Convenient Synthesis of Novel Quinazoline Congeners via Copper Catalyzed C-N/C-S Coupling and Their Biological Evaluation
A library of novel quinazoline scaffolds endowed with semicarbazide/oxadiazole thiol motif synthesized via an efficient and sustainable copper catalyzed C–N/C–S coupling is reported, making the presented methodology extremely valuable from economic and environmental point of view. Among the all synt...
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| Published in: | Journal of heterocyclic chemistry Vol. 53; no. 1; pp. 209 - 219 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken
Blackwell Publishing Ltd
01-01-2016
Wiley Subscription Services, Inc |
| Online Access: | Get full text |
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| Summary: | A library of novel quinazoline scaffolds endowed with semicarbazide/oxadiazole thiol motif synthesized via an efficient and sustainable copper catalyzed C–N/C–S coupling is reported, making the presented methodology extremely valuable from economic and environmental point of view. Among the all synthesized compounds screened for in vitro antibacterial, antifungal, and anti‐TB activity, 7b, 7c, 7f, 9b, 9c, 9i, and 9j showed excellent inhibitory effect on particular strain of bacteria, fungi, and M. tuberculosis H37Rv as well. All the newly synthesized derivatives were well characterized by their IR, 1H NMR, 13C NMR, mass spectroscopy as well as elemental analysis. |
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| Bibliography: | istex:D6B835EF7D0D20761E3C9B72974823F779B593D0 ark:/67375/WNG-7K0BWVNG-L ArticleID:JHET2404 |
| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.2404 |