Search Results - "Laight, David"

A randomised placebo controlled trial of VSL#3 ® probiotic on biomarkers of cardiovascular risk and liver injury in non-alcoholic fatty liver disease by Chong, Pui Lin, Laight, David, Aspinall, Richard J, Higginson, Antony, Cummings, Michael H

“…Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk irrespective of conventional risk factors. The role of gut-liver…”
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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses by Khalaf, Maha, Scott-Ward, Toby, Causer, Adam, Saynor, Zoe, Shepherd, Anthony, Górecki, Dariusz, Lewis, Anthony, Laight, David, Shute, Janis

“…Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the…”
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Therapeutic inhibition of the renin angiotensin aldosterone system by Laight, David W

“…Inhibitors of the renin angiotensin aldosterone system (RAAS) represent some of the most widely prescribed, successful and well-tolerated therapeutics of…”
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Azo compounds in colon-specific drug delivery by Roldo, Marta, Barbu, Eugen, Brown, James F, Laight, David W, Smart, John D, Tsibouklis, John

“…Azo compounds have the potential to act as drug carriers that facilitate the selective release of therapeutic agents to the colon, and also to effect the oral…”
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Attitudes to concept maps as a teaching learning activity in undergraduate health professional education: influence of preferred learning style by Laight, David W.

“…Concept maps that integrate and relate concepts in a nonlinear fashion are widely accepted as an educational tool that can underpin meaningful learning in…”
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Attitudes to concept maps as a teaching/learning activity in undergraduate health professional education: influence of preferred approach to learning by Laight, David W.

“…Pre-prepared concept maps that organise knowledge in a non-linear fashion appeal to a variety of cognitive learning styles and may thus represent an…”
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Raising awareness of drug‐micronutrient interactions by Laight, David

“…Vitamin and mineral depletion is an often under‐recognised side‐effect of pharmacotherapy. This article considers a number of common drug‐micronutrient…”
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Risk communication: a pillar of shared decision making by Laight, David

“…Shared decision making (SDM) between patients and healthcare professionals about tests, treatments and care reflects many NHS values and firmly establishes…”
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Can fish oils help to prevent cardiovascular disease? by Laight, David

“…Omega‐3 fish oils have attracted much interest in light of their anticipated cardiovascular protective effects, but the actual clinical evidence base for their…”
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Attitudes to aspirin use in diabetes in clinical practice: a survey of health care professionals from primary and secondary care settings in the UK by Raghavan, Rajeev, Laight, David W, Cummings, Michael H

“…Aspirin is recommended for secondary prevention in diabetes and macrovascular disease. However, recommendation for primary prevention in diabetes remains…”
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Capturing glucose variability in patients with diabetes by Laight, David

“…Measurement of glycated haemoglobin (HbA1c) as a marker of glycaemic control has become a cornerstone in the management of diabetes, while also predicting…”
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F2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: effects of vitamin E by LAIGHT, D. W, DESAI, K. M, GOPAUL, N. K, ÄNGGARD, E. E, CARRIER, M. J

“…We have concurrently investigated oxidant stress, glucose tolerance and glucose-stimulated insulin responses in the obese Zucker rat, a widely used model of…”
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Orally administered, colon-specific mucoadhesive azopolymer particles for the treatment of inflammatory bowel disease: An in vivo study by Roldo, Marta, Barbu, Eugen, Brown, James F., Laight, David W., Smart, John D., Tsibouklis, John

“…Radiolabeled congeners of a series of azopolymers have been synthesized and characterized. The in vivo (rat) gastrointestinal transit profile of…”
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Cardiovascular risk prediction for primary prevention by Laight, David

“…Risk prediction tools such as QRISK identify those at higher risk of heart attack and stroke, based on traditional and emerging cardiovascular risk factors,…”
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The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomised placebo controlled trial by Atkin, Marc, Laight, David, Cummings, Michael H

“…Abstract Background and aims Endothelial dysfunction, vascular inflammation and oxidative stress have been integrally linked to the pathogenesis of both type 2…”
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Nitrate tolerance and the links with endothelial dysfunction and oxidative stress by Fayers, Katherine E., Cummings, Michael H., Shaw, Kenneth M., Laight, David W.

“…Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial…”
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Can LDL cholesterol ever be lowered too much? by Laight, David

“…Current guidelines recommend reducing LDL cholesterol by specified amounts; however, a new treatment ‘lower is better’ paradigm advocates more dramatic LDL…”
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Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts by Edgar, Suzanne, Hopley, Blake, Genovese, Licia, Sibilla, Sara, Laight, David, Shute, Janis

“…Nutraceuticals containing collagen peptides, vitamins, minerals and antioxidants are innovative functional food supplements that have been clinically shown to…”
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Accounting for cardiovascular risk when prescribing NSAIDs by Laight, David

“…It is now recognised that oral NSAIDs can increase the risk of cardiovascular events, including myocardial infarction and stroke. This article discusses the…”
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Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function by Laight, David W, Kaw, Amar V, Carrier, Martin J, Änggård, Erik E

“…Nitric oxide (NO)‐mediated, endothelium‐dependent vasodilator function in rat aortic smooth muscle was investigated in an in vitro model of endogenous vascular…”
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