is a fundamental cellular process. Several enzymes capable of releasing domains of integral membrane proteins…”
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Unraveling the role of natriuretic peptide clearance receptor (NPR3) in glomerular diseases by Dabaghie, Dina, Charrin, Emmanuelle, Tonelius, Pernilla, Rosengren, Birgitta, Korkut, Gizem, Granqvist, Anna B., Lal, Mark, Patrakka, Jaakko

“…Natriuretic peptides (NPs) are cardio-derived hormones that have a crucial role in maintaining cardiovascular homeostasis. Physiological effects of NPs are…”
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Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration by Lal, Mark A, Andersson, Ann-Charlotte, Katayama, Kan, Xiao, Ziejie, Nukui, Masatoshi, Hultenby, Kjell, Wernerson, Annika, Tryggvason, Karl

“…Rhophilin-1 is a Rho GTPase-interacting protein, the biologic function of which is largely unknown. Here, we identify and describe the functional role of…”
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Knocking out podocyte rho GTPases: and the winner is by Lal, Mark A, Tryggvason, Karl

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APOL1 promotes endothelial cell activation beyond the glomerulus by Carracedo, Miguel, Ericson, Elke, Ågren, Rasmus, Forslöw, Anna, Madeyski-Bengtson, Katja, Svensson, Anna, Riddle, Rebecca, Christoffersson, Jonas, González-King Garibotti, Hernán, Lazovic, Bojana, Hicks, Ryan, Buvall, Lisa, Fornoni, Alessia, Greasley, Peter J., Lal, Mark

“…Apolipoprotein L1 (APOL1) high-risk genotypes are associated with increased risk of chronic kidney disease (CKD) in people of West African ancestry. Given the…”
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Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin by Perisic, Ljubica, Rodriguez, Patricia Q, Hultenby, Kjell, Sun, Ying, Lal, Mark, Betsholtz, Christer, Uhlén, Mathias, Wernerson, Annika, Hedin, Ulf, Pikkarainen, Timo, Tryggvason, Karl, Patrakka, Jaakko

“…Podocyte foot process effacement accompanied by actin cytoskeleton rearrangements is a cardinal feature of many progressive human proteinuric diseases. By…”
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Ouabain, A Steroid Hormone That Signals with Slow Calcium Oscillations by Aizman, Oleg, Uhlén, Per, Lal, Mark, Brismar, Hjalmar, Aperia, Anita

“…The plant-derived steroid, digoxin, a specific inhibitor of Na,K-ATPase, has been used for centuries in the treatment of heart disease. Recent studies…”
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Analysis of Mice Lacking the Heparin-Binding Splice Isoform of Platelet-Derived Growth Factor A by Andrae, Johanna, Ehrencrona, Hans, Gallini, Radiosa, Lal, Mark, Ding, Hao, Betsholtz, Christer

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Na,K-ATPase signal transduction triggers CREB activation and dendritic growth by Desfrere, Luc, Karlsson, Marie, Hiyoshi, Hiromi, Malmersjö, Seth, Nanou, Evanthia, Estrada, Manuel, Miyakawa, Ayako, Lagercrantz, Hugo, El Manira, Abdeljabbar, Lal, Mark, Uhlén, Per

“…Dendritic growth is pivotal in the neurogenesis of cortical neurons. The sodium pump, or Na,K-ATPase, is an evolutionarily conserved protein that, in addition…”
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Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations by Miyakawa-Naito, Ayako, Uhlén, Per, Lal, Mark, Aizman, Oleg, Mikoshiba, Katsuhiko, Brismar, Hjalmar, Zelenin, Sergey, Aperia, Anita

“…Recent studies indicate novel roles for the ubiquitous ion pump, Na,K-ATPase, in addition to its function as a key regulator of intracellular sodium and…”
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Role of oxidative stress in advanced glycation end product-induced mesangial cell activation by Lal, Mark A., Brismar, Hjalmar, Eklöf, Ann-Christine, Aperia, Anita

“…Role of oxidative stress in advanced glycation end product-induced mesangial cell activation. Levels of advanced glycation end products (AGE) are elevated in…”
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Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin by Perisic, Ljubica, Rodriguez, Patricia Q, Hultenby, Kjell, Sun, Ying, Lal, Mark, Betsholtz, Christer, Uhlén, Mathias, Wernerson, Annika, Hedin, Ulf, Pikkarainen, Timo, Tryggvason, Karl, Patrakka, Jaakko

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Neph1 Is Reduced in Primary Focal Segmental Glomerulosclerosis, Minimal Change Nephrotic Syndrome, and Corresponding Experimental Animal Models of Adriamycin-Induced Nephropathy and Puromycin Aminonucleoside Nephrosis by Hulkko, Jenny, Patrakka, Jaakko, Lal, Mark, Tryggvason, Karl, Hultenby, Kjell, Wernerson, Annika

“…Background/Aims: The transmembrane proteins Neph1 and nephrin form a complex in the slit diaphragm (SD) of podocytes. As recent studies indicate an involvement…”
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Therapeutic Blocking of NPRC, a Podocyte-Expressed Target, Is Kidney Protective in ZSF1 Rats: FR-PO696 by Lal, Mark, Dabaghie, Dina, Charrin, Emmanuelle, Tonelius, Pernilla, Rosengren, Birgitta E., Granqvist, Anna, Patrakka, Jaakko

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1437 Renal expression pattern of the relaxin receptor, RXFP1, and effects of the RXFP1 agonist, AZD5462, on renin in non-human primates and humans by Lal, Mark, Ryberg, Erik, Althage, Magnus, Bergström, Fredrik, Hansen, Pernille B L, Pettersen, Daniel, Connolly, Kat, Rosenmeier, Jaya

“…Abstract Background and Aims RXFP1 is a G protein-coupled receptor (GPCR) for the pregnancy hormone, relaxin. While preclinical studies, performed primarily in…”
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RXFP1, the Relaxin Receptor, Is a Therapeutic Target Expressed in the Human Kidney, Not Rodent: SA-PO270 by Lal, Mark, Eddy, Sean, Hodgin, Jeffrey B., Althage, Magnus, Hansen, Pernille B. Laerkegaard, Patrakka, Jaakko, Kretzler, Matthias

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Molecular insights into the early stage of glomerular injury in IgA nephropathy using single-cell RNA sequencing by Zambrano, Sonia, He, Liqun, Kano, Toshiki, Sun, Ying, Charrin, Emmanuelle, Lal, Mark, Betsholtz, Christer, Suzuki, Yusuke, Patrakka, Jaakko

“…IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and defined by the presence of IgA-containing immune complexes in the mesangium…”
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