Search Results - "Laird, Jennifer M.A."

Wind-up of spinal cord neurones and pain sensation: much ado about something? by Herrero, J F, Laird, J M, López-García, J A

“…Wind-up is a frequency-dependent increase in the excitability of spinal cord neurones, evoked by electrical stimulation of afferent C-fibres. Although it has…”
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In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons by Galan, Alba, Laird, Jennifer M.A., Cervero, Fernando

“…The persistent increase in pain sensitivity observed after injury, known as hyperalgesia, depends on synaptic plasticity in the pain pathway, particularly in…”
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A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain by Yu, Xiao Hong, Cao, Chang Qing, Martino, Giovanni, Puma, Carole, Morinville, Anne, St-Onge, Stéphane, Lessard, Étienne, Perkins, Martin N., Laird, Jennifer M.A.

“…Cannabinoids are analgesic in man, but their use is limited by their psychoactive properties. One way to avoid cannabinoid receptor subtype 1 (CB1R)-mediated…”
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The Tetrodotoxin-Resistant Na+ Channel Nav1.8 is Essential for the Expression of Spontaneous Activity in Damaged Sensory Axons of Mice by Roza, Carolina, Laird, Jennifer M.A., Souslova, Veronika, Wood, John N., Cervero, Fernando

“…The tetrodotoxin-resistant sodium channel α subunit, Nav1.8, is exclusively expressed in primary sensory neurons and is suggested to play a role in the…”
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The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action by Martino, Giovanni, Puma, Carole, Yu, Xiao Hong, Gilbert, Annie-Kim, Coupal, Martin, Markoglou, Nektaria, McIntosh, Fraser S., Perkins, Martin N., Laird, Jennifer M.A.

“…The data presented show that the nonselective muscarinic agonist xanomeline is analgesic in models of persistent pain and suggest that the activation of…”
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Modality of hyperalgesia tested, not type of nerve damage, predicts pharmacological sensitivity in rat models of neuropathic pain by Pradhan, Amynah Amir Ali, Yu, Xiao Hong, Laird, Jennifer M.A

“…Abstract Although many types of nerve damage can cause neuropathic pain, there are substantial commonalities in neuropathic pain symptoms, and patients can be…”
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Mechanisms of touch-evoked pain (allodynia): a new model by Cervero, Fernando, Laird, Jennifer M A

“…In this paper we review the current neurophysiological models of touch-evoked pain and present a new proposal that addresses the mechanisms of allodynia. The…”
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Secondary hyperalgesia and presynaptic inhibition: an update by Cervero, Fernando, Laird, Jennifer M.A., Garcı́a-Nicas, Esther

“…One of the most prominent features of secondary hyperalgesia is touch-evoked pain, i.e., pain evoked by dynamic tactile stimuli applied to areas adjacent or…”
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Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia by Laird, Jennifer M.A., Garcı́a-Nicas, Esther, Delpire, Eric J., Cervero, Fernando

“…We have examined the role of the NKCC1 sodium-potassium-chloride-cotransporter in the generation of touch-evoked pain. The pain behavior of NKCC1 knockout mice…”
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Activation of spinal extracellular signaling-regulated kinase-1 and -2 by intraplantar carrageenan in rodents by Galan, Alba, Lopez-Garcia, J.Antonio, Cervero, Fernando, Laird, Jennifer M.A.

“…We have examined the activation of spinal extracellular signaling-regulated kinase (ERK) in juvenile rats and adult mice after intraplantar carrageenan or…”
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Looking at visceral pain: New vistas by Laird, Jennifer M.A, Cervero, Fernando

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Responses of rat spinal neurones to natural and electrical stimulation of colonic afferents: effect of inflammation by Olivar, Teresa, Cervero, Fernando, Laird, Jennifer M.A

“…Single unit electrical activity has been recorded from 107 neurones excited by electrical stimulation of the pelvic nerve in or around lamina X of the L6-S1…”
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Understanding the signaling and transmission of visceral nociceptive events by Cervero, Fernando, Laird, Jennifer M.A.

“…Visceral pain can be considered as part of the defense reactions of the body against harmful stimuli, particularly of those that impinge on the mucosal lining…”
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Visceral pain by Cervero, Fernando, Laird, Jennifer MA

“…Visceral pain is the most common form of pain produced by disease and one of the most frequent reasons why patients seek medical attention. Yet much of what we…”
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Deficits in Visceral Pain and Referred Hyperalgesia in Nav1.8 (SNS/PN3)-Null Mice by Laird, Jennifer M. A, Souslova, Veronika, Wood, John N, Cervero, Fernando

“…The tetrodotoxin-resistant sodium channel alpha subunit Nav1.8 is expressed exclusively in primary sensory neurons and is proposed to play an important role in…”
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Tailoring chronic pain treatments for the elderly: are we prepared for the challenge? by Arneric, Stephen P., Laird, Jennifer M.A., Chappell, Amy S., Kennedy, Jeffrey D.

“…•The ‘baby-boomer’ generation will double the elderly population in the USA by 2030.•Aging impacts nociceptive processing in humans and animals models.•Pain…”
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Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints by Viberg, Anders, Martino, Giovanni, Lessard, Etienne, Laird, Jennifer M. A.

“…Pre-clinical behavioral pharmacology studies supporting indications like analgesia typically consist of at least three different studies; dose-finding,…”
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Altered nociception, analgesia and aggression in mice lacking the receptor for substance P by Hunt, Stephen P, Felipe, Carmen De, Herrero, Juan F, O'Brien, John A, Palmer, James A, Doyle, Christopher A, Smith, Andrew J. H, Laird, Jennifer M. A, Belmonte, Carlos, Cervero, Fernando

“…The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete…”
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Neuromedin U Receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice by Gilbert, A.-K., Puma, C., Xu, X., Laird, J.M.A.

“…Background Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo‐nociception…”
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Role of rat sensory neuron-specific receptor (rSNSR1) in inflammatory pain: Contribution of TRPV1 to SNSR signaling in the pain pathway by Ndong, Christian, Pradhan, Amynah, Puma, Carole, Morello, Jean-Pierre, Hoffert, Cyrla, Groblewski, Thierry, O’Donnell, Dajan, Laird, Jennifer M.A.

“…Sensory neuron-specific receptors (SNSRs) belong to a large family of GPCRs, known as Mrgs ( Mas-related genes), many of which are preferentially expressed in…”
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