Search Results - "Lake, Brian G"

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) by Yamada, Tomoya, Cohen, Samuel M., Lake, Brian G.

“…Many nongenotoxic chemicals have been shown to produce liver tumors in mice and/or rats by a mode of action (MOA) involving activation of the constitutive…”
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Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans by Mallick, Pankajini, Moreau, Marjory, Song, Gina, Efremenko, Alina Y, Pendse, Salil N, Creek, Moire R, Osimitz, Thomas G, Hines, Ronald N, Hinderliter, Paul, Clewell, Harvey J, Lake, Brian G, Yoon, Miyoung

“…Abstract To address concerns around age-related sensitivity to pyrethroids, a life-stage physiologically based pharmacokinetic (PBPK) model, supported by in…”
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Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse by Kondo, Miwa, Miyata, Kaori, Nagahori, Hirohisa, Sumida, Kayo, Osimitz, Thomas G, Cohen, Samuel M, Lake, Brian G, Yamada, Tomoya

“…Abstract The nongenotoxic pyrethroid insecticide permethrin produced hepatocellular tumors in CD-1 mice but not in Wistar rats. Recently, based on findings of…”
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Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes by Haines, Corinne, Elcombe, Barbara M., Chatham, Lynsey R., Vardy, Audrey, Higgins, Larry G., Elcombe, Clifford R., Lake, Brian G.

“…Phenobarbital (PB), a constitutive androstane receptor (CAR) activator, produces liver tumours in rodents by a mitogenic mode of action involving CAR…”
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Induction of drug metabolism: Species differences and toxicological relevance by Graham, Mark J, Lake, Brian G

“…Abstract A large number of drugs and other chemicals have been shown to induce hepatic microsomal cytochrome P450 (CYP) forms in experimental animals and…”
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Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes by Okuda, Yu, Kushida, Masahiko, Sumida, Kayo, Nagahori, Hirohisa, Nakamura, Yoshimasa, Higuchi, Hashihiro, Kawamura, Satoshi, Lake, Brian G, Cohen, Samuel M, Yamada, Tomoya

“…High dietary levels of momfluorothrin, a nongenotoxic synthetic pyrethroid, induced hepatocellular tumors in male and female Wistar rats in a 2-year bioassay…”
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Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin by Okuda, Yu, Kushida, Masahiko, Kikumoto, Hiroko, Nakamura, Yoshimasa, Higuchi, Hashihiro, Kawamura, Satoshi, Cohen, Samuel M., Lake, Brian G., Yamada, Tomoya

“…High dietary levels of the non-genotoxic synthetic pyrethroid momfluorothrin increased the incidence of hepatocellular tumors in male and female Wistar rats…”
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Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans by Osimitz, Thomas G., Droege, Wiebke, Boobis, Alan R., Lake, Brian G.

“…•We examined the 710 substances listed in the Carcinogenic Potency Database that were tested in both mice and rats.•Non-genotoxic mouse-only non-liver…”
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Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators by Lake, Brian G

“…A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving…”
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Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk by Osimitz, Thomas G., Lake, Brian G.

“…High doses of pyrethrins have been shown to produce liver tumors in female rats. Pyrethrins are not genotoxic agents. Pyrethrins produce liver tumors in rats…”
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Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes by Yamada, Tomoya, Kikumoto, Hiroko, Lake, Brian G, Kawamura, Satoshi

“…High doses of metofluthrin have been shown to produce hepatocellular tumours in rats. Previous in vivo and in vitro mode of action (MOA) studies have…”
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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes by Hirose, Yukihiro, Nagahori, Hirohisa, Yamada, Tomoya, Deguchi, Yoshihito, Tomigahara, Yoshitaka, Nishioka, Kazuhiko, Uwagawa, Satoshi, Kawamura, Satoshi, Isobe, Naohiko, Lake, Brian G, Okuno, Yasuyoshi

“…Abstract High doses of Metofluthrin (MTF) have been shown to produce liver tumours in rats by a mode of action (MOA) involving activation of the constitutive…”
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Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394 by Yamada, Tomoya, Cohen, Samuel M., Lake, Brian G

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Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action by Yamada, Tomoya, Lake, Brian G., Cohen, Samuel M.

“…The non-genotoxic synthetic pyrethroid insecticide permethrin produced hepatocellular adenomas and bronchiolo-alveolar adenomas in female CD-1 mice, but not in…”
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Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance by Goettel, Manuela, Werner, Christoph, Honarvar, Naveed, Gröters, Sibylle, Fegert, Ivana, Haines, Corinne, Chatham, Lynsey R., Vardy, Audrey, Lake, Brian G.

“…The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500…”
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Identification of Cytochrome P-450 Isoforms Responsible for cis-Tramadol Metabolism in Human Liver Microsomes by SUBRAHMANYAM, Vangala, RENWICK, Anthony B, WALTERS, David G, YOUNG, Philip J, PRICE, Roger J, TONELLI, Alfred P, LAKE, Brian G

“…The metabolism of cis -tramadol has been studied in human liver microsomes and in cDNA-expressed human cytochrome P-450 (CYP) isoforms. Human liver microsomes…”
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Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance by HAKOOZ, Nancy, ITO, Kiyomi, RAWDEN, Helen, GILL, Helen, LEMMERS, Lynn, BOOBIS, Alan R, EDWARDS, Robert J, CARLILE, David J, LAKE, Brian G, HOUSTON, J. Brian

“…To determine a microsomal scaling factor for human liver suitable for prediction of in vivo drug clearance from in vitro data and to explore the role of…”
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Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver by Yamada, Tomoya, Okuda, Yu, Kushida, Masahiko, Sumida, Kayo, Takeuchi, Hayato, Nagahori, Hirohisa, Fukuda, Takako, Lake, Brian G, Cohen, Samuel M, Kawamura, Satoshi

“…High doses of sodium phenobarbital (NaPB), a constitutive androstane receptor (CAR) activator, have been shown to produce hepatocellular tumors in rodents by a…”
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ELETRIPTAN METABOLISM BY HUMAN HEPATIC CYP450 ENZYMES AND TRANSPORT BY HUMAN P-GLYCOPROTEIN by EVANS, David C, O'CONNOR, Desmond, LAKE, Brian G, EVERS, Raymond, ALLEN, Christopher, HARGREAVES, Richard

“…“Reaction phenotyping” studies were performed with eletriptan (ETT) to determine its propensity to interact with coadministered medications. Its ability to…”
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Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice by Yamada, Tomoya, Ohara, Ayako, Ozawa, Naoya, Maeda, Keiko, Kondo, Miwa, Okuda, Yu, Abe, Jun, Cohen, Samuel M, Lake, Brian G

“…Using a chimeric mouse humanized liver model, we provided evidence that human hepatocytes are refractory to the mitogenic effects of rodent constitutive…”
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