Search Results - "Laird, Nan M."

Family-based designs in the age of large-scale gene-association studies by Laird, Nan M, Lange, Christoph

“…Both population-based and family-based designs are commonly used in genetic association studies to locate genes that underlie complex diseases. The simplest…”
Get full text

A new testing strategy to identify rare variants with either risk or protective effect on disease by Ionita-Laza, Iuliana, Buxbaum, Joseph D, Laird, Nan M, Lange, Christoph

“…Rapid advances in sequencing technologies set the stage for the large-scale medical sequencing efforts to be performed in the near future, with the goal of…”
Get full text

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes by Cho, Michael H, Castaldi, Peter J, Hersh, Craig P, Hobbs, Brian D, Barr, R Graham, Tal-Singer, Ruth, Bakke, Per, Gulsvik, Amund, San José Estépar, Raúl, Van Beek, Edwin J R, Coxson, Harvey O, Lynch, David A, Washko, George R, Laird, Nan M, Crapo, James D, Beaty, Terri H, Silverman, Edwin K

“…Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences…”
Get full text

Heritability of Chronic Obstructive Pulmonary Disease and Related Phenotypes in Smokers by ZHOU, Jin J, CHO, Michael H, CASTALDI, Peter J, HERSH, Craig P, SILVERMAN, Edwin K, LAIRD, Nan M

“…Previous studies of chronic obstructive pulmonary disease (COPD) have suggested that genetic factors play an important role in the development of disease…”
Get full text

Statistical Methods in the Journal — An Update by Sato, Yasunori, Gosho, Masahiko, Nagashima, Kengo, Takahashi, Sho, Ware, James H, Laird, Nan M

“…The authors surveyed the types of statistical methods used in the Journal during 2015. Investigators used a greater variety statistical methods, and the…”
Get full text

Estimating the Number of Unseen Variants in the Human Genome by Lonita-Laza, Luliana, Lange, Christoph, Laird, Nan M., Bickel, Peter J.

“…The different genetic variation discovery projects (The SNP Consortium, the International HapMap Project, the 1000 Genomes Project etc.) aim to identify as…”
Get full text

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution by Boueiz, Adel, Lutz, Sharon M, Cho, Michael H, Hersh, Craig P, Bowler, Russell P, Washko, George R, Halper-Stromberg, Eitan, Bakke, Per, Gulsvik, Amund, Laird, Nan M, Beaty, Terri H, Coxson, Harvey O, Crapo, James D, Silverman, Edwin K, Castaldi, Peter J, DeMeo, Dawn L

“…Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe-predominant emphysema has…”
Get full text

X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study by Hayden, Lystra P, Hobbs, Brian D, Busch, Robert, Cho, Michael H, Liu, Ming, Lopes-Ramos, Camila M, Lomas, David A, Bakke, Per, Gulsvik, Amund, Silverman, Edwin K, Crapo, James D, Beaty, Terri H, Laird, Nan M, Lange, Christoph, DeMeo, Dawn L

“…The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants…”
Get full text

The family based association test method: strategies for studying general genotype--phenotype associations by Horvath, S, Xu, X, Laird, N M

“…With possibly incomplete nuclear families, the family based association test (FBAT) method allows one to evaluate any test statistic that can be expressed as…”
Get full text

Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women by Sangrajrang, Suleeporn, Sato, Yasunori, Sakamoto, Hiromi, Ohnami, Sumiko, Laird, Nan M., Khuhaprema, Thiravud, Brennan, Paul, Boffetta, Paolo, Yoshida, Teruhiko

“…Estrogen and its metabolites are believed to play important roles in breast cancer, and its determinants include both genetic and lifestyle factors. The…”
Get full text

PBAT: Tools for Family-Based Association Studies by Lange, Christoph, DeMeo, Dawn, Silverman, Edwin K., Weiss, Scott T., Laird, Nan M.

Get full text

Genomewide Weighted Hypothesis Testing in Family-Based Association Studies, with an Application to a 100K Scan by Ionita-Laza, Iuliana, McQueen, Matthew B., Laird, Nan M., Lange, Christoph

“…For genomewide association (GWA) studies in family-based designs, we propose a novel two-stage strategy that weighs the association P values with the use of…”
Get full text

Biostatistic tools in pharmacogenomics--advances, challenges, potential by Sato, Yasunori, Laird, Nan M, Yoshida, Teruhiko

“…Inter-individual variations in drug response are all-too common and, throughout medical history have often posed problems, many of them serious ones. The…”
Get more information

Statistical analysis of longitudinal studies by Laird, Nan M.

“…Summary Longitudinal studies play a prominent role in research on growth, change and/or decline in individuals, and in characterising the environmental and…”
Get full text

Power Calculations for a General Class of Family-Based Association Tests: Dichotomous Traits by Lange, Christoph, Laird, Nan M.

“…Using large-sample theory, we present a unified approach to power calculations for family-based association tests. Currently available methods for power…”
Get full text

Genomic screening and replication using the same data set in family-based association testing by Van Steen, Kristel, McQueen, Matthew B, Herbert, Alan, Raby, Benjamin, Lyon, Helen, DeMeo, Dawn L, Murphy, Amy, Su, Jessica, Datta, Soma, Rosenow, Carsten, Christman, Michael, Silverman, Edwin K, Laird, Nan M, Weiss, Scott T, Lange, Christoph

“…The Human Genome Project and its spin-offs are making it increasingly feasible to determine the genetic basis of complex traits using genome-wide association…”
Get full text

Tutorial in Biostatistics: Evaluating the impact of ‘critical periods’ in longitudinal studies of growth using piecewise mixed effects models by Naumova, Elena N, Must, Aviva, Laird, Nan M

“…Recent developments in modern multivariate methods provide applied researchers with the means to address many important research questions that arise in…”
Get full text

Family-based association analysis of β2-adrenergic receptor polymorphisms in the Childhood Asthma Management Program by SILVERMAN, Edwin K, KWIATKOWSKI, David J, SYLVIA, Jody S, LAZARUS, Ross, DRAZEN, Jeffrey M, LANGE, Christoph, LAIRD, Nan M, WEISS, Scott T

Get full text

Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study by Moreno-Macías, Hortensia, Dockery, Douglas W, Schwartz, Joel, Gold, Diane R, Laird, Nan M, Sienra-Monge, Juan J, Del Río-Navarro, Blanca E, Ramírez-Aguilar, Matiana, Barraza-Villarreal, Albino, Li, Huiling, London, Stephanie J, Romieu, Isabelle

“…We previously reported that asthmatic children with GSTM1 null genotype may be more susceptible to the acute effect of ozone on the small airways and might…”
Get full text

On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test by Ionita-Laza, Iuliana, Perry, George H., Raby, Benjamin A., Klanderman, Barbara, Lee, Charles, Laird, Nan M., Weiss, Scott T., Lange, Christoph

“…Though there is an increasing support for an important contribution of copy number variation (CNV) to the genetic architecture of complex disease, few methods…”
Get full text