Search Results - "Lajoie, J"

Rewriting the Genetic Code by Mukai, Takahito, Lajoie, Marc J, Englert, Markus, Söll, Dieter

“…The genetic code-the language used by cells to translate their genomes into proteins that perform many cellular functions-is highly conserved throughout…”
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Biocontainment of genetically modified organisms by synthetic protein design by Mandell, Daniel J., Lajoie, Marc J., Mee, Michael T., Takeuchi, Ryo, Kuznetsov, Gleb, Norville, Julie E., Gregg, Christopher J., Stoddard, Barry L., Church, George M.

“…Genetically modified organisms (GMOs) are increasingly deployed at large scales and in open environments. Genetic biocontainment strategies are needed to…”
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Codon usage of highly expressed genes affects proteome-wide translation efficiency by Frumkin, Idan, Lajoie, Marc J., Gregg, Christopher J., Hornung, Gil, Church, George M., Pilpel, Yitzhak

“…Although the genetic code is redundant, synonymous codons for the same amino acid are not used with equal frequencies in genomes, a phenomenon termed “codon…”
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Anthropogenic Seismicity Rates and Operational Parameters at the Salton Sea Geothermal Field by Brodsky, Emily E., Lajoie, Lia J.

“…Geothermal power is a growing energy source; however, efforts to increase production are tempered by concern over induced earthquakes. Although increased…”
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Design, synthesis, and testing toward a 57-codon genome by Ostrov, Nili, Landon, Matthieu, Guell, Marc, Kuznetsov, Gleb, Teramoto, Jun, Cervantes, Natalie, Zhou, Minerva, Singh, Kerry, Napolitano, Michael G., Moosburner, Mark, Shrock, Ellen, Pruitt, Benjamin W., Conway, Nicholas, Goodman, Daniel B., Gardner, Cameron L., Tyree, Gary, Gonzales, Alexandra, Wanner, Barry L., Norville, Julie E., Lajoie, Marc J., Church, George M.

“…Recoding–the repurposing of genetic codons–is a powerful strategy for enhancing genomes with functions not commonly found in nature. Here, we report…”
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Genomically Recoded Organisms Expand Biological Functions by Lajoie, Marc J., Rovner, Alexis J., Goodman, Daniel B., Aerni, Hans-Rudolf, Haimovich, Adrian D., Kuznetsov, Gleb, Mercer, Jaron A., Wang, Harris H., Carr, Peter A., Mosberg, Joshua A., Rohland, Nadin, Schultz, Peter G., Jacobson, Joseph M., Rinehart, Jesse, Church, George M., Isaacs, Farren J.

“…We describe the construction and characterization of a genomically recoded organism (GRO). We replaced all known UAG stop codons in Escherichia coli MG1655…”
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Drivers of rare earth elements (REEs) and radionuclides in changing subarctic (Nunavik, Canada) surface waters near a mining project by Marginson, H., MacMillan, G.A., Wauthy, M., Sicaud, E., Gérin-Lajoie, J., Dedieu, J.-P., Amyot, M.

“…The emergence of mining projects for rare earth elements (REEs) in response to rising global demand and geopolitical factors introduces environmental concerns,…”
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Probing the Limits of Genetic Recoding in Essential Genes by Lajoie, M. J., Kosuri, S., Mosberg, J. A., Gregg, C. J., Zhang, D., Church, G. M.

“…Engineering radically altered genetic codes will allow for genomically recoded organisms that have expanded chemical capabilities and are isolated from nature…”
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Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement by Isaacs, Farren J., Carr, Peter A., Wang, Harris H., Lajoie, Marc J., Sterling, Bram, Kraal, Laurens, Tolonen, Andrew C., Gianoulis, Tara A., Goodman, Daniel B., Reppas, Nikos B., Emig, Christopher J., Bang, Duhee, Hwang, Samuel J., Jewett, Michael C., Jacobson, Joseph M., Church, George M.

“…We present genome engineering technologies that are capable of fundamentally reengineering genomes from the nucleotide to the megabase scale. We used multiplex…”
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Improving lambda red genome engineering in Escherichia coli via rational removal of endogenous nucleases by Mosberg, Joshua A, Gregg, Christopher J, Lajoie, Marc J, Wang, Harris H, Church, George M

“…Lambda Red recombineering is a powerful technique for making targeted genetic changes in bacteria. However, many applications are limited by the frequency of…”
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Indigenous participation in peer review publications and the editorial process: reflections from a workshop by Loseto, L.L., Breton-Honeyman, K., Etiendem, D.N., Johnson, N., Pearce, T., Allen, J., Amos, A., Arqviq, J., Baak, J.E., Bélanger, É., Bourdages, M.P.T., Brammer, J.R., Fawcett, D., Gérin-Lajoie, J., Gilbert, G., Hansen-Craik, K., Loring, E., Perrin, A., Slavitch, M.

“…This communication paper reflects on discussions from a workshop about Indigenous involvement in the peer review and editorial processes. Arctic-based research…”
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Optimizing complex phenotypes through model-guided multiplex genome engineering by Kuznetsov, Gleb, Goodman, Daniel B, Filsinger, Gabriel T, Landon, Matthieu, Rohland, Nadin, Aach, John, Lajoie, Marc J, Church, George M

“…We present a method for identifying genomic modifications that optimize a complex phenotype through multiplex genome engineering and predictive modeling. We…”
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Overcoming Challenges in Engineering the Genetic Code by Lajoie, M.J., Söll, D., Church, G.M.

“…Withstanding 3.5billionyears of genetic drift, the canonical genetic code remains such a fundamental foundation for the complexity of life that it is highly…”
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A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers by Lajoie, J, Juno, J, Burgener, A, Rahman, S, Mogk, K, Wachihi, C, Mwanjewe, J, Plummer, F A, Kimani, J, Ball, T B, Fowke, K R

“…The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of…”
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Rational optimization of tolC as a powerful dual selectable marker for genome engineering by Gregg, Christopher J, Lajoie, Marc J, Napolitano, Michael G, Mosberg, Joshua A, Goodman, Daniel B, Aach, John, Isaacs, Farren J, Church, George M

“…Selection has been invaluable for genetic manipulation, although counter-selection has historically exhibited limited robustness and convenience. TolC, an…”
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Design and Beam Test Results for the sPHENIX Electromagnetic and Hadronic Calorimeter Prototypes by Aidala, C. A., Bailey, V., Beckman, S., Belmont, R., Biggs, C., Blackburn, J., Boose, S., Chiu, M., Connors, M., Desmond, E., Franz, A., Haggerty, J. S., He, X., Higdon, M. M., Huang, J., Kauder, K., Kistenev, E., LaBounty, J., Lajoie, J. G., Lenz, M., Lenz, W., Li, S., R.Loggins, V., Mannel, E. J., Majoros, T., McCumber, M. P., Nagle, J. L., Phipps, M., Pinkenburg, C., Polizzo, S., Pontieri, C., Purschke, M. L., Putschke, J., Sarsour, M., Rinn, T., Ruggiero, R., Sen, A., Sickles, A. M., Skoby, M. J., Smiga, J., Sobel, P., Stankus, P. W., Stoll, S., Sukhanov, A., Thorsland, E., Toldo, F., Towell, R. S., Ujvari, B., Vazquez-Carson, S., Woody, C. L.

“…The super Pioneering High Energy Nuclear Interaction eXperiment (sPHENIX) at the Relativistic Heavy Ion Collider will perform high-precision measurements of…”
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Tricyclic Compounds Containing Nonenolizable Cyano Enones. A Novel Class of Highly Potent Anti-Inflammatory and Cytoprotective Agents by Honda, Tadashi, Yoshizawa, Hidenori, Sundararajan, Chitra, David, Emilie, Lajoie, Marc J, Favaloro, Frank G, Janosik, Tomasz, Su, Xiaobo, Honda, Yukiko, Roebuck, Bill D, Gribble, Gordon W

“…Forty-four novel tricycles containing nonenolizable cyano enones (TCEs) were designed and synthesized on the basis of a semisynthetic pentacyclic triterpenoid,…”
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Comprehensive Proteomic Study Identifies Serpin and Cystatin Antiproteases as Novel Correlates of HIV-1 Resistance in the Cervicovaginal Mucosa of Female Sex Workers by Burgener, A, Rahman, S, Ahmad, R, Lajoie, J, Ramdahin, S, Mesa, C, Brunet, S, Wachihi, C, Kimani, J, Fowke, K, Carr, S, Plummer, F, Ball, T. B

“…Not all individuals exposed to HIV-1 become infected, and evidence from HIV-1 highly exposed seronegative women (HIV-1-resistant) suggests that mucosal factors…”
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Millstone: software for multiplex microbial genome analysis and engineering by Goodman, Daniel B, Kuznetsov, Gleb, Lajoie, Marc J, Ahern, Brian W, Napolitano, Michael G, Chen, Kevin Y, Chen, Changping, Church, George M

“…Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and…”
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Manipulating replisome dynamics to enhance lambda Red-mediated multiplex genome engineering by Lajoie, M J, Gregg, C J, Mosberg, J A, Washington, G C, Church, G M

“…Disrupting the interaction between primase and helicase in Escherichia coli increases Okazaki fragment (OF) length due to less frequent primer synthesis. We…”
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