Search Results - "Lake, Phil"

Influence of relative binding affinity on efficacy in a panel of anti-CD3 scFv immunotoxins by Hexham, J.Mark, Dudas, Debra, Hugo, Ron, Thompson, Jerry, King, Vicki, Dowling, Carol, Neville, David M, Digan, Mary Ellen, Lake, Phil

“…The in vitro cell killing potency of an immunotoxin reflects the aggregate of several independent biochemical properties. These include antigen binding…”
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A high-capacity alkaline phosphatase reporter system for the rapid analysis of specificity and relative affinity of peptides from phage-display libraries by Wright, Richard M., Dudas, Debra, Gavin, Brian, Dottavio, Diane, Hexham, J.Mark, Lake, Phil

“…We describe a novel reporter enzyme cassette system which enables the analysis of large numbers of linear and cyclic peptides in terms of their binding to a…”
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Obligatory role of gamma interferon in T cell-replacing factor-dependent, antigen-specific murine B cell responses by BRUNSWICK, M, LAKE, P

“…The role of gamma interferon (IFN-gamma) in T cell-replacing factor (TRF) activity for antigen-specific plaque-forming cell (PFC) responses in vitro was…”
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Binding Epitope of Somatostatin Defined by Phage-Displayed Peptide Libraries by Wright, Richard M, Gram, Hermann, Vattay, Anthony, Byrne, Susan, Lake, Phil, Dottavio, Diane

“…We have developed a versatile phagemid system to display peptides on the surface of M13 bacteriophage at a copy number which approaches monovalency. In this…”
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Optimization of the anti-(human CD3) immunotoxin DT389-scFv(UCHT1) N-terminal sequence to yield a homogeneous protein by Hexham, J. Mark, King, Vicki, Dudas, Debra, Graff, Patrick, Mahnke, Marion, Wang, Y. Karen, Goetschy, Jean-Francois, Plattner, David, Zurini, Mauro, Bitsch, Francis, Lake, Phil, Digan, Mary Ellen

“…The production and regulatory approval processes for biopharmaceuticals require detailed characterization of potential products. Therapeutic proteins should…”
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Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin by Lamb, Jonathan R, Eckels, David D, Lake, Phil, Woody, James N, Green, Nicola

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SB -restricted presentation of influenza and herpes simplex virus antigens to human T-Iymphocyte clones by Eckels, David D, Lake, Phil, Lamb, Jonathan R, Johnson, Armead H, Shaw, Stephen, Woody, James N, Hartzman, Robert J

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Antibody response induced in vitro to the cell-surface alloantigen Thy-1 by LAKE, PHIL

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In vitro studies of transplantation immunity by Lake, Phil

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Functional interactions of human and murine lymphoid cells. I. Analysis of primary and secondary responses by Brunswick, M, Lake, P

“…In this study human T-cell responses against murine alloantigens were analyzed. The results show that optimal primary responses are obtained from peripheral…”
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Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T cell subsets by Lake, P, Clark, E A, Khorshidi, M, Sunshine, G H

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Recognition and genetic control of helper determinants for cell surface antigen Thy-1 by LAKE, PHIL, DOUGLAS, TOMMY C

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T-cell replacing factor activity of recombinant-derived interleukin-2 requires gamma-interferon by Lake, P, Brunswick, M

“…In this study we show that recombinant-derived human interleukin-2 (rIL-2) has potent T-cell replacing activity in antigen-driven murine antibody responses of…”
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Antigen-specific human T-lymphocyte clones. Genetic restriction of influenza virus-specific responses to HLA-D region genes by Eckels, D D, Lamb, J R, Lake, P, Woody, J N, Johnson, A H, Hartzman, R J

“…Human T lymphocytes, primed in vitro to influenza virus, were cloned by limiting dilution and expanded using medium containing interleukin 2 and feeder cells…”
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Inhibition of T cell proliferation by antibodies to synthetic peptides by Lamb, J R, Zanders, E D, Lake, P, Webster, R G, Eckels, D D, Woody, J N, Green, N, Lerner, R A, Feldmann, M

“…While T cell proliferation to antigen in the presence of antigen-presenting cells is well known to be readily inhibited by antibodies directed against Class II…”
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Cloned Measles Virus-Specific T Lymphocytes from a Twin with Multiple Sclerosis by Richert, John R., McFarland, Henry F., McFarlin, Dale E., Bellini, William J., Lake, Phil

“…A measles virus-specific T lymphocyte clone derived from a measles-responder twin with multiple sclerosis has been produced. The cloned cells proliferate in…”
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Evidence for the erythrocyte as the principal antigenic cell type that triggers primary IgM antibody responses to H-2D alloantigens by Nakashima, I, Clark, E A, Lake, P, Kato, N, Nagase, F, Mizoguchi, K, Isobe, K I, Saito, M

“…Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens…”
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Cytotoxic and fluorescent assays for thymocyte subpopulations differing in surface thy-1 level by Shortman, K, Linthicum, D S, Battye, F L, Goldschneider, I, Liabeuf, A, Golstein, P, Clark, E A, Lake, P

“…A number of analytical techniques for distinguishing and separating the "high theta" "low theta" subpopulations of mouse thymocytes have been compared. A…”
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Demonstration with monoclonal antibody of the glycoprotein nature of Thy-1.2 alloantigen by Letarte, M, Addis, J, MacDonald, M E, Bernstein, A, Lake, P

“…Thy-1 antigen present in large amounts on the brain and thymus of mice, exists in two allelic forms, either Thy-1.1 or Thy-1.2. Previous results have shown…”
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Die neuen Duratorq-Dieselmotoren mit Direkteinspritzung im Ford Transit by Lawrence, Peter, Lake, Phil, Turtle, Dave, Tayler, Tony, Carnochan, William, Finch, Jerry, Gallett, Tony, Wölfle, Martin

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