Search Results - "Laken, Conny J."

Positron emission tomography/magnetic resonance imaging of the sacroiliac joints and spine to monitor effects of anti–tumor necrosis factor therapy in axial spondyloarthritis: comment on the article by Bruckmann et al by Jongh, Jerney, Zwezerijnen, Gerben J. C., Yaqub, Maqsood, Laken, Conny J.

Get full text

First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis by Verweij, Nicki J. F., Yaqub, Maqsood, Bruijnen, Stefan T. G., Pieplenbosch, S., ter Wee, Marieke M., Jansen, Gerrit, Chen, Qingshou, Low, Philip S., Windhorst, Albert D., Lammertsma, Adriaan A., Hoekstra, Otto S., Voskuyl, Alexandre E., van der Laken, Conny J.

“…Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic…”
Get full text

Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis by Khodadust, Fatemeh, Ezdoglian, Aiarpi, Steinz, Maarten M., van Beijnum, Judy R., Zwezerijnen, Gerben J. C., Jansen, Gerrit, Tas, Sander W., van der Laken, Conny J.

“…Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid arthritis (RA) from a very early stage of the disease onward and…”
Get full text

Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [ 11 C]DPA-713 Positron Emission Tomography by Yaqub, Maqsood, Verweij, Nicki J F, Pieplenbosch, Simone, Boellaard, Ronald, Lammertsma, Adriaan A, van der Laken, Conny J

“…Treatment for rheumatoid arthritis (RA) should be started as early as possible to prevent destruction of bone and cartilage in affected joints. A new…”
Get full text

Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition by van den Ende, Tom, Ezdoglian, Aiarpi, Baas, Lisanne M., Bakker, Joyce, Lougheed, Sinéad M., Harrasser, Micaela, Waasdorp, Cynthia, van Berge Henegouwen, Mark I., Hulshof, Maarten C.C.M., Haj Mohammad, Nadia, van Hillegersberg, Richard, Mook, Stella, van der Laken, Conny J., van Grieken, Nicole C.T., Derks, Sarah, Bijlsma, Maarten F., van Laarhoven, Hanneke W.M., de Gruijl, Tanja D.

“…The analysis of peripheral blood mononuclear cells (PBMCs) by flow cytometry holds promise as a platform for immune checkpoint inhibition (ICI) biomarker…”
Get full text

Three‐Year Clinical Outcome Following Baseline Magnetic Resonance Imaging in Anti–Citrullinated Protein Antibody–Positive Arthralgia Patients: An Exploratory Study by Gent, Yoony Y. J., ter Wee, Marieke M., Ahmadi, Nazanin, Kuijk, Cornelis, Voskuyl, Alexandre E., Laken, Conny J., Dowling, Cristina, de Stadt, Lotte A., Schaardenburg, Dirkjan

Get full text

In-vivo monitoring of anti-folate therapy in arthritic rats using [ 18 F]fluoro-PEG-folate and positron emission tomography by Chandrupatla, Durga M S H, Jansen, Gerrit, Vos, Ricardo, Verlaan, Mariska, Chen, Qingshou, Low, Philip S, Windhorst, Albert D, Lammertsma, Adriaan A, van der Laken, Conny J, Molthoff, Carla F M

“…Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is…”
Get full text

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects by Jiemy, William Febry, Heeringa, Peter, Kamps, Jan A.A.M., van der Laken, Conny J., Slart, Riemer H.J.A., Brouwer, Elisabeth

“…Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer,…”
Get full text

Presence of active MRI lesions in patients suspected of non-radiographic axial spondyloarthritis with high disease activity and chance at conversion after a 6-month follow-up period by Rusman, Tamara, John, Marie-Luise B., van der Weijden, Mignon A. C., Boden, Bouke J. H., van der Bijl, Carmella M. A., Bruijnen, Stefan T. G., van der Laken, Conny J., Nurmohamed, Mike T., van der Horst-Bruinsma, Irene E.

“…Objectives The primary aim is to evaluate signs of inflammation on MRI of sacroiliac joints (SIJ)/spine in inflammatory back pain (IBP) patients suspected of…”
Get full text

The value of joint ultrasonography in predicting arthritis in seropositive patients with arthralgia: a prospective cohort study by van Beers-Tas, Marian H, Blanken, Annelies B, Nielen, Mark M J, Turkstra, Franktien, van der Laken, Conny J, Meursinge Reynders, Marlies, van Schaardenburg, Dirkjan

“…The value of joint ultrasonography (US) in the prediction of clinical arthritis in individuals at risk of developing rheumatoid arthritis (RA) is still a point…”
Get full text

Should vascular wall 18F-FDG uptake be adjusted for the extent of atherosclerotic burden? by Lensen, Karel-Jan D. F., Voskuyl, Alexandre E., Comans, Emile F. I., van der Laken, Conny J., Boellaard, Ronald, Smulders, Yvo M.

“…Vascular wall 18 F-FDG uptake is often used as a surrogate marker of atherosclerotic plaque inflammation. A potential caveat is that vascular wall 18 F-FDG…”
Get full text

A novel 3D spheroid model of rheumatoid arthritis synovial tissue incorporating fibroblasts, endothelial cells, and macrophages by Philippon, Eva M L, van Rooijen, Lisanne J E, Khodadust, Fatemeh, van Hamburg, Jan Piet, van der Laken, Conny J, Tas, Sander W

“…Rheumatoid Arthritis (RA) is a progressive and systemic autoimmune disorder associated with chronic and destructive joint inflammation. The hallmarks of joint…”
Get full text

Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis by Steinz, Maarten M, Ezdoglian, Aiarpi, Khodadust, Fatemeh, Molthoff, Carla F M, Srinivasarao, Madduri, Low, Philip S, Zwezerijnen, Gerben J C, Yaqub, Maqsood, Beaino, Wissam, Windhorst, Albert D, Tas, Sander W, Jansen, Gerrit, van der Laken, Conny J

“…Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and therapy response monitoring of patients with autoimmune diseases,…”
Get full text

Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: Findings of a prospective pilot study by Gent, Yoony Y. J., Voskuyl, Alexandre E., Kloet, Reina W., van Schaardenburg, Dirkjan, Hoekstra, Otto S., Dijkmans, Ben A. C., Lammertsma, Adriaan A., van der Laken, Conny J.

“…Objective To conduct a prospective pilot study to determine whether macrophage targeting by 11C‐(R)‐PK11195 positron emission tomography (PET) can visualize…”
Get full text

IgA Immune Complexes Induce Osteoclast-Mediated Bone Resorption by Breedveld, Annelot C., van Gool, Melissa M. J., van Delft, Myrthe A. M., van der Laken, Conny J., de Vries, Teun J., Jansen, Ineke D. C., van Egmond, Marjolein

“…Objective Autoantibodies are detected in most patients with rheumatoid arthritis (RA) and can be of the IgM, IgG or IgA subclass. Correlations between IgA…”
Get full text

The type I interferon signature in leukocyte subsets from peripheral blood of patients with early arthritis: a major contribution by granulocytes by de Jong, Tamarah D, Lübbers, Joyce, Turk, Samina, Vosslamber, Saskia, Mantel, Elise, Bontkes, Hetty J, van der Laken, Conny J, Bijlsma, Johannes W, van Schaardenburg, Dirkjan, Verweij, Cornelis L

“…The type I interferon (IFN) signature in rheumatoid arthritis (RA) has shown clinical relevance in relation to disease onset and therapeutic response…”
Get full text

Effect of prednisone on type I interferon signature in rheumatoid arthritis: consequences for response prediction to rituximab by de Jong, Tamarah D, Vosslamber, Saskia, Blits, Marjolein, Wolbink, Gertjan, Nurmohamed, Mike T, van der Laken, Conny J, Jansen, Gerrit, Voskuyl, Alexandre E, Verweij, Cornelis L

“…Elevated type I interferon (IFN) response gene (IRG) expression has proven clinical relevance in predicting rituximab non-response in rheumatoid arthritis…”
Get full text

Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study by Gent, Yoony Y J, Ter Wee, Marieke M, Voskuyl, Alexandre E, den Uyl, Debby, Ahmadi, Nazanin, Dowling, Cristina, van Kuijk, Cornelis, Hoekstra, Otto S, Boers, Maarten, Lems, Willem F, van der Laken, Conny J

“…Residual subclinical synovitis can still be present in joints of rheumatoid arthritis (RA) patients despite clinical remission and has been linked to ongoing…”
Get full text

In Vivo Imaging of Inflammation and Infection 2019 by Roivainen, Anne, Li, Xiang-Guo, Ohrndorf, Sarah, van der Laken, Conny J.

“…The contents of this special issue cover from early phases of ligand design, chemistry development, and preclinical evaluations to clinical imaging protocols…”
Get full text

F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach by Bruijnen, Stefan T.G, Chandrupatla, Durga M.S.H, Giovanonni, Leonardo, Neri, Dario, Vugts, Danielle J, Huisman, Marc C, Hoekstra, Otto S, Musters, René J.P, Lammertsma, Adriaan A, van Dongen, Guus A.M.S, Jansen, Gerrit, Molthoff, Carla F.M, van der Laken, Conny J

“…Antibody fragment F8-mediated interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin…”
Get full text