Search Results - "Lakovits, Karin"

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology by Gawish, Riem, Starkl, Philipp, Pimenov, Lisabeth, Hladik, Anastasiya, Lakovits, Karin, Oberndorfer, Felicitas, Cronin, Shane Jf, Ohradanova-Repic, Anna, Wirnsberger, Gerald, Agerer, Benedikt, Endler, Lukas, Capraz, Tümay, Perthold, Jan W, Cikes, Domagoj, Koglgruber, Rubina, Hagelkruys, Astrid, Montserrat, Nuria, Mirazimi, Ali, Boon, Louis, Stockinger, Hannes, Bergthaler, Andreas, Oostenbrink, Chris, Penninger, Josef M, Knapp, Sylvia

“…Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated…”
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First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment by Saluzzo, Simona, Gorki, Anna-Dorothea, Rana, Batika M.J., Martins, Rui, Scanlon, Seth, Starkl, Philipp, Lakovits, Karin, Hladik, Anastasiya, Korosec, Ana, Sharif, Omar, Warszawska, Joanna M., Jolin, Helen, Mesteri, Ildiko, McKenzie, Andrew N.J., Knapp, Sylvia

“…From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and…”
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Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages by Sharif, Omar, Brunner, Julia Stefanie, Korosec, Ana, Martins, Rui, Jais, Alexander, Snijder, Berend, Vogel, Andrea, Caldera, Michael, Hladik, Anastasiya, Lakovits, Karin, Saluzzo, Simona, Boehm, Benedikta, Gorki, Anna-Dorothea, Mesteri, Ildiko, Lindroos-Christensen, Josefine, Tillmann, Katharina, Stoiber, Dagmar, Menche, Jörg, Schabbauer, Gernot, Bilban, Martin, Superti-Furga, Giulio, Esterbauer, Harald, Knapp, Sylvia

“…Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering…”
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Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling by Zahalka, Sophie, Starkl, Philipp, Watzenboeck, Martin L., Farhat, Asma, Radhouani, Mariem, Deckert, Florian, Hladik, Anastasiya, Lakovits, Karin, Oberndorfer, Felicitas, Lassnig, Caroline, Strobl, Birgit, Klavins, Kristaps, Matsushita, Mai, Sanin, David E., Grzes, Katarzyna M., Pearce, Edward J., Gorki, Anna-Dorothea, Knapp, Sylvia

“…Environmental microbial triggers shape the development and functionality of the immune system. Alveolar macrophages (AMs), tissue-resident macrophages of the…”
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A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4 by Gawish, Riem, Maier, Barbara, Obermayer, Georg, Watzenboeck, Martin L, Gorki, Anna-Dorothea, Quattrone, Federica, Farhat, Asma, Lakovits, Karin, Hladik, Anastasiya, Korosec, Ana, Alimohammadi, Arman, Mesteri, Ildiko, Oberndorfer, Felicitas, Oakley, Fiona, Brain, John, Boon, Louis, Lang, Irene, Binder, Christoph J, Knapp, Sylvia

“…Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options…”
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Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner by Watzenboeck, Martin L, Drobits, Barbara, Zahalka, Sophie, Gorki, Anna-Dorothea, Farhat, Asma, Quattrone, Federica, Hladik, Anastasiya, Lakovits, Karin, Richard, Gabriel M, Lederer, Therese, Strobl, Birgit, Versteeg, Gijs A, Boon, Louis, Starkl, Philipp, Knapp, Sylvia

“…Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron…”
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The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial phagocytosis during pneumococcal pneumonia by Sharif, Omar, Matt, Ulrich, Saluzzo, Simona, Lakovits, Karin, Haslinger, Isabella, Furtner, Tanja, Doninger, Bianca, Knapp, Sylvia

“…CD36 is a scavenger receptor that exhibits pleiotropic functions, including adhesion to thrombospondin, inhibition of angiogenesis, transport of long-chain…”
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Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice by Maier, Barbara B., Hladik, Anastasiya, Lakovits, Karin, Korosec, Ana, Martins, Rui, Kral, Julia B., Mesteri, Ildiko, Strobl, Birgit, Müller, Mathias, Kalinke, Ulrich, Merad, Miriam, Knapp, Sylvia

“…Protecting the integrity of the lung epithelial barrier is essential to ensure respiration and proper oxygenation in patients suffering from various types of…”
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The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia by Sharif, Omar, Gawish, Riem, Warszawska, Joanna M, Martins, Rui, Lakovits, Karin, Hladik, Anastasiya, Doninger, Bianca, Brunner, Julia, Korosec, Ana, Schwarzenbacher, Roland E, Berg, Tiina, Kralovics, Robert, Colinge, Jacques, Mesteri, Ildiko, Gilfillan, Susan, Salmaggi, Andrea, Verschoor, Admar, Colonna, Marco, Knapp, Sylvia

“…Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2…”
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Triggering receptor expressed on myeloid cells‐2 fine‐tunes inflammatory responses in murine Gram‐negative sepsis by Gawish, Riem, Martins, Rui, Böhm, Benedikta, Wimberger, Terje, Sharif, Omar, Lakovits, Karin, Schmidt, Mariane, Knapp, Sylvia

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Murine Ex Vivo Cultured Alveolar Macrophages Provide a Novel Tool to Study Tissue-Resident Macrophage Behavior and Function by Gorki, Anna-Dorothea, Symmank, Dörte, Zahalka, Sophie, Lakovits, Karin, Hladik, Anastasiya, Langer, Brigitte, Maurer, Barbara, Sexl, Veronika, Kain, Renate, Knapp, Sylvia

“…Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models…”
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Triggering receptor expressed on myeloid cells‐2 fine‐tunes inflammatory responses in murine Gram‐negative sepsis by Gawish, Riem, Martins, Rui, Böhm, Benedikta, Wimberger, Terje, Sharif, Omar, Lakovits, Karin, Schmidt, Mariane, Knapp, Sylvia

“…During infections, TLR‐mediated responses require tight regulation to allow for pathogen removal, while preventing overwhelming inflammation and…”
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IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus by Starkl, Philipp, Watzenboeck, Martin L., Popov, Lauren M., Zahalka, Sophie, Hladik, Anastasiya, Lakovits, Karin, Radhouani, Mariem, Haschemi, Arvand, Marichal, Thomas, Reber, Laurent L., Gaudenzio, Nicolas, Sibilano, Riccardo, Stulik, Lukas, Fontaine, Frédéric, Mueller, André C., Amieva, Manuel R., Galli, Stephen J., Knapp, Sylvia

“…Allergies are considered to represent mal-directed type 2 immune responses against mostly innocuous exogenous compounds. Immunoglobulin E (IgE) antibodies are…”
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IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus by Starkl, Philipp, Watzenboeck, Martin L., Popov, Lauren M., Zahalka, Sophie, Hladik, Anastasiya, Lakovits, Karin, Radhouani, Mariem, Haschemi, Arvand, Marichal, Thomas, Reber, Laurent L., Gaudenzio, Nicolas, Sibilano, Riccardo, Stulik, Lukas, Fontaine, Frédéric, Mueller, André C., Amieva, Manuel R., Galli, Stephen J., Knapp, Sylvia

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Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions by Martins, Rui, Maier, Julia, Gorki, Anna-Dorothea, Huber, Kilian V M, Sharif, Omar, Starkl, Philipp, Saluzzo, Simona, Quattrone, Federica, Gawish, Riem, Lakovits, Karin, Aichinger, Michael C, Radic-Sarikas, Branka, Lardeau, Charles-Hugues, Hladik, Anastasiya, Korosec, Ana, Brown, Markus, Vaahtomeri, Kari, Duggan, Michelle, Kerjaschki, Dontscho, Esterbauer, Harald, Colinge, Jacques, Eisenbarth, Stephanie C, Decker, Thomas, Bennett, Keiryn L, Kubicek, Stefan, Sixt, Michael, Superti-Furga, Giulio, Knapp, Sylvia

“…Knapp and colleagues show that elevated heme levels following hemolysis impair the control of bacterial proliferation by inhibiting phagocytosis and migration…”
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Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes by Warszawska, Joanna M, Gawish, Riem, Sharif, Omar, Sigel, Stefanie, Doninger, Bianca, Lakovits, Karin, Mesteri, Ildiko, Nairz, Manfred, Boon, Louis, Spiel, Alexander, Fuhrmann, Valentin, Strobl, Birgit, Müller, Mathias, Schenk, Peter, Weiss, Günter, Knapp, Sylvia

“…Macrophages play a key role in responding to pathogens and initiate an inflammatory response to combat microbe multiplication. Deactivation of macrophages…”
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Multi-omics profiling predicts allograft function after lung transplantation by Watzenboeck, Martin L, Gorki, Anna-Dorothea, Quattrone, Federica, Gawish, Riem, Schwarz, Stefan, Lambers, Christopher, Jaksch, Peter, Lakovits, Karin, Zahalka, Sophie, Rahimi, Nina, Starkl, Philipp, Symmank, Dörte, Artner, Tyler, Pattaroni, Céline, Fortelny, Nikolaus, Klavins, Kristaps, Frommlet, Florian, Marsland, Benjamin J, Hoetzenecker, Konrad, Widder, Stefanie, Knapp, Sylvia

“…Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears the highest mortality rate among all solid…”
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SLC20A1 at the Interface between Macrophages and Red Blood Cells by Quattrone, Federica, Gawish, Riem, Martins, Rui, Gorki, Anna-Dorothea, Watzenboeck, Martin, Hladik, Anastasiya, Lakovits, Karin, Rebsamen, Manuele, Girardi, Enrico, Superti-Furga, Giulio, Knapp, Sylvia

“…Red blood cells (RBCs) comprise 84% of our body's cells and have the essential function of transporting oxygen from the lungs to all organs. The daily…”
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IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus by Starkl, Philipp, Watzenboeck, Martin L, Popov, Lauren M, Zahalka, Sophie, Hladik, Anastasiya, Lakovits, Karin, Radhouani, Mariem, Haschemi, Arvand, Marichal, Thomas, Reber, Laurent L, Gaudenzio, Nicolas, Sibilano, Riccardo, Stulik, Lukas, Fontaine, Frédéric, Mueller, André C, Amieva, Manuel R, Galli, Stephen J, Knapp, Sylvia

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The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis by Kosack, Lindsay, Gawish, Riem, Lercher, Alexander, Vilagos, Bojan, Hladik, Anastasiya, Lakovits, Karin, Bhattacharya, Anannya, Schliehe, Christopher, Mesteri, Ildiko, Knapp, Sylvia, Bergthaler, Andreas

“…Lipid metabolism is increasingly being appreciated to affect immunoregulation, inflammation and pathology. In this study we found that mice infected with…”
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