Search Results - "Laidlaw, Stephen M."

TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease by Jones, Esther L, Laidlaw, Stephen M, Dustin, Lynn B

“…TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an…”
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Interferon lambda: opportunities, risks, and uncertainties in the fight against HCV by Laidlaw, Stephen M, Dustin, Lynn B

“…Innate immunity is key to the fight against the daily onslaught from viruses that our bodies are subjected to. Essential to this response are the interferons…”
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Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2 by Cornish, Katy, Huo, Jiandong, Jones, Luke, Sharma, Parul, Thrush, Joseph W, Abdelkarim, Sahar, Kipar, Anja, Ramadurai, Siva, Weckener, Miriam, Mikolajek, Halina, Liu, Sai, Buckle, Imogen, Bentley, Eleanor, Kirby, Adam, Han, Ximeng, Laidlaw, Stephen M, Hill, Michelle, Eyssen, Lauren, Norman, Chelsea, Le Bas, Audrey, Clarke, John, James, William, Stewart, James P, Carroll, Miles, Naismith, James H, Owens, Raymond J

“…The Omicron strains of SARS-CoV-2 pose a significant challenge to the development of effective antibody-based treatments as immune evasion has compromised most…”
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Enhanced T Cell-Mediated Protection against Malaria in Human Challenges by Using the Recombinant Poxviruses FP9 and Modified Vaccinia virus Ankara by Webster, Daniel P., Dunachie, Susanna, Vuola, Jenni M., Berthoud, Tamara, Keating, Sheila, Laidlaw, Stephen M., McConkey, Samuel J., Poulton, Ian, Andrews, Laura, Andersen, Rikke F., Bejon, Philip, Butcher, Geoff, Sinden, Robert, Skinner, Michael A., Gilbert, Sarah C., Adrian V. S. Hill, Miller, Louis H.

“…Malaria is a major global health problem for which an effective vaccine is required urgently. Prime-boost vaccination regimes involving plasmid DNA and…”
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Genetic Screen of a Library of Chimeric Poxviruses Identifies an Ankyrin Repeat Protein Involved in Resistance to the Avian Type I Interferon Response by Buttigieg, Karen, Laidlaw, Stephen M, Ross, Craig, Davies, Marc, Goodbourn, Stephen, Skinner, Michael A

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Genetic Screen of a Mutant Poxvirus Library Identifies an Ankyrin Repeat Protein Involved in Blocking Induction of Avian Type I Interferon by Laidlaw, Stephen M, Robey, Rebecca, Davies, Marc, Giotis, Efstathios S, Ross, Craig, Buttigieg, Karen, Goodbourn, Stephen, Skinner, Michael A

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Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus' Lateral Body Protein by Giotis, Efstathios S, Laidlaw, Stephen M, Bidgood, Susanna R, Albrecht, David, Burden, Jemima J, Robey, Rebecca C, Mercer, Jason, Skinner, Michael A

“…The avian pathogen fowlpox virus (FWPV) has been successfully used as a vaccine vector in poultry and humans, but relatively little is known about its ability…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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Alkyne Derivatives of SARS-CoV‑2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine by Brewitz, Lennart, Dumjahn, Leo, Zhao, Yilin, Owen, C. David, Laidlaw, Stephen M., Malla, Tika R., Nguyen, Dung, Lukacik, Petra, Salah, Eidarus, Crawshaw, Adam D., Warren, Anna J., Trincao, Jose, Strain-Damerell, Claire, Carroll, Miles W., Walsh, Martin A., Schofield, Christopher J.

“…Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination with ritonavir, is used to treat infections by severe acute…”
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An HCV Vaccine on the Fly by Laidlaw, Stephen M, Dustin, Lynn B

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A prototype lateral flow assay for detection of orthopoxviruses by Ulaeto, David O, Lonsdale, Steve G, Laidlaw, Stephen M, Clark, Graeme C, Horby, Peter, Carroll, Miles W

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Convalescent plasma donors show enhanced cross‐reactive neutralizing antibody response to antigenic variants of SARS‐CoV‐2 following immunization by Harvala, Heli, Nguyen, Dung, Simmonds, Peter, Lamikanra, Abigail A., Tsang, Hoi Pat, Otter, Ashley, Maes, Piet, Webster, Mhairi, Clarkson, Adam, Kaloyirou, Fotini, Hopkins, Valerie, Laidlaw, Stephen M., Carroll, Miles, Mora, Ana, Griffiths, Alexandra, MacLennan, Sheila, Estcourt, Lise, Roberts, David J.

“…Background The therapeutic benefit of convalescent plasma (CP) therapy to treat COVID‐19 may derive from neutralizing antibodies (nAbs) to SARS‐CoV‐2. To…”
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Immune control and failure in HCV infection—tipping the balance by Dustin, Lynn B., Cashman, Siobhán B., Laidlaw, Stephen M.

“…Review on the innate and adaptive immune responses to Hepatitis C virus. Despite the development of potent antiviral drugs, HCV remains a global health…”
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Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons by Laidlaw, Stephen M, Marukian, Svetlana, Gilmore, Rachel H, Cashman, Siobhán B, Nechyporuk-Zloy, Volodymyr, Rice, Charles M, Dustin, Lynn B

“…Background & Aims Tumor necrosis factor (TNF) is an inflammatory cytokine expressed by human fetal liver cells (HFLCs) after infection with cell…”
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Avipoxvirus phylogenetics: identification of a PCR length polymorphism that discriminates between the two major clades by Jarmin, Susan, Manvell, Ruth, Gough, Richard E, Laidlaw, Stephen M, Skinner, Michael A

“…1 Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK 2 Veterinary Laboratory Agency, New Haw, Addlestone, Surrey KT15 3NB, UK Correspondence…”
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Identification and Characterization of Three Immunodominant Structural Proteins of Fowlpox Virus by Boulanger, Denise, Green, Philip, Jones, Brenda, Henriquet, Gwenn, Hunt, Lawrence G, Laidlaw, Stephen M, Monaghan, Paul, Skinner, Michael A

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Comparison of the genome sequence of FP9, an attenuated, tissue culture-adapted European strain of Fowlpox virus, with those of virulent American and European viruses by Laidlaw, Stephen M, Skinner, Michael A

“…Institute for Animal Health, Division of Molecular Biology, Compton, Newbury, Berks RG20 7NN, UK Correspondence Michael A. Skinner…”
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Enhanced CD8+ T Cell Immune Responses and Protection Elicited against Plasmodium berghei Malaria by Prime Boost Immunization Regimens Using a Novel Attenuated Fowlpox Virus by Anderson, Richard J, Hannan, Carolyn M, Gilbert, Sarah C, Laidlaw, Stephen M, Sheu, Eric G, Korten, Simone, Sinden, Robert, Butcher, Geoffrey A, Skinner, Michael A, Hill, Adrian V. S

“…Sterile immunity can be provided against the pre-erythrocytic stages of malaria by IFN-gamma-secreting CD8(+) T cells that recognize parasite-infected…”
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Fowlpox virus as a recombinant vaccine vector for use in mammals and poultry by Skinner, Michael A, Laidlaw, Stephen M, Eldaghayes, Ibrahim, Kaiser, Pete, Cottingham, Matthew G

“…Live vaccines against fowlpox virus, which causes moderate pathology in poultry and is the type species of the Avipoxvirus genus, were developed in the 1920s…”
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Construction of Deletion-knockout Mutant Fowlpox Virus (FWPV) by Stephen Laidlaw, Michael Skinner

“…The construction of deletion-knockout poxviruses is a useful approach to determining the function of specific virus genes. This protocol is an adaptation of…”
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