Search Results - "Laine, A. P."

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes: indication of an increased environmental pressure? by HERMANN, R, KNIP, M, VEIJOLA, R, SIMELL, O, LAINE, A.-P, AKERBLOM, H. K, GROOP, P.-H, FORSBLOM, C, PETTERSSON-FERNHOLM, K, ILONEN, J

“…The incidence of Type 1 diabetes has increased 2.5 times during the time period from 1966 to 2000 in Finland-a general trend seen in almost all developed…”
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The association of the HLA‐A24:02, B39:01 and B39:06 alleles with type 1 diabetes is restricted to specific HLA‐DR/DQ haplotypes in Finns by Mikk, M.‐L., Heikkinen, T., El‐Amir, M. I., Kiviniemi, M., Laine, A.‐P., Härkönen, T., Veijola, R., Toppari, J., Knip, M., Ilonen, J.

“…Background We analysed the previously reported association of the HLA‐A*24:02, B*18 and B*39 alleles with type 1 diabetes and diabetes associated autoimmunity…”
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The HLA-B39 allele increases type 1 diabetes risk conferred by HLA-DRB104:04-DQB103:02 and HLA-DRB108-DQB104 class II haplotypes by Mikk, M-L, Kiviniemi, M, Laine, A-P, Härkönen, T, Veijola, R, Simell, O, Knip, M, Ilonen, J

“…To further characterise the effect of the HLA-B*39 allele on type 1 diabetes risk we assessed its role in different HLA-DR/DQ haplotypes and genotypes using…”
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interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations by Jermendy, A, Szatmári, I, Laine, A. P, Lukács, K, Horváth, K. H, Körner, A, Madácsy, L, Veijola, R, Simell, O, Knip, M, Ilonen, J, Hermann, R

“…Aims/hypothesis The rs1990760 polymorphism (Ala946Thr) of interferon induced with helicase C domain 1 (IFIH1) has been proposed to associate with type 1…”
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The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity by HERMANN, Robert, LAINE, A. P, VEIJOLA, R, VAHLBERG, T, SIMELL, S, LÄHDE, J, SIMELL, O, KNIP, M, ILONEN, J

“…The aim of this study was to explore the contribution of genetic factors to the emergence of beta-cell-specific humoral autoimmunity. We analysed the effect of…”
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Type 1 diabetes is insulin −2221 MspI and CTLA-4 +49 A/G polymorphism dependent by Haller, K., Kisand, K., Nemvalts, V., Laine, A.-P., Ilonen, J., Uibo, R.

“…Background  Several studies have demonstrated an association of type 1 diabetes with specific alleles of HLA class II molecules, as with polymorphisms of…”
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Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population by Laine, A-P, Turpeinen, H, Veijola, R, Hermann, R, Simell, O, Knip, M, Ilonen, J

“…IDDM9-region on chromosome 3q has shown suggestive evidence for linkage to type 1 diabetes in some but not all genome scans. We analyzed 22 microsatellite…”
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CD86 gene polymorphisms: no association with Type I diabetes among Finnish subjects by Turpeinen, H, Laine, A-P, Nejentsev, S, Sjöroos, M, Ilonen, J, Simell, O, Veijola, R, Knip, M, Akerblom, H K

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Transient but Not Permanent Neonatal Diabetes Mellitus is Associated With Paternal Uniparental Isodisomy of Chromosome 6 by Hermann, Robert, Laine, Antti-Pekka, Johansson, Calle, Niederland, Tamas, Tokarska, Lidia, Dziatkowiak, Hanna, Ilonen, Jorma, Soltesz, Gyula

“…The factors determining the pathogenesis of transient and permanent neonatal diabetes mellitus are poorly characterized. The purpose of this study was to…”
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Association of tumour necrosis factor a, b and c microsatellite polymorphisms with clinical disease activity and induction of remission in early rheumatoid arthritis by LAIVORANTA-NYMAN, S, MÖTTÖNEN, T, LAINE, A. P, TOIVANEN, A, ILONEN, J, HANNONEN, P, KORPELA, M, KAUTIAINEN, H, LEIRISALO-REPO, M, JULKUNEN, H, LUUKKAINEN, R, HAKALA, M, VUORI, K

“…To study the associations of tumor necrosis factor (TNF) a, b and c microsatellite markers with 1) the clinical disease activity and 2) the induction of…”
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GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy by Heinonen, Mirkka T, Laine, Antti-Pekka, Söderhäll, Cilla, Gruzieva, Olena, Rautio, Sini, Melén, Erik, Pershagen, Göran, Lähdesmäki, Harri J, Knip, Mikael, Ilonen, Jorma, Henttinen, Tiina A, Kere, Juha, Lahesmaa, Riitta

“…GTPase of the immunity-associated protein (GIMAP) family members are differentially regulated during human Th cell differentiation and have been previously…”
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The HLA-B∗ 39 allele increases type 1 diabetes risk conferred by HLA-DRB1∗ 04:04-DQB1∗ 03:02 and HLA-DRB1∗ 08-DQB1∗ 04 class II haplotypes by Mikk, M.-L, Kiviniemi, M, Laine, A.-P, Härkönen, T, Veijola, R, Simell, O, Knip, M, Ilonen, J

“…Abstract To further characterise the effect of the HLA-B∗ 39 allele on type 1 diabetes risk we assessed its role in different HLA-DR/DQ haplotypes and…”
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The genetic locus for free sialic acid storage disease maps to the long arm of chromosome 6 by HAATAJA, L, SCHLEUTKER, J, LAINE, A.-P, RENLUND, M, SAVONTAUS, M.-L, DIB, C, WEISSENBACH, J, PELTONEN, L, AULA, P

“…Salla disease (SD), or adult-type free sialic acid storage disease, is an autosomal recessive lysosomal storage disorder characterized by impaired transport of…”
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Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies by Lempainen, J, Härkönen, T, Laine, AP, Knip, M, Ilonen, J

“…Objective More than 50 loci outside the human leukocyte antigen (HLA) region have been confirmed to affect type 1 diabetes (T1D) risk but their effect on…”
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Transmission disequilibrium analysis of 31 type 1 diabetes susceptibility loci in Finnish families by Laine, A. P., Knip, M., Ilonen, J.

“…Currently more than 50 type 1 diabetes (T1D) loci outside the human leukocyte antigen (HLA)‐region have been established in large European and/or North…”
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Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B by NEJENTSEV, Sergei, GOMBOS, Zsofia, LAINE, Antti-Pekka, VEIJOLA, Riitta, KNIP, Mikael, SIMELL, Olli, VAARALA, Outi, AKERBLOM, Hans K, ILONEN, Jorma

“…Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. S Nejentsev , Z Gombos , A P Laine , R Veijola , M Knip , O Simell…”
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Linkage Disequilibrium Utilized to Establish a Refined Genetic Position of the Salla Disease Locus on 6q14-q15 by Schleutker, Johanna, Laine, Antti-Pekka, Haataja, Leena, Renlund, Martin, Weissenbach, Jean, Aula, Pertti, Peltonen, Leena

“…Salla disease (SD), an inherited free sialic acid storage disorder, is caused by impaired transport of free sialic acid across the lysosomal membrane. Clinical…”
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HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: An analysis of 622 nuclear families by Hermann, R., Turpeinen, H., Laine, A.P., Veijola, R., Knip, M., Simell, O., Sipilä, I., Åkerblom, H.K., Ilonen, J.

“…:  The diabetes predisposing effect of HLA genes is defined by a complex interaction of various haplotypes. We analyzed the disease association of HLA…”
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Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns by Nejentsev, S., Laine, A.-P., Simell, O., Ilonen, J.

“…The intercellular adhesion molecule‐1 (ICAM‐1) has an important role in the process of lymphocyte migration and activation, and is supposed to be involved in…”
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A linkage analysis of the CTLA4 gene region in Finnish patients with type 1 diabetes by Turpeinen, H., Laine, A. P., Hermann, R., Simell, O., Veijola, R., Knip, M., Ilonen, J.

“…Summary The cytotoxic T‐lymphocyte antigen 4 (CTLA4) region on 2q33 has been shown to be linked to, and associated with, type 1 diabetes (T1D) and suggested to…”
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