Search Results - "Laksiri Gomes"

SARS-CoV-2 neutralizing antibodies in patients with varying severity of acute COVID-19 illness by Jeewandara, Chandima, Jayathilaka, Deshni, Gomes, Laksiri, Wijewickrama, Ananda, Narangoda, Eranga, Idampitiya, Damayanthi, Guruge, Dinuka, Wijayamuni, Ruwan, Manilgama, Suranga, Ogg, Graham S., Tan, Chee Wah, Wang, Lin-Fa, Malavige, Gathsaurie Neelika

“…In order to support vaccine development, and to aid convalescent plasma therapy, it would be important to understand the kinetics, timing and persistence of…”
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Similarities and differences between the ‘cytokine storms’ in acute dengue and COVID-19 by Dayarathna, Shashika, Jeewandara, Chandima, Gomes, Laksiri, Somathilaka, Gayasha, Jayathilaka, Deshni, Vimalachandran, Vimalahan, Wijewickrama, Ananda, Narangoda, Eranga, Idampitiya, Damayanthi, Ogg, Graham S., Malavige, Gathsaurie Neelika

“…Severe pneumonia and multiorgan dysfunction in COVID-19 and dengue haemorrhagic fever (DHF) are two diseases that can associate with an altered immune response…”
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Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection by Jayathilaka, Deshni, Gomes, Laksiri, Jeewandara, Chandima, Jayarathna, Geethal. S. Bandara, Herath, Dhanushka, Perera, Pathum Asela, Fernando, Samitha, Wijewickrama, Ananda, Hardman, Clare S., Ogg, Graham S., Malavige, Gathsaurie Neelika

“…The role of NS1-specific antibodies in the pathogenesis of dengue virus infection is poorly understood. Here we investigate the immunoglobulin responses of…”
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Comparison of different sequencing techniques for identification of SARS-CoV-2 variants of concern with multiplex real-time PCR by Ranasinghe, Diyanath, Jayadas, Tibutius Thanesh Pramanayagam, Jayathilaka, Deshni, Jeewandara, Chandima, Dissanayake, Osanda, Guruge, Dinuka, Ariyaratne, Dinuka, Gunasinghe, Dumni, Gomes, Laksiri, Wijesinghe, Ayesha, Wijayamuni, Ruwan, Malavige, Gathsaurie Neelika

“…As different SARS-CoV-2 variants emerge and with the continuous evolvement of sub lineages of the delta variant, it is crucial that all countries carry out…”
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Are viral loads in the febrile phase a predictive factor of dengue disease severity? by Dayarathna, Shashika, Kuruppu, Heshan, Silva, Tehani, Gomes, Laksiri, Shyamali, N. L. Ajantha, Jeewandara, Chandima, Ariyaratne, Dinuka, Ramu, Shyrar Tanussiya, Wijewickrama, Ananda, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…Abstract Background As many studies have shown conflicting results regarding the extent of viraemia and clinical disease severity, we sought to investigate if…”
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Urinary leukotrienes and histamine in patients with varying severity of acute dengue by Silva, Tehani, Jeewandara, Chandima, Gomes, Laksiri, Gangani, Chathurika, Mahapatuna, Sameera D, Pathmanathan, Thilagaraj, Wijewickrama, Ananda, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…Vascular leak is a hallmark of severe dengue, and high leukotriene levels have been observed in dengue mouse models, suggesting a role in disease pathogenesis…”
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Cellular and cytokine correlates of severe dengue infection by Malavige, Gathsaurie Neelika, Huang, Li-Chieh, Salimi, Maryam, Gomes, Laksiri, Jayaratne, S D, Ogg, Graham S

“…The occurrence of dengue haemorrhagic fever (DHF) is thought to result from a complex interplay between the virus, host genetics and host immune factors…”
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Development and validation of an assay for detection of Japanese encephalitis virus specific antibody responses by Pushpakumara, Pradeep Darshana, Jeewandara, Chandima, Gomes, Laksiri, Perera, Yashodha, Wijewickrama, Ananda, Malavige, Gathsaurie Neelika, Goonesekara, Charitha, Ansari, Aftab A, .

“…Introduction Although immune responses to the Japanese Encephalitis virus (JEV), and the dengue viruses (DENV) have a potential to modulate the immune…”
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Sensitivity and specificity of two WHO approved SARS-CoV2 antigen assays in detecting patients with SARS-CoV2 infection by Jeewandara, Chandima, Guruge, Dinuka, Pushpakumara, Pradeep Darshana, Madhusanka, Deshan, Jayadas, Tibutius Thanesh, Chaturanga, Indika Prasad, Aberathna, Inoka Sepali, Danasekara, Saubhagya, Pathmanathan, Thilagaraj, Jayathilaka, Deshni, Somathilaka, Gayasha, Kuruppu, Heshan, Gomes, Laksiri, Gunasekara, Vitjith, Wijayamuni, Ruwan, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…SARS-CoV-2 rapid antigen (Ag) detection kits are widely used in addition to quantitative reverse transcription PCR PCR (RT-qPCR), as they are cheaper with a…”
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Quantification of dengue virus specific T cell responses and correlation with viral load and clinical disease severity in acute dengue infection by Wijeratne, Dulharie T, Fernando, Samitha, Gomes, Laksiri, Jeewandara, Chandima, Ginneliya, Anushka, Samarasekara, Supun, Wijewickrama, Ananda, Hardman, Clare S, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…In order to understand the role of dengue virus (DENV) specific T cell responses that associate with protection, we studied their frequency and phenotype in…”
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Adipokine levels and their association with clinical disease severity in patients with dengue by Kuruppu, Heshan, Wickramanayake, W. P Rivindu H, Jeewandara, Chandima, Peranantharajah, Deneshan, Colambage, H. S, Perera, Lahiru, Gomes, Laksiri, Wijewickrama, Ananda, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…Adipokines have not been studied in acute dengue, despite their emerging role in inducing and regulating inflammation. Therefore, we sought to identify…”
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Sphingosine 1-phosphate in acute dengue infection by Gomes, Laksiri, Fernando, Samitha, Fernando, Randika Heshan, Wickramasinghe, Nilanka, Shyamali, Narangoda Liyanage Ajantha, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…Vascular leak is the hallmark of severe dengue infections and leads to complications such as shock and multi-organ failure. Although many mediators have been…”
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Aedes larval bionomics and implications for dengue control in the paradigmatic Jaffna peninsula, northern Sri Lanka by Surendran, Sinnathamby N, Jayadas, Tibutius T P, Thiruchenthooran, Vaikunthavasan, Raveendran, Selvarajah, Tharsan, Annathurai, Santhirasegaram, Sharanga, Sivabalakrishnan, Kokila, Karunakaran, Suthakar, Ponnaiah, Bharathy, Gomes, Laksiri, Malavige, Gathsaurie N, Ramasamy, Ranjan

“…The larval bionomics of Aedes across the Jaffna peninsula in northern Sri Lanka was investigated to obtain information needed for developing more effective…”
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Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial by Malavige, Gathsaurie Neelika, Jeewandara, Chandima, Wijewickrama, Ananda, Gunasinghe, Dumni, Mahapatuna, Sameera D, Gangani, Chathurika, Vimalachandran, Vimalahan, Jayarathna, Geethal, Perera, Yashoda, Wanigatunga, Chandanie, Dissanayake, Harsha, Prathapan, Shamini, Narangoda, Eranga, Idampitiya, Damayanthi, Gomes, Laksiri, Wickramanayake, Samurdhi, Sahabandu, Pramodth, Ogg, Graham S

“…Rupatadine was previously shown to reduce endothelial dysfunction in vitro, reduced vascular leak in dengue mouse models and to reduce the extent of pleural…”
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Phenotype and functionality of follicular helper T cells in patients with acute dengue infection by Wijesinghe, Ayesha, Gamage, Jayani, Goonewardena, Hemantha, Gomes, Laksiri, Jayathilaka, Deshni, Wijeratne, Dulharie T, de Alwis, Ruklanthi, Jeewandara, Chandima, Wijewickrama, Ananda, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease…”
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Change in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka by Jeewandara, Chandima, Gomes, Laksiri, Paranavitane, S A, Tantirimudalige, Mihiri, Panapitiya, Sumedha Sandaruwan, Jayewardene, Amitha, Fernando, Samitha, Fernando, R H, Prathapan, Shamini, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…Sri Lanka has been affected by epidemics of dengue infections for many decades and the incidence and severity of dengue infections have been rising each year…”
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Genomic and Epidemiological Analysis of SARS-CoV-2 Viruses in Sri Lanka by Jeewandara, Chandima, Jayathilaka, Deshni, Ranasinghe, Diyanath, Hsu, Nienyun Sharon, Ariyaratne, Dinuka, Jayadas, Tibutius Thanesh, Panambara Arachchige, Deshan Madhusanka, Lindsey, Benjamin B, Gomes, Laksiri, Parker, Matthew D, Wijewickrama, Ananda, Karunaratne, Malika, Ogg, Graham S, de Silva, Thushan I, Malavige, Gathsaurie Neelika

“…In order to understand the molecular epidemiology of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Sri Lanka, since March 2020, we carried…”
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Platelet activating factor contributes to vascular leak in acute dengue infection by Jeewandara, Chandima, Gomes, Laksiri, Wickramasinghe, N, Gutowska-Owsiak, Danuta, Waithe, Dominic, Paranavitane, S A, Shyamali, N L A, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…Although plasma leakage is the hallmark of severe dengue infections, the factors that cause increased vascular permeability have not been identified. As…”
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Suppression of virus specific immune responses by IL-10 in acute dengue infection by Malavige, Gathsaurie Neelika, Jeewandara, Chandima, Alles, K M Luckmaal, Salimi, Maryam, Gomes, Laksiri, Kamaladasa, Achala, Jayaratne, S D, Ogg, Graham Stuart

“…Elevated IL-10 has been shown to be associated with severe dengue infection (DI). We proceeded to investigate the role of IL-10 in the pathogenesis of acute…”
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Evaluation of the WHO revised criteria for classification of clinical disease severity in acute adult dengue infection by Jayaratne, S D, Atukorale, Vajini, Gomes, Laksiri, Chang, Thashi, Wijesinghe, Tharindu, Fernando, Sachie, Ogg, Graham S, Malavige, Gathsaurie Neelika

“…The WHO guidelines were revised recently to identify patients with severe dengue (SD) early. We proceeded to determine the usefulness of the warning signs in…”
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