Search Results - "Lainez, Begona"

Human Extrafollicular CD4 + Th Cells Help Memory B Cells Produce Igs by Kim, Sang Taek, Choi, Jin-Young, Lainez, Begona, Schulz, Vincent P, Karas, David E, Baum, Eric D, Setlur, Jennifer, Gallagher, Patrick G, Craft, Joe

“…Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral…”
Get full text

Dynamic signaling by T follicular helper cells during germinal center B cell selection by Shulman, Ziv, Gitlin, Alexander D., Weinstein, Jason S., Lainez, Begoña, Esplugues, Enric, Flavell, Richard A., Craft, Joseph E., Nussenzweig, Michel C.

“…T follicular helper (TFH) cells select high-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the nature of their…”
Get full text

A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control by Xin, Gang, Schauder, David M., Lainez, Begoña, Weinstein, Jason S., Dai, Zhengxi, Chen, Yuhong, Esplugues, Enric, Wen, Renren, Wang, Demin, Parish, Ian A., Zajac, Allan J., Craft, Joe, Cui, Weiguo

“…Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the…”
Get full text

SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication by Meseguer, Salvador, Rubio, Mari-Paz, Lainez, Begoña, Pérez-Benavente, Beatriz, Pérez-Moraga, Raúl, Romera-Giner, Sergio, García-García, Francisco, Martinez-Macias, Olalla, Cremades, Antonio, Iborra, Francisco J, Candelas-Rivera, Oscar, Almazan, Fernando, Esplugues, Enric

“…Serine incorporator protein 5 (SERINC5) is a key innate immunity factor that operates in the cell to restrict the infectivity of certain viruses. Different…”
Get full text

A Polymorphism in the 3′ Untranslated Region of the Gene for Tumor Necrosis Factor Receptor 2 Modulates Reporter Gene Expression by Puga, Irene, Lainez, Begoña, Fernández-Real, José Manuel, Buxadé, Maria, Broch, Montserrat, Vendrell, Joan, Espel, Enric

“…The gene encoding the human TNFα receptor (TNFR) 2 contains polymorphisms in the 3′ untranslated region (UTR). Previous studies have shown that some variant…”
Get full text

Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2 by Lainez, Begoña, Fernandez‐Real, José Manuel, Romero, Xavier, Esplugues, Enric, Cañete, Juan D., Ricart, Wifredo, Engel, Pablo

“…Tumor necrosis factor (TNF)‐α is a pleiotropic cytokine involved in a broad spectrum of inflammatory and immune responses including proliferation,…”
Get full text

Human Extrafollicular CD4+ T Helper Cells Help Memory B Cells Produce Immunoglobulins by Kim, Sang Taek, Choi, Jin-Young, Lainez, Begona, Schulz, Vincent P., Karas, David E., Baum, Eric D., Setlur, Jennifer, Gallagher, Patrick G., Craft, Joe

“…Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral…”
Get full text

T sub(FH) cells progressively differentiate to regulate the germinal center response by Weinstein, Jason S, Herman, Edward I, Lainez, Begona, Licona-Limon, Paula, Esplugues, Enric, Flavell, Richard, Craft, Joe

“…Germinal center (GC) B cells undergo affinity selection, which depends on interactions with CD4 super(+) follicular helper T cells (T sub(FH) cells). We found…”
Get full text

Characterization of different subsets of human follicular helper T (TFH) cells (152.9) by Choi, Jinyoung, Kim, Sang Taek, Lainez, Begona, Craft, Joseph

“…Abstract Follicular helper T (TFH) cells are specialized CD4+ T cells that are localized in B cell follicles and help B cells produce antigen-specific…”
Get full text

Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus by Fernandez-Real, José-Manuel, Lainez, Begoña, Vendrell, Joan, Rigla, Mercedes, Castro, Antoni, Peñarroja, Georgina, Broch, Montserrat, Pérez, Antonio, Richart, Cristobal, Engel, Pablo, Ricart, Wifredo

“…Tumor necrosis factor-alpha (TNF-alpha) is increasingly recognized as a key component in the development of insulin resistance and increased blood pressure. In…”
Get more information

An alternative spliced variant of circulating soluble tumor necrosis factor-α receptor-2 is paradoxically associated with insulin action by Fernández-Real, José Manuel, Straczkowski, Marek, Lainez, Begoña, Chacón, Matilde R, Kowalska, Irina, López-Bermejo, Abel, García-España, Antonio, Nikolajuk, Agnieszka, Kinalska, Ida, Ricart, Wifredo

“…Objective: Serum concentrations of soluble tumor necrosis factor-α (TNF-α) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we…”
Get full text

An alternatively spliced soluble TNF-α receptor is associated with metabolic disorders A replication study by Fernández-Real, José Manuel, Botas-Cervero, Patricia, Lainez, Begoña, Ricart, Wifredo, Delgado, Elías

“…In a previous study, we identified a biologically active form of tumor necrosis factor-alpha receptor 2 (sTNFR2) produced by differential splicing (DS-TNFR2)…”
Get full text

Soluble TNF-α receptor 2 produced by alternative splicing is paradoxically associated with markers of liver injury by Esteve, Eduardo, Botas, Patricia, Delgado, Elías, López-Bermejo, Abel, Lainez, Begoña, Engel, Pablo, Ricart, Wifredo, Fernández-Real, Jose-Manuel

“…Abstract Tumor necrosis factor-α and insulin resistance play central roles in the pathogenesis of abnormal hepatocellular function. We evaluate the…”
Get full text

Characterization of Human Follicular Helper T (TFH ) Cells by Kim, Sang Taek, Choi, Jin-Young, DiPlacido, Leah, Lainez, Begona, Vlamakis, Vivian, Craft, Joe

Get full text

Clinical significance of high levels of soluble tumour necrosis factor-α receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study by CANETE, Juan D, ALBALADEJO, Carolina, SANMARTI, Raimon, VICTORIA HERNANDEZ, Maria, LAINEZ, Begona, PINTO, Jose A, RAMIREZ, Julio, JOSE LOPEZ-ARMADA, Maria, RODRIGUEZ-CROS, Jose R, ENGEL, Pablo, BLANCO, Francisco J

“…We investigated whether serum levels of an alternatively spliced soluble (s)TNF receptor-2 (DS-TNFR2) affected the clinical response to anti-TNF-α therapy,…”
Get full text

Follicular helper T cells progressively differentiate to regulate the germinal center response by Weinstein, Jason S., Herman, Edward I., Lainez, Begoña, Licona-Limón, Paula, Esplugues, Enric, Flavell, Richard, Craft, Joe

“…Germinal center (GC) B cells undergo affinity selection, dependent upon interactions with CD4 + follicular helper T (T FH ) cells. We demonstrate that T FH…”
Get full text

Progressive differentiation of follicular B helper T cells regulates the germinal center response (IRC11P.430) by Herman, Edward, Weinstein, Jason, Lainez, Begoña, Licona-Limón, Paula, Esplugues, Enric, Flavell, Richard, Craft, Joseph

“…Abstract Initiation of a thymus-dependent humoral immune response requires interaction of activated B cells and follicular B helper T (Tfh) cells, a…”
Get full text

Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity by Tomayko, Mary M, Karaaslan, Selda, Lainez, Begoña, Conter, Laura J, Song, Eunice, Venkatesan, Srividhya, Mishina, Yuji, Shlomchik, Mark J

“…In response to T-dependent Ag, germinal centers (GC) generate bone marrow-resident plasma cells (BMPC) and memory B cells (MBC). In this study, we demonstrate…”
Get full text

TFH cells progressively differentiate to regulate the germinal center response by Weinstein, Jason S, Herman, Edward I, Lainez, Begoña, Licona-Limón, Paula, Esplugues, Enric, Flavell, Richard, Craft, Joe

“…Craft and colleagues show that follicular helper T cells progress through transcriptionally and functionally distinct stages that provide specific signals for…”
Get full text

Antibacterial and antifungal effects of soft contact lens disinfection solutions by Cano-Parra, Juan, Bueno-Gimeno, Inmaculada, Lainez, Begoña, Córdoba, Juan, Montés-Micó, Robert

“…To study the antibacterial and antifungal effects of soft contact lens disinfection solutions. Eight contact lens disinfection solutions containing hydrogen…”
Get full text