Search Results - "Lakkakorpi, P."

Real-world registry-based study on apremilast use in psoriasis and psoriatic arthritis in Finland by Koskivirta, I, Ruotsalainen, J, Kurki, S, Lakkakorpi, P, Salminen-Mankonen, H, Pirilä, L, Harvima, R, Palomäki, A

“…This study assessed the position of apremilast in the treatment pathway of psoriasis (PsO) and psoriatic arthritis (PsA) in Finnish clinical practice, compared…”
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Integrins and signaling in osteoclast function by Duong, Le T., Lakkakorpi, Päivi, Nakamura, Ichiro, Rodan, Gideon A.

“…Integrins are heterodimeric adhesion receptors that mediate cell–matrix and cell–cell interactions. Osteoclasts highly express the αvβ3 integrin, which binds…”
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PYK2 Autophosphorylation, but Not Kinase Activity, Is Necessary for Adhesion-induced Association with c-Src, Osteoclast Spreading, and Bone Resorption by Lakkakorpi, Parvi T, Bett, Andrew J, Lipfert, Lorraine, Rodan, Gideon A, Duong, Le T

“…Proline-rich tyrosine kinase 2 (PYK2) is the main adhesion-induced kinase in bone-resorbing osteoclasts. Previous studies have shown that ligation of α v β 3…”
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Evidence for the Presence of a Proton Pump of the Vacuolar H+- ATPase Type in the Ruffled Borders of Osteoclasts by Väänänen, H. K., E.-K. Karhukorpi, Sundquist, K., Wallmark, B., Roininen, I., Hentunen, T., Tuukkanen, J., Lakkakorpi, P.

“…Microsomal membrane vesicles prepared either from chicken medullary bone or isolated osteoclasts were shown to have ATP-dependent H+-transport activity. This…”
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Inhibition of Osteoclast Function by Adenovirus Expressing Antisense Protein-tyrosine Kinase 2 by Duong, Le T., Nakamura, Ichiro, Lakkakorpi, Päivi T., Lipfert, Lorraine, Bett, Andrew J., Rodan, Gideon A.

“…Osteoclast activation is initiated by adhesion to bone, cytoskeletal rearrangement, formation of the sealing zone, and formation of the polarized ruffled…”
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Vitronectin Receptor Has a Role in Bone Resorption but Does Not Mediate Tight Sealing Zone Attachment of Osteoclasts to the Bone Surface by Lakkakorpi, P. T., Horton, M. A., Helfrich, M. H., E.-K. Karhukorpi, Väänänen, H. K.

“…During bone resorption, osteoclasts form a tight attachment, the sealing zone, around resorption lacunae. Vitronectin receptor has previously been shown to be…”
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Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro by Lakkakorpi, Paivi T., Väänänen, Kalervo H.

“…Resorption and migration phases alternate in the life of the osteoclast. We have previously described a specific microfilament structure at the attachment…”
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Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone by Nakamura, I, Pilkington, M F, Lakkakorpi, P T, Lipfert, L, Sims, S M, Dixon, S J, Rodan, G A, Duong, L T

“…The alpha(v)beta(3) integrin is abundantly expressed in osteoclasts and has been implicated in the regulation of osteoclast function, especially in cell…”
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Phosphatidylinositol 3-Kinase Association with the Osteoclast Cytoskeleton, and Its Involvement in Osteoclast Attachment and Spreading by Lakkakorpi, P.T., Wesolowski, G., Zimolo, Z., Rodan, G.A., Rodan, S.B.

“…Osteoclast activation involves attachment to the mineralized bone matrix and reorganization of the cytoskeleton, leading to polarization of the cell. Signaling…”
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β1 integrins and osteoclast function : Involvement in collagen recognition and bone resorption by HELFRICH, M. H, NESBITT, S. A, LAKKAKORPI, P. T, BARNES, M. J, BODARY, S. C, SHANKAR, G, MASON, W. T, MENDRICK, D. L, VÄÄNÄNEN, H. K, HORTON, M. A

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Spatial organization of microfilaments and vitronectin receptor, αvβ3, in osteoclasts : a study using confocal laser scanning microscopy by LAKKAKORPI, P. T, HELFRICH, M. H, HORTON, M. A, VÄÄNÄNEN, H. K

“…The primary function of the osteoclast is that of the major cell mediating bone resorption. They are actively migrating cells but during resorption they…”
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Cytoskeletal changes in osteoclasts during the resorption cycle by Lakkakorpi, Päivi T., Väänänen, H. Kalervo

“…Osteoclasts are large, multinucleated cells which change their shape and polarity according to their resorptive activity. At least in vitro, nonresorbing…”
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Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells by RUOHOLA, Johanna K, VIITANEN, Tiina P, VALVE, Eeva M, SEPPÄNEN, Jani A, LOPONEN, Niina T, KESKITALO, Jaakko J, LAKKAKORPI, Päivi T, HÄRKÖNEN, Pirkko L

“…Fibroblast growth factor 8 (FGF-8) is a secreted heparin-binding protein, which has mitogenic and transforming activity. Increased expression of FGF-8 has been…”
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Calcitonin, prostaglandin E2, and dibutyryl cyclic adenosine 3',5'- monophosphate disperse the specific microfilament structure in resorbing osteoclasts by Lakkakorpi, PT, Vaananen, HK

“…Bone resorbing osteoclasts form a specific microfilament structure at the attachment area, in which vinculin and talin appear as a double-circle structure and…”
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Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy by Lakkakorpi, P T, Helfrich, M H, Horton, M A, Väänänen, H K

“…The primary function of the osteoclast is that of the major cell mediating bone resorption. They are actively migrating cells but during resorption they…”
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Isolation and Characterization of Highly Enriched, Prefusion Mouse Osteoclastic Cells by Wesolowski, Gregg, Duong, Le T., Lakkakorpi, Päivi T., Nagy, Rose M., Tezuka, Ken-Ichi, Tanaka, Hirofumi, Rodan, Gideon A., Rodan, Sevgi B.

“…This study describes the isolation and characterization of highly enriched mammalian osteoclast precursors, released by the "disintegrin" echistatin, from an…”
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Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts by Lakkakorpi, P T, Nakamura, I, Young, M, Lipfert, L, Rodan, G A, Duong, L T

“…The non-receptor tyrosine kinase Src was shown to be essential for osteoclast function in vivo. We have previously reported that engagement of…”
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Inhibition of bone resorption in vitro by a peptide containing the cadherin cell adhesion recognition sequence HAV is due to prevention of sealing zone formation by Ilvesaro, J M, Lakkakorpi, P T, Väänänen, H K

“…Cadherins are transmembrane glycoproteins usually mediating homophilic calcium-dependent cell-cell adhesion in a variety of cells and species. All classical…”
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Effects of Recombinant Human Osteogenic Protein-1 on the Differentiation of Osteoclast-Like Cells and Bone Resorption by Hentunen, T.A., Lakkakorpi, P.T., Tuukkanen, J., Lehenkari, P.P., Sampath, T.K., Vaananen, H.K.

“…Recombinant human OP-1 stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) significantly and in a…”
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Inhibition of bone resorption by a monoclonal antibody that reacts with a 150 kD membrane protein in chicken osteoclasts by Hentunen, Teuvo A., Lakkakorpi, Päivi T., Rautiala, Timo, Väänanen, H. Kalervo

“…Bone resorption is a multistep process that includes the maturation of osteoclast precursors, the special attachment of fully differentiated osteoclasts to…”
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