Search Results - "Lakin, Steven"
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MEGARes 2.0: a database for classification of antimicrobial drug, biocide and metal resistance determinants in metagenomic sequence data
Published in Nucleic acids research (08-01-2020)“…Abstract Antimicrobial resistance (AMR) is a threat to global public health and the identification of genetic determinants of AMR is a critical component to…”
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MEGARes: an antimicrobial resistance database for high throughput sequencing
Published in Nucleic acids research (04-01-2017)“…Antimicrobial resistance has become an imminent concern for public health. As methods for detection and characterization of antimicrobial resistance move from…”
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Horizontal Gene Transfer and Acquired Antibiotic Resistance in Salmonella enterica Serovar Heidelberg following In Vitro Incubation in Broiler Ceca
Published in Applied and environmental microbiology (15-11-2019)“…The chicken gastrointestinal tract harbors microorganisms that play a role in the health and disease status of the host. The cecum is the part of the gut that…”
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West African Anopheles gambiae mosquitoes harbor a taxonomically diverse virome including new insect-specific flaviviruses, mononegaviruses, and totiviruses
Published in Virology (New York, N.Y.) (01-11-2016)“…Abstract Anopheles gambiae are a major vector of malaria in sub-Saharan Africa. Viruses that naturally infect these mosquitoes may impact their physiology and…”
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Domestic pigs are susceptible to experimental infection with non-human primate-derived Reston virus without the need for adaptation
Published in Scientific reports (06-01-2024)“…Domestic pigs are a critical component of the food supply and one of the most commonly raised production animals. Pork consumption has driven the…”
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Characterization of the Microbial Resistome in Conventional and “Raised Without Antibiotics” Beef and Dairy Production Systems
Published in Frontiers in microbiology (04-09-2019)“…Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance…”
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Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent
Published in BMC microbiology (27-08-2019)“…Comparative knowledge of microbiomes and resistomes across environmental interfaces between animal production systems and urban settings is lacking. In this…”
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Rapid Detection and Quick Characterization of African Swine Fever Virus Using the VolTRAX Automated Library Preparation Platform
Published in Viruses (01-05-2024)“…African swine fever virus (ASFV) is the causative agent of a severe and highly contagious viral disease affecting domestic and wild swine. The current ASFV…”
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Demographic and histopathologic features of dogs with abnormally high concentrations of hepatic copper
Published in Journal of veterinary internal medicine (01-11-2022)“…Background Copper associated hepatopathy (CAH) has become an important and prevalent disease since the 1990's, coincidental with changes in copper (Cu) content…”
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Litter Commensal Bacteria Can Limit the Horizontal Gene Transfer of Antimicrobial Resistance to Salmonella in Chickens
Published in Applied and environmental microbiology (10-05-2022)“…Fostering a "balanced" gut microbiome through the administration of beneficial microbes that can competitively exclude pathogens has gained a lot of attention…”
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Investigating Effects of Tulathromycin Metaphylaxis on the Fecal Resistome and Microbiome of Commercial Feedlot Cattle Early in the Feeding Period
Published in Frontiers in microbiology (30-07-2018)“…The objective was to examine effects of treating commercial beef feedlot cattle with therapeutic doses of tulathromycin, a macrolide antimicrobial drug, on…”
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Experimental Infection of Bundibugyo Virus in Domestic Swine Leads to Viral Shedding with Evidence of Intraspecies Transmission
Published in Transboundary and emerging diseases (09-01-2024)“…The Ebolavirus genus contains several of the deadliest zoonotic viruses known. One of these, Bundibugyo virus (BDBV), has been the causative agent of two…”
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Effects of a Saccharomyces cerevisiae fermentation product on liver abscesses, fecal microbiome, and resistome in feedlot cattle raised without antibiotics
Published in Scientific reports (22-02-2019)“…Liver abscesses in feedlot cattle form secondary to high concentrate feeds and rumen acidosis. Antimicrobial drugs are commonly included in cattle feed for…”
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Direct RNA Sequencing of Foot-and-mouth Disease Virus Genome Using a Flongle on MinION
Published in Bio-protocol (20-06-2024)“…Aphthovirus, within the family Picornaviridae. Early detection and characterization of FMDV strains are key factors to control new outbreaks and prevent the…”
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Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022
Published in Emerging infectious diseases (01-04-2024)“…In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo…”
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Enrichment allows identification of diverse, rare elements in metagenomic resistome-virulome sequencing
Published in Microbiome (17-10-2017)“…Shotgun metagenomic sequencing is increasingly utilized as a tool to evaluate ecological-level dynamics of antimicrobial resistance and virulence, in…”
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Coding-complete genome sequences of rabbit hemorrhagic disease virus type 2 detected in 2023 in Washington State indicate a divergent incursion into the United States
Published in Microbiology resource announcements (11-04-2024)“…Three rabbit hemorrhagic disease virus type 2 (RHDV2) coding-complete genome sequences were obtained from domestic and wild rabbits in Washington State in June…”
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Whole Genome Sequencing Shows that African Swine Fever Virus Genotype IX Is Still Circulating in Domestic Pigs in All Regions of Uganda
Published in Pathogens (Basel) (01-07-2023)“…Blood samples were collected from pigs at six abattoirs in the Kampala, Uganda metropolitan area from May 2021 through June 2022, and tested for African swine…”
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Horizontal Gene Transfer Is the Main Driver of Antimicrobial Resistance in Broiler Chicks Infected with Salmonella enterica Serovar Heidelberg
Published in mSystems (31-08-2021)“…The overuse and misuse of antibiotics in clinical settings and in food production have been linked to the increased prevalence and spread of antimicrobial…”
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Hierarchical Hidden Markov models enable accurate and diverse detection of antimicrobial resistance sequences
Published in Communications biology (06-08-2019)“…The characterization of antimicrobial resistance genes from high-throughput sequencing data has become foundational in public health research and regulation…”
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