Search Results - "Laipis, P J"

Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors by SONG, S, EMBURY, J, LAIPIS, P. J, BERNS, K. I, CRAWFORD, J. M, FLOTTE, T. R

“…Previous work from our group showed that recombinant adeno-associated virus (rAAV) vectors mediated long-term secretion of therapeutic serum levels of human…”
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Long-term changes in glutamatergic synaptic transmission in phenylketonuria by Glushakov, A. V., Glushakova, O., Varshney, M., Bajpai, L. K., Sumners, C., Laipis, P. J., Embury, J. E., Baker, S. P., Otero, D. H., Dennis, D. M., Seubert, C. N., Martynyuk, A. E.

“…The cellular mechanisms that underlie impaired brain function during phenylketonuria (PKU), the most common biochemical cause of mental retardation in humans,…”
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Effect of DNA-Dependent Protein Kinase on the Molecular Fate of the rAAV2 Genome in Skeletal Muscle by Song, Sihong, Laipis, Philip J., Berns, Kenneth I., Flotte, Terence R.

“…We report here that the DNA-dependent protein kinase (DNA-PK) affects the molecular fate of the recombinant adeno-associated virus (rAAV) genome in skeletal…”
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Impaired glutamatergic synaptic transmission in the PKU brain by Martynyuk, A.E., Glushakov, A.V., Sumners, C., Laipis, P.J., Dennis, D.M., Seubert, C.N.

“…This paper reviews recent results of our investigation of the mechanisms whereby hyperphenylalaninemia may cause brain dysfunction in classical phenylketonuria…”
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Rapid segregation of heteroplasmic bovine mitochondria by ASHLEY, M. V, LAIPIS, P. J, HAUSWIRTH, W. W

“…By following the transmission of a heteroplasmic mitochondrial DNA mutation through four generations of Holstein cows, we have documented that substantial…”
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Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows by Hauswirth, W.W, Laipis, P.J

“…Two mitochondrial genotypes are shown to exist within one Holstein cow maternal lineage. They were detected by the appearance of an extra Hae III recognition…”
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Unequal Partitioning of Bovine Mitochondrial Genotypes among Siblings by Laipis, Philip J., Van De Walle, Michael J., Hauswirth, William W.

“…Two polymorphic mitochondrial DNA genomes, differing by a single Hpa II restriction site, are present at significantly different levels in tissue of three…”
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A T7 expression vector optimized for site-directed mutagenesis using oligodeoxyribonucleotide cassettes by Tanhauser, S M, Jewell, D A, Tu, C K, Silverman, D N, Laipis, P J

“…Site-directed mutagenesis is widely used to examine structure/function relationships in proteins. We have designed a bacterial expression vector series which…”
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Multiple copies of the bone-specific osteocalcin gene in mouse and rat by Rahman, S, Oberdorf, A, Montecino, M, Tanhauser, S M, Lian, J B, Stein, G S, Laipis, P J, Stein, J L

“…The osteocalcin (OC) gene was initially described as a single copy gene encoding the bone specific vitamin K dependent and vitamin D regulated protein. We…”
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Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III by Silverman, David N, Tu, Chingkuang, Chen, Xian, Tanhauser, Susan M, Kresge, A. Jerry, Laipis, Philip J

“…Maximal turnover rates for the dehydration of HCO3- catalyzed by the zinc metalloenzyme carbonic anhydrase III are limited by a proton transfer to zinc-bound…”
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Catalytic properties of mouse carbonic anhydrase V by Heck, R W, Tanhauser, S M, Manda, R, Tu, C, Laipis, P J, Silverman, D N

“…A cDNA encoding the mouse carbonic anhydrase V gene was isolated by reverse transcription and polymerase chain reaction from BALB/c mouse liver mRNA. Vectors…”
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Transcribed heteroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region by Ghivizzani, S.C. (University of Florida, Gainesville, FL), Mackay, S.L.D, Madsen, C.S, Laipis, P.J, Hauswirth, W.W

“…The mitochondrial D-loop region of the pig, Sus scrofa, was found to be several hundred base pairs larger than the corresponding region in cow, a related…”
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Mispairing and compensational changes during the evolution of mitochondrial ribosomal RNA by KRAUS, F, JARECKI, L, MIYAMOTO, M. M, TANHAUSER, S. M, LAIPIS, P. J

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Analysis of expressed sequence tags from Plasmodium falciparum by Chakrabarti, D, Reddy, G R, Dame, J B, Almira, E C, Laipis, P J, Ferl, R J, Yang, T P, Rowe, T C, Schuster, S M

“…An initiative was undertaken to sequence all genes of the human malaria parasite Plasmodium falciparum in an effort to gain a better understanding at the…”
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The Catalytic Properties of Human Carbonic Anhydrase IX by Wingo, Thomas, Tu, Chingkuang, Laipis, Philip J., Silverman, David N.

“…Human carbonic anhydrase IX (CA IX) is an integral membrane protein and a member of the α class of carbonic anhydrases that includes the human and animal…”
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Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis by Jewell, David A, Tu, Chingkuang, Paranawithana, Shanthi R, Tanhauser, Susan M, LoGrasso, Philip V, Laipis, Philip J, Silverman, David N

“…Among the seven known isozymes of carbonic anhydrase in higher vertebrates, isozyme III is the least efficient in catalytic hydration of CO2 and the least…”
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Demonstration of human papillomavirus DNA in oral condyloma acuminatum by Eversole, L R, Laipis, P J, Merrell, P, Choi, E

“…Condyloma acuminatum arising on oral mucous membranes exhibits distinct histopathological features that allow for differentiation from the more common squamous…”
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Template-directed arrest of mammalian mitochondrial DNA synthesis by MACKAY, S. L. D, OLIVO, P. D, LAIPIS, P. J, HAUSWIRTH, W. W

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice (∗) by Tanhauser, Susan M., Laipis, Philip J.

“…Mutational damage to human mitochondrial DNA (mtDNA) can cause disorders in oxidative phosphorylation; speculation that such damage is involved in degenerative…”
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Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22 by LAINE, R. O, LAIPIS, P. J, SHAY, N. F, KILBERG, M. S

“…Amino acid deprivation of rat hepatoma cells induced the levels of a 612-base pair mRNA termed ASI (Shay, N. F., Nick, H. S., and Kilberg, M. S. (1990) J…”
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