Search Results - "Laing, J"

ThermoTRPs and Pain by Laing, Robyn J, Dhaka, Ajay

“…The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors. The molecular receptors…”
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Immunobiology of Varicella-Zoster Virus Infection by Laing, Kerry J, Ouwendijk, Werner J D, Koelle, David M, Verjans, Georges M G M

“…Varicella-zoster virus (VZV) causes clinically significant illness during acute and recurrent infection accompanied by robust innate and acquired immune…”
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Cord compression defined by MRI is the driving factor behind the decision to operate in Degenerative Cervical Myelopathy despite poor correlation with disease severity by Hilton, Bryn, Tempest-Mitchell, Jennifer, Davies, Benjamin M, Francis, Jibin, Mannion, Richard J, Trivedi, Rikin, Timofeev, Ivan, Crawford, John R, Hay, Douglas, Laing, Rodney J, Hutchinson, Peter J, Kotter, Mark R N

“…The mainstay treatment for Degenerative Cervical Myelopathy (DCM) is surgical decompression. Not all cases, however, are suitable for surgery. Recent…”
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Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial by Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L, Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J, Koelle, David M, Frazer, Ian H

“…Genital herpes simplex infection affects more than 500 million people worldwide. We have previously shown that COR-1, a therapeutic HSV-2 polynucleotide…”
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Chemokines by Laing, Kerry J, Secombes, Christopher J

“…Chemokines are small proteins that control cellular migration. An extensive family of these molecules has been described in mammals containing nearly 50…”
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A comparison of radiological descriptions of spinal cord compression with quantitative measures, and their role in non-specialist clinical management by Tempest-Mitchell, Jennifer, Hilton, Bryn, Davies, Benjamin M, Nouri, Aria, Hutchinson, Peter J, Scoffings, Daniel J, Mannion, Richard J, Trivedi, Rikin, Timofeev, Ivan, Crawford, John R, Hay, Douglas, Laing, Rodney J, Kotter, Mark R N

“…Magnetic resonance imaging (MRI) is gold-standard for investigating Degenerative Cervical Myelopathy (DCM), a disabling disease triggered by compression of the…”
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A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish by Laing, Kerry J, Purcell, Maureen K, Winton, James R, Hansen, John D

“…A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information,…”
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Immunity to fish rhabdoviruses by Purcell, Maureen K, Laing, Kerry J, Winton, James R

“…Members of the family Rhabdoviridae are single-stranded RNA viruses and globally important pathogens of wild and cultured fish and thus relatively well studied…”
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Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster by Laing, Kerry J., Ouwendijk, Werner J. D., Campbell, Victoria L., McClurkan, Christopher L., Mortazavi, Shahin, Elder Waters, Michael, Krist, Maxwell P., Tu, Richard, Nguyen, Nhi, Basu, Krithi, Miao, Congrong, Schmid, D. Scott, Johnston, Christine, Verjans, Georges M. G. M., Koelle, David M.

“…Herpes zoster is a localized skin infection caused by reactivation of latent varicella-zoster virus. Tissue-resident T cells likely control skin infections…”
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Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia by van Gent, Michiel, Ouwendijk, Werner J D, Campbell, Victoria L, Laing, Kerry J, Verjans, Georges M G M, Koelle, David M

“…Trigeminal ganglia (TG) neurons are an important site of lifelong latent varicella-zoster virus (VZV) infection. Although VZV-specific T-cells are considered…”
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HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens by Koelle, David M, Dong, Lichun, Jing, Lichen, Laing, Kerry J, Zhu, Jia, Jin, Lei, Selke, Stacy, Wald, Anna, Varon, Dana, Huang, Meei-Li, Johnston, Christine, Corey, Lawrence, Posavad, Christine M

“…Antigen-specific T persist and protect against skin or female reproductive tract (FRT) HSV infection. As the pathogenesis of HSV differs between humans and…”
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The HSV-2 mutant ΔPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins by Colunga, A G, Laing, J M, Aurelian, L

“…Malignant melanoma is a highly aggressive and drug-resistant cancer. Virotherapy is a novel therapeutic strategy based on cancer cell lysis through selective…”
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HLA-B57:01 Complexed to a CD8 T-Cell Epitope from the HSV-2 ICP22 Protein Binds NK and T Cells through KIR3DL1 by Laing, Kerry J, Campbell, Victoria L, Dong, Lichun, Koelle, David M

“…HLA-B*57:01 is an HLA allelic variant associated with positive outcomes during viral infections through interactions with T cells and NK cells, but severe…”
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Bullying victimisation and paranoid ideation in people at ultra high risk for psychosis by Valmaggia, L.R, Day, F.L, Kroll, J, Laing, J, Byrne, M, Fusar-Poli, P, McGuire, P

“…Abstract Background Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that…”
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One night of sleep deprivation decreases treadmill endurance performance by Oliver, Samuel J., Costa, Ricardo J. S., Laing, Stewart J., Bilzon, James L. J., Walsh, Neil P.

“…The aim was to test the hypothesis that one night of sleep deprivation will impair pre-loaded 30 min endurance performance and alter the cardio-respiratory,…”
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A novel tool for the assessment of pain: validation in low back pain by Scholz, Joachim, Mannion, Richard J, Hord, Daniela E, Griffin, Robert S, Rawal, Bhupendra, Zheng, Hui, Scoffings, Daniel, Phillips, Amanda, Guo, Jianli, Laing, Rodney J C, Abdi, Salahadin, Decosterd, Isabelle, Woolf, Clifford J

“…Adequate pain assessment is critical for evaluating the efficacy of analgesic treatment in clinical practice and during the development of new therapies. Yet…”
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Interpersonal sensitivity in the at-risk mental state for psychosis by Masillo, A, Day, F, Laing, J, Howes, O, Fusar-Poli, P, Byrne, M, Bhattacharyya, S, Fiori Nastro, P, Girardi, P, McGuire, P K, Valmaggia, L R

“…Interpersonal sensitivity is a personality trait described as excessive awareness of both the behaviour and feelings of others. Although interpersonal…”
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Ictal face perception disturbance, tattoos, and reclaiming the self by Winton-Brown, T.T., Smith, L., Laing, J., O'Brien, T.J., Neal, A.

“…•Seizures arising from the occipito- temporal region may lead to face perception changes, or ‘prosopometamorphopsia’.•Ictal experiences may have significant…”
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Characterization of the interferon genes in homozygous rainbow trout reveals two novel genes, alternate splicing and differential regulation of duplicated genes by Purcell, Maureen K., Laing, Kerry J., Woodson, James C., Thorgaard, Gary H., Hansen, John D.

“…The genes encoding the type I and type II interferons (IFNs) have previously been identified in rainbow trout and their proteins partially characterized. These…”
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A review of geriatric injuries at a major trauma centre in South Africa by Da Costa, J-P, Laing, J, Kong, V Y, Bruce, J L, Laing, G L, Clarke, D L

“…Trauma in South Africa (SA) has been referred to as a malignant epidemic, but the impact of trauma on the elderly has tended to be overlooked. To address this…”
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