Search Results - "Lai, Yanhao"

Replication Stress and Consequential Instability of the Genome and Epigenome by Tsegay, Pawlos S, Lai, Yanhao, Liu, Yuan

“…Cells must faithfully duplicate their DNA in the genome to pass their genetic information to the daughter cells. To maintain genomic stability and integrity,…”
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Dynamic single-cell intracellular pH sensing using a SERS-active nanopipette by Guo, Jing, Sesena Rubfiaro, Alberto, Lai, Yanhao, Moscoso, Joseph, Chen, Feng, Liu, Yuan, Wang, Xuewen, He, Jin

“…Glass nanopipettes have shown promise for applications in single-cell manipulation, analysis, and imaging. In recent years, plasmonic nanopipettes have been…”
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Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots by Kompella, Pallavi, Wang, Guliang, Durrett, Russell E., Lai, Yanhao, Marin, Celeste, Liu, Yuan, Habib, Samy L., DiGiovanni, John, Vasquez, Karen M.

“…Obesity is associated with increased cancer risk, yet the underlying mechanisms remain elusive. Obesity-associated cancers involve disruptions in metabolic and…”
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DNA Base Damage Repair Crosstalks with Chromatin Structures to Contract Expanded GAA Repeats in Friedreich's Ataxia by Lai, Yanhao, Diaz, Nicole, Armbrister, Rhyisa, Agoulnik, Irina, Liu, Yuan

“…Trinucleotide repeat (TNR) expansion is the cause of over 40 neurodegenerative diseases, including Huntington's disease and Friedreich's ataxia (FRDA). There…”
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Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair by Lai, Yanhao, Budworth, Helen, Beaver, Jill M., Chan, Nelson L. S., Zhang, Zunzhen, McMurray, Cynthia T., Liu, Yuan

“…Studies in knockout mice provide evidence that MSH2–MSH3 and the BER machinery promote trinucleotide repeat (TNR) expansion, yet how these two different repair…”
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Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair by Lai, Yanhao, Xu, Meng, Zhang, Zunzhen, Liu, Yuan

“…Trinucleotide repeat (TNR) expansions and deletions are associated with human neurodegeneration and cancer. However, their underlying mechanisms remain to be…”
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A partial Drp1 knockout improves autophagy flux independent of mitochondrial function by Fan, Rebecca Z, Sportelli, Carolina, Lai, Yanhao, Salehe, Said S, Pinnell, Jennifer R, Brown, Harry J, Richardson, Jason R, Luo, Shouqing, Tieu, Kim

“…Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of…”
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Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells by Zhang, Manqi, Lai, Yanhao, Vasquez, Judy L., James, Dominic I., Smith, Kate M., Waddell, Ian D., Ogilvie, Donald J., Liu, Yuan, Agoulnik, Irina U.

“…There is mounting evidence of androgen receptor signaling inducing genome instability and changing DNA repair capacity in prostate cancer cells. Expression of…”
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Antioxidant activities of Ganoderma lucidum polysaccharides and their role on DNA damage in mice induced by cobalt-60 gamma-irradiation by Zhao, Wei, Jiang, Xuejun, Deng, Wenwen, Lai, Yanhao, Wu, Mei, Zhang, Zunzhen

“…► The radio-protective activity of Ganoderma lucidum polysaccharides (GLP) from sporoderm-broken spore powder was firstly studied. ► GLP show protective…”
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The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells by Luo, Qingying, Li, Yang, Lai, Yanhao, Zhang, Zunzhen

“…The therapeutic efficacy of arsenic trioxide (ATO) for treatments of solid tumors is restricted by its drug resistance and chemotoxicity. In this study, we…”
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Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q by Ren, Yaou, Lai, Yanhao, Laverde, Eduardo E, Lei, Ruipeng, Rein, Hayley L, Liu, Yuan

“…Trinucleotide repeat (TNR) instability is associated with human neurodegenerative diseases and cancer. Recent studies have pointed out that DNA base excision…”
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An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract by Beaver, Jill M, Lai, Yanhao, Rolle, Shantell J, Weng, Liwei, Greenberg, Marc M, Liu, Yuan

“…Oxidative DNA damage and base excision repair (BER) play important roles in modulating trinucleotide repeat (TNR) instability that is associated with human…”
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Base excision repair of chemotherapeutically-induced alkylated DNA damage predominantly causes contractions of expanded GAA repeats associated with Friedreich's ataxia by Lai, Yanhao, Beaver, Jill M, Lorente, Karla, Melo, Jonathan, Ramjagsingh, Shyama, Agoulnik, Irina U, Zhang, Zunzhen, Liu, Yuan

“…Expansion of GAA·TTC repeats within the first intron of the frataxin gene is the cause of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative…”
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Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase by Jiang, Zhongliang, Lai, Yanhao, Beaver, Jill M, Tsegay, Pawlos S, Zhao, Ming-Lang, Horton, Julie K, Zamora, Marco, Rein, Hayley L, Miralles, Frank, Shaver, Mohammad, Hutcheson, Joshua D, Agoulnik, Irina, Wilson, Samuel H, Liu, Yuan

“…DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular…”
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Role of DNA polymerase beta in the genotoxicity of arsenic by Lai, Yanhao, Zhao, Wei, Chen, Chen, Wu, Mei, Zhang, Zunzhen

“…Arsenic, an important hazard in the environment, is associated with human cancer and other degenerative diseases. However, the mechanisms underlying arsenic…”
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Diastereomeric Recognition of 5',8-cyclo-2'-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model by Masi, Annalisa, Sabbia, Arianna, Ferreri, Carla, Manoli, Francesco, Lai, Yanhao, Laverde, Eduardo, Liu, Yuan, Krokidis, Marios G, Chatgilialoglu, Chryssostomos, Faraone Mennella, Maria Rosaria

“…5',8-Cyclo-2'-deoxyadenosine (cdA), in the 5' and 5' diastereomeric forms, are typical non strand-break oxidative DNA lesions, induced by hydroxyl radicals,…”
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Deregulated expression of DNA polymerase β is involved in the progression of genomic instability by Luo, Qingying, Lai, Yanhao, Liu, Shukun, Wu, Mei, Liu, Yuan, Zhang, Zunzhen

“…Deregulated expression of DNA polymerase beta (pol β) has been implicated in genomic instability that leads to tumorigenesis, yet the mechanisms underlying the…”
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Links between DNA polymerase beta expression and sensitivity to bleomycin by Liu, Shukun, Lai, Yanhao, Zhao, Wei, Wu, Mei, Zhang, Zunzhen

“…Abstract Bleomycin (BLM), an important anti-tumor antibiotic, enables cell death through oxidative DNA damage mediated by reactive oxygen species (ROS)…”
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N 6 -methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation by Zhao, Tianhe, Sun, Donglei, Zhao, Manyu, Lai, Yanhao, Liu, Yuan, Zhang, Zunzhen

“…N -methyladenosine (m A), the most abundant and reversible RNA modification, plays critical a role in tumorigenesis. However, whether m A can regulate p53, a…”
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miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells by Gu, Shiyan, Lai, Yanhao, Chen, Hongyu, Liu, Yuan, Zhang, Zunzhen

“…Arsenic trioxide (ATO) resistance is a challenging problem in chemotherapy. However, the underlying mechanisms remain to be elucidated. In this study, we…”
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