Search Results - "Lakdawalla, Darius N."

Economics of the Pharmaceutical Industry by Lakdawalla, Darius N.

“…The pharmaceutical industry accounts for a substantial chunk of the US economy’s research and development investments, which have resulted in significant…”
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Defining Elements of Value in Health Care—A Health Economics Approach: An ISPOR Special Task Force Report [3] by Lakdawalla, Darius N., Doshi, Jalpa A., Garrison, Louis P., Phelps, Charles E., Basu, Anirban, Danzon, Patricia M.

“…The third section of our Special Task Force report identifies and defines a series of elements that warrant consideration in value assessments of medical…”
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Lifetime Economic Burden of Crohn’s Disease and Ulcerative Colitis by Age at Diagnosis by Lichtenstein, Gary R., MD, Shahabi, Ahva, MPH, PhD, Seabury, Seth A., PhD, Lakdawalla, Darius N., PhD, Espinosa, Oliver Díaz, PhD, Green, Sarah, BA, Brauer, Michelle, BS, Baldassano, Robert N., MD

“…Background & AimsUnderstanding the burden of Crohn’s disease (CD) and ulcerative colitis (UC) is important for measuring treatment value. We estimated lifetime…”
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Predicting Real-World Effectiveness of Cancer Therapies Using Overall Survival and Progression-Free Survival from Clinical Trials: Empirical Evidence for the ASCO Value Framework by Lakdawalla, Darius N., PhD, Shafrin, Jason, PhD, Hou, Ningqi, PhD, Peneva, Desi, MS, Vine, Seanna, MPH, Park, Jinhee, PhD, Zhang, Jie, PhD, Brookmeyer, Ron, PhD, Figlin, Robert A., MD, FACP

“…Abstract Objectives To measure the relationship between randomized controlled trial (RCT) efficacy and real-world effectiveness for oncology treatments as well…”
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Estimating the future burden of cardiovascular disease and the value of lipid and blood pressure control therapies in China by Stevens, Warren, Peneva, Desi, Li, Jim Z, Liu, Larry Z, Liu, Gordon, Gao, Runlin, Lakdawalla, Darius N

“…Lifestyle and dietary changes reflect an ongoing epidemiological transition in China, with cardiovascular disease (CVD) playing an ever-increasing role in…”
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Economic Burden of Community-Based Disease-Associated Malnutrition in the United States by Snider, Julia Thornton, Linthicum, Mark T., Wu, Yanyu, LaVallee, Chris, Lakdawalla, Darius N., Hegazi, Refaat, Matarese, Laura

“…Background: The burden imposed by disease-associated malnutrition (DAM) on patients and the healthcare system in food-abundant industrialized countries is…”
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Effect of Hospital Use of Oral Nutritional Supplementation on Length of Stay, Hospital Cost, and 30-Day Readmissions Among Medicare Patients With COPD by Snider, Julia Thornton, PhD, Jena, Anupam B., MD, PhD, Linthicum, Mark T., MPP, Hegazi, Refaat A., MD, PhD, MPH, Partridge, Jamie S., PhD, MBA, LaVallee, Chris, MS, Lakdawalla, Darius N., PhD, Wischmeyer, Paul E., MD

“…BACKGROUND COPD is a leading cause of death and disability in the United States. Patients with COPD are at a high risk of nutritional deficiency, which is…”
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Impact of non‐binding FDA guidances on primary endpoint selection in Alzheimer's disease trials by Yu, Jeffrey C., Hlávka, Jakub P., Joe, Elizabeth, Richmond, Frances J., Lakdawalla, Darius N.

“…Introduction The U.S. Food and Drug Administration (FDA)'s guidances help describe the agency's current thinking on regulatory issues and serve as a means of…”
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Health Technology Assessment With Diminishing Returns to Health: The Generalized Risk-Adjusted Cost-Effectiveness (GRACE) Approach by Lakdawalla, Darius N., Phelps, Charles E.

“…Cost-effectiveness analysis (CEA) embeds an assumption at odds with most economic analysis–that of constant returns to health in the creation of happiness…”
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Health technology assessment with risk aversion in health by Lakdawalla, Darius N., Phelps, Charles E.

“…Standard cost-effectiveness models compare incremental cost increases to incremental average gains in health, commonly expressed in Quality-Adjusted Life Years…”
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The welfare effects of medical malpractice liability by Lakdawalla, Darius N., Seabury, Seth A.

“…► We study the causal impact of medical malpractice liability on social welfare. ► Growth in malpractice payments contributed up to 15% of growth in medical…”
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Methods to Adjust Willingness-to-Pay Measures for Severity of Illness by Phelps, Charles E., Lakdawalla, Darius N.

“…Both private sector organizations and governmental health agencies increasingly use illness severity measures to adjust willingness-to-pay thresholds. Three…”
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Value of Reducing Wait Times for Chimeric Antigen Receptor T-Cell Treatment: Evidence From Randomized Controlled Trial Data on Tisagenlecleucel for Diffuse Large B-Cell Lymphoma by Chen, Alice J., Zhang, Jie, Agarwal, Abhijit, Lakdawalla, Darius N.

“…This study aimed to quantify the value of reducing chimeric antigen receptor T-cell (CAR-T) treatment wait times on patients with refractory and relapsed…”
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Healing the poor: The influence of patient socioeconomic status on physician supply responses by Chen, Alice, Lakdawalla, Darius N.

“…•Patient socioeconomic status systematically influences physician price responses.•The same physician can respond differently depending only on patient…”
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Three Pillars of Support for Orphan Drug Programs: Individual Valuations, Societal Valuations, and Anonymous Altruism by Lakdawalla, Darius N., Phelps, Charles E., Nguyen, Hong-Hanh

“…To identify and describe potential societal and individual sources of support for orphan drug programs. The Generalized Risk-Adjusted Cost-Effectiveness method…”
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Association Between Spending and Outcomes for Patients With Cancer by Li, Meng, Lakdawalla, Darius N, Goldman, Dana P

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A guide to extending and implementing generalized risk-adjusted cost-effectiveness (GRACE) by Lakdawalla, Darius N., Phelps, Charles E.

“…The generalized risk-adjusted cost-effectiveness (GRACE) model generalizes conventional cost-effectiveness analysis (CEA) by introducing diminishing returns to…”
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A principled approach to non-discrimination in cost-effectiveness by Lakdawalla, Darius N., Doctor, Jason N.

“…The US Inflation Reduction Act (IRA) prohibits the Centers for Medicare and Medicaid Services (CMS) from using standard quality-adjusted life-years or other…”
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Approaches to Aggregation and Decision Making—A Health Economics Approach: An ISPOR Special Task Force Report [5] by Phelps, Charles E., Lakdawalla, Darius N., Basu, Anirban, Drummond, Michael F., Towse, Adrian, Danzon, Patricia M.

“…The fifth section of our Special Task Force report identifies and discusses two aggregation issues: 1) aggregation of cost and benefit information across…”
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Impact of oral nutritional supplementation on hospital outcomes by Philipson, Thomas J, Snider, Julia Thornton, Lakdawalla, Darius N, Stryckman, Benoit, Goldman, Dana P

“…To assess the effect of inpatient oral nutritional supplement (ONS) use on length of stay, episode cost, and 30-day readmission probability. Eleven-year…”
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