Search Results - "Lakey, Jonathan R.T"

Five-Year Follow-Up After Clinical Islet Transplantation by RYAN, Edmond A, PATY, Breay W, SENIOR, Peter A, BIGAM, David, ALFADHLI, Eman, KNETEMAN, Norman M, LAKEY, Jonathan R. T, SHAPIRO, A. M

“…Five-Year Follow-Up After Clinical Islet Transplantation Edmond A. Ryan 1 , Breay W. Paty 1 , Peter A. Senior 1 , David Bigam 2 , Eman Alfadhli 1 , Norman M…”
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Hepatitis C virus replication in mice with chimeric human livers by Kneteman, Norman M, Mercer, David F, Schiller, Daniel E, Elliott, John F, Douglas, Donna N, Hao, Chunhai, Rinfret, Aline, Addison, William R, Fischer, Karl P, Churchill, Thomas A, Lakey, Jonathan R.T, Tyrrell, David L.J

“…Lack of a small animal model of the human hepatitis C virus (HCV) has impeded development of antiviral therapies against this epidemic infection. By…”
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Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol by RYAN, Edmond A, LAKEY, Jonathan R. T, WARNOCK, Garth L, LARSEN, Ingrid, SHAPIRO, A. M, RAJOTTE, Ray V, KORBUTT, Gregory S, KIN, Tatsuya, IMES, Sharleen, RABINOVITCH, Alex, ELLIOTT, John F, BIGAM, David, KNETEMAN, Norman M

“…Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol Edmond A. Ryan 1 , Jonathan R.T. Lakey 2 , Ray V. Rajotte 2 ,…”
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High-Throughput Screening of Encapsulated Islets Using Wide-Field Lens-Free On-Chip Imaging by Zhang, Yibo, Alexander, Michael, Yang, Sam, Bian, Yinxu, Botvinick, Elliot, Lakey, Jonathan R.T, Ozcan, Aydogan

“…Islet microencapsulation is a promising solution to diabetes treatment, but its quality control based on manual microscopic inspection is extremely…”
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A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function by BEATTIE, Gillian M, MONTGOMERY, Anthony M. P, LOPEZ, Ana D, ERGENG HAO, PEREZ, Brandon, JUST, Margaret L, LAKEY, Jonathan R. T, HART, Marquis E, HAYEK, Alberto

“…A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function Gillian M. Beattie 1 , Anthony M.P. Montgomery 1 , Ana D. Lopez 1 , Ergeng…”
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Prevalence of Hepatic Steatosis After Islet Transplantation and Its Relation to Graft Function by BHARGAVA, Ravi, SENIOR, Peter A, ACKERMAN, Thomas E, RYAN, Edmond A, PATY, Breay W, LAKEY, Jonathan R. T, SHAPIRO, A. M

“…Prevalence of Hepatic Steatosis After Islet Transplantation and Its Relation to Graft Function Ravi Bhargava 1 , Peter A. Senior 2 , Thomas E. Ackerman 1 ,…”
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XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes by EMAMAULLEE, Juliet A, RAJOTTE, Ray V, LISTON, Peter, KORNELUK, Robert G, LAKEY, Jonathan R. T, SHAPWO, A. M, ELLIOTT, John F

“…XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes Juliet A. Emamaullee 1 2 , Ray…”
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Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin Independence by PATY, Breay W, RYAN, Edmond A, SHAPIRO, A. M, LAKEY, Jonathan R. T, ROBERTSON, R. Paul

“…Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin…”
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Decellularization reduces the immune response to aortic valve allografts in the rat by Meyer, Steven R., Nagendran, Jeevan, Desai, Leena S., Rayat, Gina R., Churchill, Thomas A., Anderson, Colin C., Rajotte, Ray V., Lakey, Jonathan R.T., Ross, David B.

“…Cryopreserved valve allografts used in congenital cardiac surgery are associated with a significant cellular and humoral immune response. This might be reduced…”
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Mathematical predictions of oxygen availability in micro‐ and macro‐encapsulated human and porcine pancreatic islets by Cao, Rui, Avgoustiniatos, Efstathios, Papas, Klearchos, Vos, Paul, Lakey, Jonathan R. T.

“…Optimal function of immunoisolated islets requires adequate supply of oxygen to metabolically active insulin producing beta‐cells. Using mathematical modeling,…”
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The Efficacy of a Prevascularized, Retrievable Poly(D,L,-lactide-co-ε-caprolactone) Subcutaneous Scaffold as Transplantation Site for Pancreatic Islets by Smink, Alexandra M, Li, Shiri, Hertsig, Don T, de Haan, Bart J, Schwab, Leendert, van Apeldoorn, Aart A, de Koning, Eelco, Faas, Marijke M, Lakey, Jonathan R.T, de Vos, Paul

“…BACKGROUNDThe liver as transplantation site for human pancreatic islets is a harsh microenvironment for islets and it lacks the ability to retrieve the graft…”
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International Trial of the Edmonton Protocol for Islet Transplantation by Shapiro, A.M. James, Ricordi, Camillo, Hering, Bernhard J, Auchincloss, Hugh, Lindblad, Robert, Robertson, R. Paul, Secchi, Antonio, Brendel, Mathias D, Berney, Thierry, Brennan, Daniel C, Cagliero, Enrico, Alejandro, Rodolfo, Ryan, Edmond A, DiMercurio, Barbara, Morel, Philippe, Polonsky, Kenneth S, Reems, Jo-Anna, Bretzel, Reinhard G, Bertuzzi, Federico, Froud, Tatiana, Kandaswamy, Raja, Sutherland, David E.R, Eisenbarth, George, Segal, Miriam, Preiksaitis, Jutta, Korbutt, Gregory S, Barton, Franca B, Viviano, Lisa, Seyfert-Margolis, Vicki, Bluestone, Jeffrey, Lakey, Jonathan R.T

“…Islet transplantation is an evolving therapy that may be considered for patients with type 1 diabetes mellitus complicated by severe hypoglycemia or labile…”
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Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide by GEISLER, John G, ZAWALICH, Walter, ZAWALICH, Kathleen, LAKEY, Jonathan R. T, STUKENBROK, Hans, MILICI, Anthony J, SOELLER, Walter C

“…Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide John G. Geisler 1 , Walter Zawalich 1 , Kathleen…”
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Immunological Challenges Facing Translation of Alginate Encapsulated Porcine Islet Xenotransplantation to Human Clinical Trials by Krishnan, Rahul, Ko, David, Foster, 3rd, Clarence E, Liu, Wendy, Smink, A M, de Haan, Bart, De Vos, Paul, Lakey, Jonathan R T

“…Transplantation of alginate-encapsulated islets has the potential to treat patients suffering from type I diabetes, a condition characterized by an autoimmune…”
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Pancreatic stellate cells support human pancreatic β-cell viability in vitro and enhance survival of immunoisolated human islets exposed to cytokines by Qin, Tian, Hu, Shuxian, Kong, Defu, Lakey, Jonathan R.T., de Vos, Paul

“…Pancreatic islet transplantation is proposed as a cure for type 1 diabetes mellitus (T1D). Despite its success in optimal regulation of glucose levels,…”
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Successful islet transplantation: continued insulin reserve provides long-term glycemic control by Ryan, Edmond A, Lakey, Jonathan R T, Paty, Breay W, Imes, Sharleen, Korbutt, Gregory S, Kneteman, Norman M, Bigam, David, Rajotte, Ray V, Shapiro, A M James

“…Clinical islet transplantation is gaining acceptance as a potential therapy, particularly for subjects who have labile diabetes or problems with hypoglycemic…”
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Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet‐transplantation enhances immediate post‐transplant islet graft function but not long‐term normoglycemia by Smink, Alexandra M., Li, Shiri, Swart, Daniël H., Hertsig, Don T., de Haan, Bart J., Kamps, Jan A. A. M., Schwab, Leendert, van Apeldoorn, Aart A., de Koning, Eelco, Faas, Marijke M., Lakey, Jonathan R. T., de Vos, Paul

“…The liver as transplantation site for pancreatic islets is associated with significant loss of islets, which can be prevented by grafting in a prevascularized,…”
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Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen by Shapiro, A.M. James, Lakey, Jonathan R.T, Ryan, Edmond A, Korbutt, Gregory S, Toth, Ellen, Warnock, Garth L, Kneteman, Norman M, Rajotte, Ray V

“…Islet transplantation has been investigated as a treatment for type 1 diabetes mellitus in selected patients with inadequate glucose control despite insulin…”
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Comparison of aortic valve allograft decellularization techniques in the rat by Meyer, Steven R., Chiu, Brian, Churchill, Thomas A., Zhu, Linfu, Lakey, Jonathan R.T., Ross, David B.

“…Rodent models have been essential to understanding the immune‐mediated failure of aortic valve allografts (AVAs). Decellularization has been proposed to reduce…”
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Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model by Krishnan, Rahul, Arora, Rajan P, Alexander, Michael, White, Sean M, Lamb, Morgan W, Foster, Clarence E, Choi, Bernard, Lakey, Jonathan R.T

“…Abstract Alginate encapsulation reduces the risk of transplant rejection by evading immune-mediated cell injury and rejection; however, poor vascular perfusion…”
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