Search Results - "Lakhashe, Samir"

Mucosal AIDS virus transmission is enhanced by antiviral IgG isolated early in infection by Marasini, Bishal, Vyas, Hemant K., Lakhashe, Samir K., Hariraju, Dinesh, Akhtar, Akil, Ratcliffe, Sarah J., Ruprecht, Ruth M.

“…Antibody-dependent enhancement (ADE) affects host-virus dynamics in fundamentally different ways: i) enhancement of initial virus acquisition, and/or ii)…”
Get full text

An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV by Watkins, Jennifer D, Siddappa, Nagadenahalli B, Lakhashe, Samir K, Humbert, Michael, Sholukh, Anton, Hemashettar, Girish, Wong, Yin Ling, Yoon, John K, Wang, Wendy, Novembre, Francis J, Villinger, Francois, Ibegbu, Chris, Patel, Kalpana, Corti, Davide, Agatic, Gloria, Vanzetta, Fabrizia, Bianchi, Siro, Heeney, Jonathan L, Sallusto, Federica, Lanzavecchia, Antonio, Ruprecht, Ruth M

“…Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question…”
Get full text

Anti-HIV IgM protects against mucosal SHIV transmission by Gong, Siqi, Tomusange, Khamis, Kulkarni, Viraj, Adeniji, Opeyemi S, Lakhashe, Samir K, Hariraju, Dinesh, Strickland, Amanda, PLAKE, Elizabeth, Frost, Patrice A, Ratcliffe, Sarah J, WANG, Liping, Lafer, Eileen M, Ruprecht, Ruth M

“…OBJECTIVE:Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to…”
Get full text

Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission by WATKINS, Jennifer D, SHOLUKH, Anton M, VILLINGER, Francois, CORTI, Davide, RUPRECHT, Ruth M, MUKHTAR, Muhammad M, SIDDAPPA, Nagadenahalli B, LAKHASHE, Samir K, KIM, Mikyung, REINHERZ, Ellis L, GUPTA, Sandeep, FORTHAL, Donald N, SATTENTAU, Quentin J

“…Although passive immunization with anti-HIV-1 Env IgG1 neutralizing monoclonal antibodies (nmAbs) prevented simian-human immunodeficiency virus (SHIV)…”
Get full text

Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques by Hsu, Denise C, Sunyakumthorn, Piyanate, Wegner, Matthew, Schuetz, Alexandra, Silsorn, Decha, Estes, Jacob D, Deleage, Claire, Tomusange, Khamis, Lakhashe, Samir K, Ruprecht, Ruth M, Lombardini, Eric, Im-Erbsin, Rawiwan, Kuncharin, Yanin, Phuang-Ngern, Yuwadee, Inthawong, Dutsadee, Chuenarom, Weerawan, Burke, Robin, Robb, Merlin L, Ndhlovu, Lishomwa C, Ananworanich, Jintanat, Valcour, Victor, O'Connell, Robert J, Spudich, Serena, Michael, Nelson L, Vasan, Sandhya

“…Studies utilizing highly pathogenic simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) have largely focused on the…”
Get full text

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge by Sholukh, Anton M, Watkins, Jennifer D, Vyas, Hemant K, Gupta, Sandeep, Lakhashe, Samir K, Thorat, Swati, Zhou, Mingkui, Hemashettar, Girish, Bachler, Barbara C, Forthal, Donald N, Villinger, Francois, Sattentau, Quentin J, Weiss, Robin A, Agatic, Gloria, Corti, Davide, Lanzavecchia, Antonio, Heeney, Jonathan L, Ruprecht, Ruth M

“…Highlights • We used IgG1 and dimeric IgA2 versions of the V3-loop specific mAb HGN194. • HGN194 IgG1 given iv at a low dose to monkeys: 0% protection from…”
Get full text

Cooperation Between Systemic IgG1 and Mucosal Dimeric IgA2 Monoclonal Anti-HIV Env Antibodies: Passive Immunization Protects Indian Rhesus Macaques Against Mucosal SHIV Challenges by Gong, Siqi, Lakhashe, Samir K, Hariraju, Dinesh, Scinto, Hanna, Lanzavecchia, Antonio, Cameroni, Elisabetta, Corti, Davide, Ratcliffe, Sarah J, Rogers, Kenneth A, Xiao, Peng, Fontenot, Jane, Villinger, François, Ruprecht, Ruth M

“…Understanding the interplay between systemic and mucosal anti-HIV antibodies can provide important insights to develop new prevention strategies. We used…”
Get full text

Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges by Lakhashe, Samir K, Amacker, Mario, Hariraju, Dinesh, Vyas, Hemant K, Morrison, Kyle S, Weiner, Joshua A, Ackerman, Margaret E, Roy, Vicky, Alter, Galit, Ferrari, Guido, Montefiori, David C, Tomaras, Georgia D, Sawant, Sheetal, Yates, Nicole L, Gast, Chris, Fleury, Sylvain, Ruprecht, Ruth M

“…A virosomal vaccine inducing systemic/mucosal anti-HIV-1 gp41 IgG/IgA had previously protected Chinese-origin rhesus macaques (RMs) against vaginal SHIV…”
Get full text

Novel Biopanning Strategy To Identify Epitopes Associated with Vaccine Protection by Bachler, Barbara C, Humbert, Michael, Palikuqi, Brisa, Siddappa, Nagadenahalli B, Lakhashe, Samir K, Rasmussen, Robert A, Ruprecht, Ruth M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Antibody-mediated immune exclusion of HIV by Ruprecht, Ruth M, Lakhashe, Samir K

“…PURPOSE OF REVIEWAlthough approximately 90% of all HIV transmissions in humans occur through mucosal contact, the induction of mucosal anti-HIV immune…”
Get full text

Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge by Malherbe, Delphine C, Mendy, Jason, Vang, Lo, Barnette, Philip T, Reed, Jason, Lakhashe, Samir K, Owuor, Joshua, Gach, Johannes S, Legasse, Alfred W, Axthelm, Michael K, LaBranche, Celia C, Montefiori, David, Forthal, Donald N, Park, Byung, Wilson, James M, McLinden, James H, Xiang, Jinhua, Stapleton, Jack T, Sacha, Jonah B, Haynes, Barton F, Liao, Hua-Xin, Ruprecht, Ruth M, Smith, Jonathan, Gurwith, Marc, Haigwood, Nancy L, Alexander, Jeff

“…HIV vaccine development is focused on designing immunogens and delivery methods that elicit protective immunity. We evaluated a combination of adenovirus (Ad)…”
Get full text

Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge by Malherbe, Delphine C, Vang, Lo, Mendy, Jason, Barnette, Philip T, Spencer, David A, Reed, Jason, Kareko, Bettie W, Sather, D Noah, Pandey, Shilpi, Wibmer, Constantinos K, Robins, Harlan, Fuller, Deborah H, Park, Byung, Lakhashe, Samir K, Wilson, James M, Axthelm, Michael K, Ruprecht, Ruth M, Moore, Penny L, Sacha, Jonah B, Hessell, Ann J, Alexander, Jeff, Haigwood, Nancy L

“…Designing immunogens and improving delivery methods eliciting protective immunity is a paramount goal of HIV vaccine development. A comparative vaccine…”
Get full text

Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants by Zhou, Mingkui, Humbert, Michael, Mukhtar, Muhammad M, Scinto, Hanna B, Vyas, Hemant K, Lakhashe, Samir K, Byrareddy, Siddappa N, Maurer, Gregor, Thorat, Swati, Owuor, Joshua, Lai, Zhao, Chen, Yidong, Griffiths, Anthony, Chenine, Agnès-Laurence, Gumber, Sanjeev, Villinger, François, Montefiori, David, Ruprecht, Ruth M

“…Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and…”
Get full text

Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection by Lakhashe, Samir K, Wang, Wendy, Siddappa, Nagadenahalli B, Hemashettar, Girish, Polacino, Patricia, Hu, Shiu-Lok, Villinger, François, Else, James G, Novembre, Francis J, Yoon, John K, Lee, Sandra J, Montefiori, David C, Ruprecht, Ruth M, Rasmussen, Robert A

“…A safe, efficacious vaccine is required to stop the AIDS pandemic. Disappointing results from the STEP trial implied a need to include humoral anti-HIV-1…”
Get full text

A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly by Sciaranghella, Gaia, Lakhashe, Samir K, Ayash-Rashkovsky, Mila, Mirshahidi, Saied, Siddappa, Nagadenahalli B, Novembre, Francis J, Velu, Vijayakumar, Amara, Rama Rao, Zhou, Chenghui, Li, Sufen, Li, Zhongxia, Frankel, Fred R, Ruprecht, Ruth M

“…Abstract Listeria monocytogenes (Lm) is known to induce strong cellular immune responses. We constructed a live-attenuated Lm vector, Lmdd-BdopSIVgag , which…”
Get full text

Lymphocytes upregulate CD36 in adipose tissue and liver by Couturier, Jacob, Nuotio-Antar, Alli M, Agarwal, Neeti, Wilkerson, Gregory K, Saha, Pradip, Kulkarni, Viraj, Lakhashe, Samir K, Esquivel, Juan, Nehete, Pramod N, Ruprecht, Ruth M, Sastry, K Jagannadha, Meyer, Jennifer M, Hill, Lori R, Lake, Jordan E, Balasubramanyam, Ashok, Lewis, Dorothy E

“…CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is…”
Get full text

Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose by Sholukh, Anton M, Byrareddy, Siddappa N, Shanmuganathan, Vivekanandan, Hemashettar, Girish, Lakhashe, Samir K, Rasmussen, Robert A, Watkins, Jennifer D, Vyas, Hemant K, Thorat, Swati, Brandstoetter, Tania, Mukhtar, Muhammad M, Yoon, John K, Novembre, Francis J, Villinger, Francois, Landucci, Gary, Forthal, Donald N, Ratcliffe, Sarah, Tuero, Iskra, Robert-Guroff, Marjorie, Polonis, Victoria R, Bilska, Miroslawa, Montefiori, David C, Johnson, Welkin E, Ertl, Hildegund C, Ruprecht, Ruth M

“…A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be…”
Get full text

R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models by Siddappa, Nagadenahalli B, Watkins, Jennifer D, Wassermann, Klemens J, Song, Ruijiang, Wang, Wendy, Kramer, Victor G, Lakhashe, Samir, Santosuosso, Michael, Poznansky, Mark C, Novembre, Francis J, Villinger, François, Else, James G, Montefiori, David C, Rasmussen, Robert A, Ruprecht, Ruth M

“…HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but…”
Get full text

Live-virus exposure of vaccine-protected macaques alters the anti-HIV-1 antibody repertoire in the absence of viremia by Bachler, Barbara C, Humbert, Michael, Lakhashe, Samir K, Rasmussen, Robert A, Ruprecht, Ruth M

“…We addressed the question whether live-virus challenges could alter vaccine-induced antibody (Ab) responses in vaccinated rhesus macaques (RMs) that completely…”
Get full text

No acquisition: A new ambition for HIV vaccine development? by Lakhashe, Samir K, Silvestri, Guido, Ruprecht, Ruth M

“…► RV144 trial data and recent non-human primate studies suggest that HIV-1 acquisition may be preventable by vaccination. ► Induction of virus-specific humoral…”
Get full text