Search Results - "Lakey, Jonathan Rt"

Cryopreservation: An Overview of Principles and Cell-Specific Considerations by Whaley, David, Damyar, Kimia, Witek, Rafal P., Mendoza, Alan, Alexander, Michael, Lakey, Jonathan RT

“…The origins of low-temperature tissue storage research date back to the late 1800s. Over half a century later, osmotic stress was revealed to be a main…”
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Comparison of Islet Characterization from Use of Standard Crude Collagenase to GMP-Grade Collagenase Enzyme Blends in Preweaned Porcine Islet Isolations by Corrales, Nicole, Park, Soomin, Lau, Hien, Xu, Ivana, Luong, Colleen, Rodriguez, Samuel, Mönch, Johanna, Alexander, Michael, Lakey, Jonathan RT

“…For the advancement of porcine xenotransplantation for clinical use in type 1 diabetes mellitus, the concerns of a sustainable and safe digestion enzyme blend…”
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Preferences of Type 1 Diabetic Patients on Devices for Islet Transplantation by Mohammadi, M. Rezaa, Dehkordi-Vakil, Farideh, Ricks-Oddie, Joni, Mansfield, Robert, Kashmiri, Himala, Daniels, Mark, Zhao, Weian, Lakey, Jonathan RT

“…Transplantation of pancreatic islets within a biomaterial device is currently under investigation in clinical trials for the treatment of patients with type 1…”
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Cryopreserved Alginate-Encapsulated Islets Can Restore Euglycemia in a Diabetic Animal Model Better than Cryopreserved Non-encapsulated Islets by Kojayan, Greg G, Flores, Antonio, Li, Shiri, Alexander, Michael, Lakey, Jonathan RT

“…Islet transplantation has been shown to restore normoglycemia clinically. One of the current limitations to the widespread clinical use of islet…”
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Improved cryopreservation yield of pancreatic islets using combination of lower dose permeable cryoprotective agents by Kojayan, Greg, Whaley, David, Alexander, Michael, Rodriguez, Samuel, Lee, Sarah, Lakey, Jonathan RT

“…Islet transplantation has been shown to restore normoglycemia in animal models and for type 1 diabetic patients in clinical trials. One method of storing…”
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Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets by Lau, Hien, Li, Shiri, Corrales, Nicole, Rodriguez, Samuel, Mohammadi, Mohammadreza, Alexander, Michael, de Vos, Paul, Lakey, Jonathan Rt

“…Pre-weaned porcine islets (PPIs) represent an unlimited source for islet transplantation but are functionally immature. We previously showed that necrostatin-1…”
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Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice by Gurlin, Rachel E, Keating, Mark T, Li, Shiri, Lakey, Jonathan RT, de Feraudy, Sébastien, Shergill, Bhupinder S, Botvinick, Elliot L

“…Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood…”
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Human islet mass, morphology, and survival after cryopreservation using the Edmonton protocol by Miranda, Priya M, Mohan, Viswanathan, Ganthimathy, Sekhar, Anjana, Ranjit M, Gunasekaran, S, Thiagarajan, Venkatachalam, Churchill, Thomas A, Kin, Tatsuya, Shapiro, AM James, Lakey, Jonathan RT

“…The aim of this study was to assess recovery, cell death, and cell composition of post-thaw cultured human islets. Cryopreserved islets were provided by the…”
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Encapsulated islet transplantation: strategies and clinical trials by Buder, Brian, Alexander, Michael, Krishnan, Rahul, Chapman, David W, Lakey, Jonathan Rt

“…Encapsulation of tissue has been an area of intense research with a myriad number of therapeutic applications as diverse as cancer, tissue regeneration, and…”
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P12.06: Effect of Supplementing Taurine to the Developed Lowtemperature Islet Preservation Solution by Park 1, Jae-Kyung, Kwak, Kyungmin, Shim, Joohyun, Ko, Nayoung, Kim, Hyoung-joo, Lee, Yongjin, Kim, Jun-Hyeong, Kim, Eui-Hyun, Kang, Pulip, Lakey, Jonathan RT, Kim, Hyunil, Choi, Kimyung

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P17.03: Quadruple KO Porcine Adult Pancreatic Islet Induced Longterm Xenograft Survival in Diabetic Mice by Kwak, Kyungmin, Park, Jae-kyung, Shim, Joohyun, Ko, Nayoung, Kim, Hyoung-Joo, Lee, Yongjin, Kim, Jun-Hyeong, Kim, Eui-Hyun, Kang, Pulip, Lakey, Jonathan RT, Kim, Hyunil, Choi, Kimyung

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Inclusion of extracellular matrix molecules and necrostatin-1 in the intracapsular environment of alginate-based microcapsules synergistically protects pancreatic β cells against cytokine-induced inflammatory stress by Qin, Tian, Hu, Shuxian, Smink, Alexandra M., de Haan, Bart J., Silva-Lagos, Luis A., Lakey, Jonathan R.T., de Vos, Paul

“…Immunoisolation of pancreatic islets in alginate-based microcapsules is a promising approach for grafting of islets in absence of immunosuppression. However,…”
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International Trial of the Edmonton Protocol for Islet Transplantation by Shapiro, A.M. James, Ricordi, Camillo, Hering, Bernhard J, Auchincloss, Hugh, Lindblad, Robert, Robertson, R. Paul, Secchi, Antonio, Brendel, Mathias D, Berney, Thierry, Brennan, Daniel C, Cagliero, Enrico, Alejandro, Rodolfo, Ryan, Edmond A, DiMercurio, Barbara, Morel, Philippe, Polonsky, Kenneth S, Reems, Jo-Anna, Bretzel, Reinhard G, Bertuzzi, Federico, Froud, Tatiana, Kandaswamy, Raja, Sutherland, David E.R, Eisenbarth, George, Segal, Miriam, Preiksaitis, Jutta, Korbutt, Gregory S, Barton, Franca B, Viviano, Lisa, Seyfert-Margolis, Vicki, Bluestone, Jeffrey, Lakey, Jonathan R.T

“…Islet transplantation is an evolving therapy that may be considered for patients with type 1 diabetes mellitus complicated by severe hypoglycemia or labile…”
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Five-Year Follow-Up After Clinical Islet Transplantation by RYAN, Edmond A, PATY, Breay W, SENIOR, Peter A, BIGAM, David, ALFADHLI, Eman, KNETEMAN, Norman M, LAKEY, Jonathan R. T, SHAPIRO, A. M

“…Five-Year Follow-Up After Clinical Islet Transplantation Edmond A. Ryan 1 , Breay W. Paty 1 , Peter A. Senior 1 , David Bigam 2 , Eman Alfadhli 1 , Norman M…”
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The current situation in human pancreatic islet transplantation: problems and prospects by Kobayashi, Naoya, Okitsu, Teru, Lakey, Jonathan R T, Tanaka, Noriaki

“…In 2000, seven cases of pancreatic islet transplantation were documented by the researchers at the University of Alberta (Edmonton, Canada). The…”
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The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture by Lau, Hien, Corrales, Nicole, Rodriguez, Samuel, Park, Soomin, Mohammadi, Mohammadreza, Li, Shiri, Alexander, Michael, Lakey, Jonathan R.T.

“…Background Necrostatin‐1 (Nec‐1) supplementation to tissue culture media on day 3 has recently been shown to augment the insulin content, endocrine cellular…”
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Non-Invasive Monitoring of Oxygen Tension and Oxygen Transport Inside Subcutaneous Devices After H2S Treatment by Najdahmadi, Avid, Smink, Alexandra M., de Vos, Paul, Lakey, Jonathan R.T., Botvinick, Elliot

“…Medical devices for cell therapy can be improved through prevascularization. In this work we study the vascularization of a porous polymer device, previously…”
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Juvenile Porcine Islets Can Restore Euglycemia in Diabetic Athymic Nude Mice After Xenotransplantation by Krishnan, Rahul, Buder, Brian, Alexander, Michael, Foster, Clarence E, Lakey, Jonathan RT

“…BACKGROUNDPorcine islet xenotransplantation has been demonstrated in many animal studies to cure experimentally induced diabetes. However, several issues…”
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Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen by Shapiro, A.M. James, Lakey, Jonathan R.T, Ryan, Edmond A, Korbutt, Gregory S, Toth, Ellen, Warnock, Garth L, Kneteman, Norman M, Rajotte, Ray V

“…Islet transplantation has been investigated as a treatment for type 1 diabetes mellitus in selected patients with inadequate glucose control despite insulin…”
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Consistency and Scalability of Young Porcine Islet Isolations by Lakey, Jonathan RT, Lamb, Morgan, Alexander, Michael, Stahul, Remick, Zhou, Tianyi, Foster, Clarence E

“…Xenotransplantation of porcine pancreatic islets continues to make research advances to clinical trials. Our efforts have been focused on a model of using…”
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