Search Results - "Lakio, Satu"

Comparison between twin-screw and high-shear granulation - The effect of filler and active pharmaceutical ingredient on the granule and tablet properties by Kyttä, Kaisa M., Lakio, Satu, Wikström, Håkan, Sulemanji, Anisa, Fransson, Magnus, Ketolainen, Jarkko, Tajarobi, Pirjo

“…The aim of the study was to compare continuous twin-screw granulation (TSG) with batch-wise high-shear granulation (HSG). Two different formulations containing…”
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Continuous manufacturing of extended release tablets via powder mixing and direct compression by Ervasti, Tuomas, Simonaho, Simo-Pekka, Ketolainen, Jarkko, Forsberg, Peter, Fransson, Magnus, Wikström, Håkan, Folestad, Staffan, Lakio, Satu, Tajarobi, Pirjo, Abrahmsén-Alami, Susanna

“…[Display omitted] The aim of the current work was to explore continuous dry powder mixing and direct compression for manufacturing of extended release (ER)…”
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The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process by Ervasti, Tuomas, Niinikoski, Hannes, Mäki-Lohiluoma, Eero, Leppinen, Heidi, Ketolainen, Jarkko, Korhonen, Ossi, Lakio, Satu

“…Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a…”
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Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery by Lakio, Satu, Morton, David A.V., Ralph, Anna P., Lambert, Pete

“…In this study a carrier-free dry powder inhalation (DPI) containing L-arginine (ARG) was developed. As such, it is proposed that ARG could be used for…”
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Dead mass in continuous blending by Kauppinen, Ari, Karhu, Hannu, Lakio, Satu

“…Continuous manufacturing is an emerging technology in secondary pharmaceutical manufacturing of oral solid dosage forms such as tablets. Continuous blending is…”
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Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing by Mathiyalagan, Rathna, Sjöholm, Erica, Manandhar, Sajana, Lakio, Satu, Rosenholm, Jessica M., Kaasalainen, Martti, Wang, Xiaoju, Sandler, Niklas

“…Semi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized…”
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Corrigendum to “Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing” European Journal of Pharmaceutical Sciences 188 (2023) 106497 by Mathiyalagan, Rathna, Sjöholm, Erica, Manandhar, Sajana, Lakio, Satu, Rosenholm, Jessica M., Kaasalainen, Martti, Wang, Xiaoju, Sandler, Niklas

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The role of physico-chemical and bulk characteristics of co-spray dried l-leucine and polyvinylpyrrolidone on glidant and binder properties in interactive mixtures by Mangal, Sharad, Meiser, Felix, Lakio, Satu, Morton, David, Larson, Ian

“…[Display omitted] In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive…”
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Small is Powerful: Demonstration of the Impact of Nanoformed Piroxicam in a Controlled Clinical Study by Lakio, Satu, Smith, David J., Andrade, Goncalo, Sandler, Niklas, Evans, Philip, McDermott, John, Roe, Chris, Hӕggström, Edward

“…Purpose New solutions are needed to enable the efficient use of poorly water-soluble drugs. Therefore, we aimed to demonstrate that decreasing particle size…”
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A systematic study of the impact of changes of roller compactor equipment on granule and tablet properties by Haeffler, Gunnar, Schmidt, Leonard, Lakio, Satu, Reynolds, Gavin, Ödman, Jonas, Tajarobi, Pirjo

“…Typical industrial development of roller compaction processes include changes in scale from laboratory to pilot and then further to production scale and also…”
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The effect of mechanical dry coating with magnesium stearate on flowability and compactibility of plastically deforming microcrystalline cellulose powders by Koskela, Jaana, Morton, David A.V., Stewart, Peter J., Juppo, Anne M., Lakio, Satu

“…[Display omitted] Mechanofusion is a dry coating method that can be used to improve the flowability of cohesive powder by coating host particles with a…”
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Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective by Hsiao, Wen-Kai, Hörmann, Theresa R., Toson, Peter, Paudel, Amrit, Ghiotti, Patrizia, Stauffer, Fanny, Bauer, Finn, Lakio, Satu, Behrend, Olaf, Maurer, Reto, Holman, James, Khinast, Johannes

“…•Continuous processing represents new challenges in pharmaceutical material science.•Critique of key process steps such as feeding on product quality has…”
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Provoking an end-to-end continuous direct compression line with raw materials prone to segregation by Lakio, Satu, Ervasti, Tuomas, Tajarobi, Pirjo, Wikström, Håkan, Fransson, Magnus, Karttunen, Anssi-Pekka, Ketolainen, Jarkko, Folestad, Staffan, Abrahmsén-Alami, Susanna, Korhonen, Ossi

“…Continuous manufacturing of solid oral dosage forms is promising for increasing the efficiency and quality of pharmaceutical production and products. In this…”
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Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression by Qu, Li, Stewart, Peter J, Hapgood, Karen P, Lakio, Satu, Morton, David A V, Zhou, Qi Tony

“…This study aims at testing the feasibility of a single-step coating process to produce a powder formulation of active and inactive ingredients for direct…”
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A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules by Laske, Stephan, Paudel, Amrit, Scheibelhofer, Otto

“…Pharmaceutical solid oral dosage product manufacturing is a well-established, yet revolutionizing area. To this end, process analytical technology (PAT)…”
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Fast Tablet Tensile Strength Prediction Based on Non-Invasive Analytics by Halenius, Anna, Lakio, Satu, Antikainen, Osmo, Hatara, Juha, Yliruusi, Jouko

“…In this paper, linkages between tablet surface roughness, tablet compression forces, material properties, and the tensile strength of tablets were studied…”
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Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures by Mangal, Sharad, Lakio, Satu, Gengenbach, Thomas, Larson, Ian, Morton, David A.V.

“…[Display omitted] In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets…”
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Water-mediated solid-state transformation of a polymorphic drug during aqueous-based drug-layer coating of pellets by Lust, Andres, Lakio, Satu, Vintsevits, Julia, Kozlova, Jekaterina, Veski, Peep, Heinämäki, Jyrki, Kogermann, Karin

“…Anhydrous piroxicam form I and piroxicam monohydrate were stable during an aqueous drug layer coating of pellets but a solid state transformation of amorphous…”
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Determination of segregation tendency of granules using surface imaging by Lakio, Satu, Hatara, Juha, Tervakangas, Hanna, Sandler, Niklas

“…In this study, powder surface imaging was utilized in evaluation of particle size-related segregation behavior of granules during vibration and tableting…”
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Achieving a robust drug release from extended release tablets using an integrated continuous mixing and direct compression line by Lakio, Satu, Tajarobi, Pirjo, Wikström, Håkan, Fransson, Magnus, Arnehed, Johan, Ervasti, Tuomas, Simonaho, Simo-Pekka, Ketolainen, Jarkko, Folestad, Staffan, Abrahmsén-Alami, Susanna

“…[Display omitted] In the present work the viability of integrated continuous mixing and compression processes for manufacturing of extended release (ER) matrix…”
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