Search Results - "Lal, Kerri G."

The CD4⁻CD8⁻ MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8⁺ MAIT cell pool by Dias, Joana, Boulouis, Caroline, Gorin, Jean-Baptiste, van den Biggelaar, Robin H. G. A., Lal, Kerri G., Gibbs, Anna, Loh, Liyen, Gulam, Muhammad Yaaseen, Sia, Wan Rong, Bari, Sudipto, Hwang, William Y. K., Nixon, Douglas F., Nguyen, Son, Betts, Michael R., Buggert, Marcus, Eller, Michael A., Broliden, Kristina, Tjernlund, Annelie, Sandberg, Johan K., Leeansyah, Edwin

“…Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the MHC class…”
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Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination by Costanzo, Margaret C., Kim, Dohoon, Creegan, Matthew, Lal, Kerri G., Ake, Julie A., Currier, Jeffrey R., Streeck, Hendrik, Robb, Merlin L., Michael, Nelson L., Bolton, Diane L., Steers, Nicholas J., Eller, Michael A.

“…Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing…”
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Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells by Dias, Joana, Boulouis, Caroline, Sobkowiak, Michał J, Lal, Kerri G, Emgård, Johanna, Buggert, Marcus, Parrot, Tiphaine, Gorin, Jean-Baptiste, Leeansyah, Edwin, Sandberg, Johan K

“…Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic…”
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OMIP‐027: Functional analysis of human natural killer cells by Costanzo, Margaret C., Creegan, Matthew, Lal, Kerri G., Eller, Michael A.

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Informing the Need for a SARS-CoV-2 Booster Based on the Immune Responses Among Young Healthy Adults to Variants Circulating in Late 2023 by Nguyen, Huy C, Lal, Kerri G, Balinsky, Corey A, Hontz, Robert D, Lin, Jin, Beye, Matthew J, Smith, Lauren, Pan, Li, Cheng, Ying, Fox, Isabella, Lizewski, Stephen E, Foo, Hayley S, Krebs, Shelly J, Sun, Peifang, Letizia, Andrew G

“…Abstract Background COVID-19 remains a global public health challenge due to new immune-evasive SARS-CoV-2 variants and heterogeneous immunity. Methods In this…”
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Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity by Jensen, Jaime L, Sankhala, Rajeshwer S, Dussupt, Vincent, Bai, Hongjun, Hajduczki, Agnes, Lal, Kerri G, Chang, William C, Martinez, Elizabeth J, Peterson, Caroline E, Golub, Emily S, Rees, Phyllis A, Mendez-Rivera, Letzibeth, Zemil, Michelle, Kavusak, Erin, Mayer, Sandra V, Wieczorek, Lindsay, Kannan, Shruthi, Doranz, Benjamin J, Davidson, Edgar, Yang, Eun Sung, Zhang, Yi, Chen, Man, Choe, Misook, Wang, Lingshu, Gromowski, Gregory D, Koup, Richard A, Michael, Nelson L, Polonis, Victoria R, Rolland, Morgane, Modjarrad, Kayvon, Krebs, Shelly J, Joyce, M Gordon

“…Novel therapeutic monoclonal antibodies (MAbs) must accommodate comprehensive breadth of activity against diverse sarbecoviruses and high neutralization…”
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Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection by Lal, Kerri G., Kim, Dohoon, Costanzo, Margaret C., Creegan, Matthew, Leeansyah, Edwin, Dias, Joana, Paquin-Proulx, Dominic, Eller, Leigh Anne, Schuetz, Alexandra, Phuang-ngern, Yuwadee, Krebs, Shelly J., Slike, Bonnie M., Kibuuka, Hannah, Maganga, Lucas, Nitayaphan, Sorachai, Kosgei, Josphat, Sacdalan, Carlo, Ananworanich, Jintanat, Bolton, Diane L., Michael, Nelson L., Shacklett, Barbara L., Robb, Merlin L., Eller, Michael A., Sandberg, Johan K.

“…Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the…”
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A flow cytometry based assay that simultaneously measures cytotoxicity and monocyte mediated antibody dependent effector activity by Alrubayyi, Aljawharah, Schuetz, Alexandra, Lal, Kerri G., Jongrakthaitae, Surat, Paolino, Kristopher M., Ake, Julie A., Robb, Merlin L., de Souza, Mark S., Michael, Nelson L., Paquin-Proulx, Dominic, Eller, Michael A.

“…Antibody effector functions such as antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP) are considered…”
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Terminal Effector CD8 T Cells Defined by an IKZF2 + IL-7R - Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity by Naluyima, Prossy, Lal, Kerri G, Costanzo, Margaret C, Kijak, Gustavo H, Gonzalez, Veronica D, Blom, Kim, Eller, Leigh Anne, Creegan, Matthew, Hong, Ting, Kim, Dohoon, Quinn, Thomas C, Björkström, Niklas K, Ljunggren, Hans-Gustaf, Serwadda, David, Katabira, Elly T, Sewankambo, Nelson K, Gray, Ronald H, Baeten, Jared M, Michael, Nelson L, Wabwire-Mangen, Fred, Robb, Merlin L, Bolton, Diane L, Sandberg, Johan K, Eller, Michael A

“…HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may persist long after viral escape from TCR recognition. In this…”
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Preferential and persistent impact of acute HIV-1 infection on CD4⁺ iNKT cells in colonic mucosa by Paquin-Proulx, Dominic, Lal, Kerri G., Phuang-Ngern, Yuwadee, Creegan, Matthew, Tokarev, Andrey, Suhkumvittay, Suchada, Alrubayyi, Aljawharah, Kroon, Eugène, Pinyakorn, Suteeraporn, Slike, Bonnie M., Bolton, Diane L., Krebs, Shelly J., Eller, Leigh Anne, Sajjaweerawan, Chayada, Pagliuzza, Amélie, Chomont, Nicolas, Rerknimitr, Rungsun, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark S., Michael, Nelson L., Robb, Merlin L., Ananworanich, Jintanat, Sandberg, Johan K., Eller, Michael A., Schuetz, Alexandra

“…Acute HIV-1 infection (AHI) results in the widespread depletion of CD4⁺ T cells in peripheral blood and gut mucosal tissue. However, the impact on the…”
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OMIP‐046: Characterization of invariant T cell subset activation in humans by Lal, Kerri G., Leeansyah, Edwin, Sandberg, Johan K., Eller, Michael A.

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Peripheral blood MAIT cell response to enterotoxigenic E. coli strains H10407 and B7A after controlled human infection models (CHIMs) by Eller, Michael A., Lal, Kerri G, Kim, Dohoon, Vasan, Sandhya, Gramzinski, Robert A., Maciel, Milton

“…Abstract Mucosal associated invariant T (MAIT) cells are an unconventional T cell subset with a semi-invariant TCR that recognizes microbially-derived…”
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Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations by Dussupt, Vincent, Sankhala, Rajeshwer S., Mendez-Rivera, Letzibeth, Townsley, Samantha M., Schmidt, Fabian, Wieczorek, Lindsay, Lal, Kerri G., Donofrio, Gina C., Tran, Ursula, Jackson, Nathaniel D., Zaky, Weam I., Zemil, Michelle, Tritsch, Sarah R., Chen, Wei-Hung, Martinez, Elizabeth J., Ahmed, Aslaa, Choe, Misook, Chang, William C., Hajduczki, Agnes, Jian, Ningbo, Peterson, Caroline E., Rees, Phyllis A., Rutkowska, Magdalena, Slike, Bonnie M., Selverian, Christopher N., Swafford, Isabella, Teng, I-Ting, Thomas, Paul V., Zhou, Tongqing, Smith, Clayton J., Currier, Jeffrey R., Kwong, Peter D., Rolland, Morgane, Davidson, Edgar, Doranz, Benjamin J., Mores, Christopher N., Hatziioannou, Theodora, Reiley, William W., Bieniasz, Paul D., Paquin-Proulx, Dominic, Gromowski, Gregory D., Polonis, Victoria R., Michael, Nelson L., Modjarrad, Kayvon, Joyce, M. Gordon, Krebs, Shelly J.

“…Prevention of viral escape and increased coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic…”
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Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques by King, Hannah A. D., Joyce, M. Gordon, Lakhal-Naouar, Ines, Ahmed, Aslaa, Cincotta, Camila Macedo, Subra, Caroline, Peachman, Kristina K., Hack, Holly R., Chen, Rita E., Thomas, Paul V., Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Martinez, Elizabeth J., Peterson, Caroline E., Chang, William C., Choe, Misook, Smith, Clayton, Headley, Jarrett A., Elyard, Hanne A., Cook, Anthony, Anderson, Alexander, Wuertz, Kathryn McGuckin, Dong, Ming, Swafford, Isabella, Case, James B., Currier, Jeffrey R., Lal, Kerri G., Amare, Mihret F., Dussupt, Vincent, Molnar, Sebastian, Daye, Sharon P., Zeng, Xiankun, Barkei, Erica K., Alfson, Kendra, Staples, Hilary M., Carrion, Ricardo, Krebs, Shelly J., Paquin-Proulx, Dominic, Karasavvas, Nicos, Polonis, Victoria R., Jagodzinski, Linda L., Vasan, Sandhya, Scott, Paul T., Huang, Yaoxing, Nair, Manoj S., Ho, David D., de Val, Natalia, Diamond, Michael S., Lewisi, Mark G., Rao, Mangala, Matyas, Gary R., Gromowski, Gregory D., Peel, Sheila A., Michael, Nelson L., Modjarrad, Kayvon, Bolton, Diane L.

“…Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to…”
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Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques by Sankhala, Rajeshwer S., Lal, Kerri G., Jensen, Jaime L., Dussupt, Vincent, Mendez-Rivera, Letzibeth, Bai, Hongjun, Wieczorek, Lindsay, Mayer, Sandra V., Zemil, Michelle, Wagner, Danielle A., Townsley, Samantha M., Hajduczki, Agnes, Chang, William C., Chen, Wei-Hung, Donofrio, Gina C., Jian, Ningbo, King, Hannah A. D., Lorang, Cynthia G., Martinez, Elizabeth J., Rees, Phyllis A., Peterson, Caroline E., Schmidt, Fabian, Hart, Tricia J., Duso, Debra K., Kummer, Lawrence W., Casey, Sean P., Williams, Jazmean K., Kannan, Shruthi, Slike, Bonnie M., Smith, Lauren, Swafford, Isabella, Thomas, Paul V., Tran, Ursula, Currier, Jeffrey R., Bolton, Diane L., Davidson, Edgar, Doranz, Benjamin J., Hatziioannou, Theodora, Bieniasz, Paul D., Paquin-Proulx, Dominic, Reiley, William W., Rolland, Morgane, Sullivan, Nancy J., Vasan, Sandhya, Collins, Natalie D., Modjarrad, Kayvon, Gromowski, Gregory D., Polonis, Victoria R., Michael, Nelson L., Krebs, Shelly J., Joyce, M. Gordon

“…The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop…”
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The CD4^sup −^CD8^sup −^ MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8^sup +^ MAIT cell pool by Dias, Joana, Boulouis, Caroline, Gorin, Jean Baptiste, van den Biggelaar, Robin H G A, Lal, Kerri G, Gibbs, Anna, Loh, Liyen, Gulam, Muhammad Yaaseen, Sia, Wan Rong, Bari, Sudipto, Hwang, William Y K, Nixon, Douglas F, Nguyen, Son, Betts, Michael R, Buggert, Marcus, Eller, Michael A, Broliden, Kristina, Tjernlund, Annelie, Sandberg, Johan K, Leeansyah, Edwin

“…Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the MHC class…”
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Transcriptomic profiles of NK cell function indicate impaired responsiveness in chronic HIV-1 infection and enhanced functional activity post-vaccination by Costanzo, Margaret C, Kim, Dohoon, Creegan, Matthew, Lal, Kerri G, Ake, Julie, Currier, Jeffrey R, Streeck, Hendrik, Robb, Merlin L, Michael, Nelson L, Bolton, Diane L, Steers, Nicholas James Robert, Eller, Michael A.

“…Abstract Natural Killer (NK) cells limit viral replication by direct recognition and killing of infected cells, performing Fc mediated ADCC and releasing…”
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Terminally differentiated CD8 effector T cells have NK-like features and are potent mediators of HIV-specific ADCC by Lal, Kerri G, Naluyima, Prossy, Costanzo, Margaret C, Kijak, Gustavo H, Eller, Leigh Anne, Creegan, Matthew, Michael, Nelson L, Robb, Merlin L, Bolton, Diane L, Sandberg, Johan K, Eller, Michael A.

“…Abstract Chronic viral infection and persistent antigenic stimulation is associated with a rise of late-stage differentiated CD8 T cells including a unique…”
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Longitudinal Analysis of Peripheral and Colonic CD161 + CD4 + T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation by Lal, Kerri G, Phuang-Ngern, Yuwadee, Suhkumvittaya, Suchada, Leeansyah, Edwin, Alrubayyi, Aljawharah, Dias, Joana, Waickman, Adam, Kim, Dohoon, Kroon, Eugène, Pinyakorn, Suteeraporn, Eller, Leigh Anne, Maciel, Jr, Milton, Rerknimitr, Rungsun, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark S S, Nitayaphan, Sorachai, Ake, Julie A, Vasan, Sandhya, Robb, Merlin L, Ananworanich, Jintanat, Sandberg, Johan K, Schuetz, Alexandra, Eller, Michael A, Paquin-Proulx, Dominic

“…CD161 expression on CD4 T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18…”
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