Search Results - "Lakowski, Ted"

Bioinformatics driven discovery of small molecule compounds that modulate the FOXM1 and PPARA pathway activities in breast cancer by Huang, Shujun, Hu, Pingzhao, Lakowski, Ted M.

“…Our previous studies demonstrated that the FOXM1 pathway is upregulated and the PPARA pathway downregulated in breast cancer (BC), and especially in the triple…”
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Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4 by Lakowski, Ted M, Frankel, Adam

“…Protein arginine N-methyltransferases (PRMTs) methylate arginine residues within proteins using S-adenosyl-L-methionine (AdoMet) to form…”
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Predicting breast cancer drug response using a multiple-layer cell line drug response network model by Huang, Shujun, Hu, Pingzhao, Lakowski, Ted M

“…Background Predicting patient drug response based on a patient's molecular profile is one of the key goals of precision medicine in breast cancer (BC)…”
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Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS) by KhorshidAhmad, Tina, Acosta, Crystal, Cortes, Claudia, Lakowski, Ted M., Gangadaran, Surendiran, Namaka, Michael

“…Multiple sclerosis (MS) is a chronic progressive, neurological disease characterized by the targeted immune system-mediated destruction of central nervous…”
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Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes by Lillico, Ryan, Lawrence, Courtney K, Lakowski, Ted M

“…Mixed lineage leukemia results from chromosomal rearrangements of the gene mixed lineage leukemia (MLL). MLL-AF9 is one such rearrangement that recruits the…”
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Deep graph embedding for prioritizing synergistic anticancer drug combinations by Jiang, Peiran, Huang, Shujun, Fu, Zhenyuan, Sun, Zexuan, Lakowski, Ted M., Hu, Pingzhao

“…[Display omitted] Drug combinations are frequently used for the treatment of cancer patients in order to increase efficacy, decrease adverse side effects, or…”
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Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1 by Rowley, Michael J., Prout-Holm, Riley A., Liu, Rui Wen, Hendrickson-Rebizant, Thordur, Ige, Olufola O., Lakowski, Ted M., Frankel, Adam

“…Protein arginine N-methyltransferases are a family of epigenetic enzymes responsible for monomethylation or dimethylation of arginine residues on histones…”
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Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1 by Hendrickson-Rebizant, Thordur, Sudhakar, Sadhana R. N., Rowley, Michael J., Frankel, Adam, Davie, James R., Lakowski, Ted M.

“…Protein arginine N-methyltransferases (PRMT) are a family of S-adenosyl-l-methionine (SAM)-dependent enzymes that transfer methyl-groups to the ω-N of arginyl…”
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SARS‐CoV‐2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics by Beacon, Tasnim H., Su, Ruey‐Chyi, Lakowski, Ted M., Delcuve, Geneviève P., Davie, James R.

“…The SARS‐CoV‐2 makes its way into the cell via the ACE2 receptor and the proteolytic action of TMPRSS2. In response to the SARS‐CoV‐2 infection, the innate…”
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Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections by Zelenitsky, Sheryl A, Calic, Divna, Arora, Rakesh C, Grocott, Hilary P, Lakowski, Ted M, Lillico, Ryan, Ariano, Robert E

“…This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and…”
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A Kinetic Study of Human Protein Arginine N-Methyltransferase 6 Reveals a Distributive Mechanism by Lakowski, Ted M., Frankel, Adam

“…Human protein arginine N-methyltransferase 6 (PRMT6) transfers methyl groups from the co-substrate S-adenosyl-l-methionine to arginine residues within…”
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PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X by Vhuiyan, Mynol I, Pak, Magnolia L, Park, Margaret A, Thomas, Dylan, Lakowski, Ted M, Chalfant, Charles E, Frankel, Adam

“…Protein arginine N-methyltransferase 2 (PRMT2) functions in JAK-STAT and Wnt/β-catenin signalling pathways, serves as a nuclear receptor-dependent…”
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SARS‐CoV‐2 multifaceted interaction with human host. Part I: What we have learnt and done so far, and the still unknown realities by Delcuve, Geneviève P., Lakowski, Ted M., Su, Ruey‐Chyi, Beacon, Tasnim H., Davie, James R.

“…SARS‐CoV‐2, the causing agent of the ongoing COVID‐19 pandemic, is a beta‐coronavirus which has 80% genetic homology with SARS‐CoV, but displays increased…”
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HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases by Lillico, Ryan, Sobral, Marina Gomez, Stesco, Nicholas, Lakowski, Ted M.

“…Histone deacetylase (HDAC) inhibitors are cancer treatments that inhibit the removal of the epigenetic modification acetyllysine on histones, resulting in…”
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Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis by Lillico, Ryan, Zhou, Ting, Khorshid Ahmad, Tina, Stesco, Nicholas, Gozda, Kiana, Truong, Jessica, Kong, Jiming, Lakowski, Ted M, Namaka, Michael

“…Citrullination of arginine residues is a post-translational modification (PTM) found on myelin basic protein (MBP), which neutralizes MBPs positive charge, and…”
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Integrative Analysis Reveals Subtype-Specific Regulatory Determinants in Triple Negative Breast Cancer by Huang, Shujun, Xu, Wayne, Hu, Pingzhao, Lakowski, Ted M

“…Different breast cancer (BC) subtypes have unique gene expression patterns, but their regulatory mechanisms have yet to be fully elucidated. We hypothesized…”
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Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass by Calic, Divna, Ariano, Robert E, Arora, Rakesh C, Grocott, Hilary P, Lakowski, Ted M, Lillico, Ryan, Zelenitsky, Sheryl A

“…Although clinical practice guidelines recommend standard cefazolin antimicrobial prophylaxis (AP) dosing for cardiac surgery, limited data exist as to whether…”
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Bioinformatic Analyses of Broad H3K79me2 Domains in Different Leukemia Cell Line Data Sets by Sharma, Prerna, Sattarifard, Hedieh, Fatemiyan, Narges, Lakowski, Ted M, Davie, James R

“…A subset of expressed genes is associated with a broad H3K4me3 (histone H3 trimethylated at lysine 4) domain that extends throughout the gene body. Genes…”
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Simultaneous quantification of reparixin and paclitaxel in plasma and urine using ultra performance liquid chromatography-tandem mass spectroscopy (UHPLC–MS/MS): Application to a preclinical pharmacokinetic study in rats by Malhi, Sarandeep, Stesco, Nicholas, Alrushaid, Samaa, Lakowski, Ted M., Davies, Neal M., Gu, Xiaochen

“…A liquid chromatography-tandem mass spectroscopy (LC–MS/MS) assay was developed and validated to simultaneously quantify anticancer drugs reparixin and…”
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Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids by Novaes, Júlia T, Lillico, Ryan, Sayre, Casey L, Nagabushnam, Kalyanam, Majeed, Muhammed, Chen, Yufei, Ho, Emmanuel A, Oliveira, Ana Luísa de P, Martinez, Stephanie E, Alrushaid, Samaa, Davies, Neal M, Lakowski, Ted M

“…Tetrahydrocurcumin (THC), curcumin and calebin-A are curcuminoids found in turmeric ( ). Curcuminoids have been established to have a variety of…”
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