Search Results - "Lai, Xianning"

Triple negative breast cancer in Asia: An insider’s view by Wang, Chao, Kar, Shreya, Lai, Xianning, Cai, Wanpei, Arfuso, Frank, Sethi, Gautam, Lobie, Peter E., Goh, Boon C., Lim, Lina H.K., Hartman, Mikael, Chan, Ching W., Lee, Soo C., Tan, Sing H., Kumar, Alan P.

“…•A comprehensive introduction on the characteristics of TNBC and its heterogeneity.•A comprehensive comparison of TNBC prevalence in Western and Asian…”
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MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells by Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena

“…Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2…”
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BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity by Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena

“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous…”
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Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance by Tacconi, Eliana MC, Badie, Sophie, De Gregoriis, Giuliana, Reisländer, Timo, Lai, Xianning, Porru, Manuela, Folio, Cecilia, Moore, John, Kopp, Arnaud, Baguña Torres, Júlia, Sneddon, Deborah, Green, Marcus, Dedic, Simon, Lee, Jonathan W, Batra, Ankita Sati, Rueda, Oscar M, Bruna, Alejandra, Leonetti, Carlo, Caldas, Carlos, Cornelissen, Bart, Brino, Laurent, Ryan, Anderson, Biroccio, Annamaria, Tarsounas, Madalena

“…Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐ mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour…”
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Correction: Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells by Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena

“…Nature Communications 8: Article number: 15983 (2017); Published: 17 July 2017; Updated: 26 October 2017 In this Article, there are errors in the labelling of…”
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Molecular Basis for Lysine Specificity in the Yeast Ubiquitin-Conjugating Enzyme Cdc34 by Sadowski, Martin, Suryadinata, Randy, Lai, Xianning, Heierhorst, Jörg, Sarcevic, Boris

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition by Lai, Xianning, Lui, Sarah Kit Leng, Lam, Hiu Yan, Adachi, Yuta, Sim, Wen Jing, Vasilevski, Natali, Armstrong, Nicola J., Bridgeman, Stephanie Claire, Main, Nathan Michael, Tan, Tuan Zea, Tirnitz-Parker, Janina E. E., Thiery, Jean Paul, Ebi, Hiromichi, Kumar, Alan Prem, Eichhorn, Pieter Johan Adam

“…Despite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic window…”
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Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial by Chooi, Yu Chung, Zhang, Qinze Arthur, Magkos, Faidon, Ng, Maisie, Michael, Navin, Wu, Xiaorong, Volchanskaya, Vera Sergeyevna Brok, Lai, Xianning, Wanjaya, Elvy Riani, Elejalde, Untzizu, Goh, Chew Chan, Yap, Clara Poh Lian, Wong, Long Hui, Lim, Kevin Junliang, Velan, S. Sendhil, Yaligar, Jadegoud, Muthiah, Mark Dhinesh, Chong, Yap Seng, Loo, Evelyn Xiu Ling, Eriksson, Johan G., Lim, Kezlyn Li Ming, Kouk, Mabel Shu Fung, Mei Chong, Evelyn Wai, Gani, Munirah Abd, Li, Lisha, Tay, Vicky Hwee Kee, Kway, Yeshe Manuel, Kumar, Mukkesh, Sadananthan, Suresh Anand, Khoo, Kaijie, Koh, Danyu, Lim, Rebecca, Kang, Chin Wei, Sin, Kwang Li, Lim, Jun Wei

“…Weight loss is the most effective treatment for nonalcoholic fatty liver disease (NAFLD). There is evidence that the Mediterranean diets rich in unsaturated…”
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Abstract A28: DEAD-box RNA helicase DP103 enhances YAP sumoylation for YAP-TEAD dependence and statin sensitivity in triple-negative breast cancer by Lai, Xianning, Wang, Tingting, Tan, Tuan Zea, Casey, Patrick J, Hong, Wanjin, Sudol, Marius, Tergaonkar, Vinay, Lee, Soo Chin, Kumar, Alan Prem

“…Abstract Simvastatin (SMV), a lipophilic statin used for lowering cholesterol, inhibits 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme of the…”
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Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells by Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena

“…This corrects the article DOI: 10.1038/ncomms15983…”
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Putting the BRK on breast cancer: From molecular target to therapeutics by Ang, Hui Li, Yuan, Yi, Lai, Xianning, Tan, Tuan Zea, Wang, Lingzhi, Huang, Benjamin BoJun, Pandey, Vijay, Huang, Ruby Yun-Ju, Lobie, Peter E, Goh, Boon Cher, Sethi, Gautam, Yap, Celestial T, Chan, Ching Wan, Lee, Soo Chin, Kumar, Alan Prem

“…BReast tumor Kinase (BRK, also known as PTK6) is a non-receptor tyrosine kinase that is highly expressed in breast carcinomas while having low expression in…”
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Suppression of chromosome healing and anticheckpoint pathways in yeast postsenescence survivors by Lai, Xianning, Heierhorst, Jörg

“…Telomere repeat-like sequences at DNA double-strand breaks (DSBs) inhibit DNA damage signaling and serve as seeds to convert DSBs to new telomeres in mutagenic…”
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Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance by Tacconi, Eliana MC, Badie, Sophie, De Gregoriis, Giuliana, Reisländer, Timo, Lai, Xianning, Porru, Manuela, Folio, Cecilia, Moore, John, Kopp, Arnaud, Baguña Torres, Júlia, Sneddon, Deborah, Green, Marcus, Dedic, Simon, Lee, Jonathan W, Batra, Ankita Sati, Rueda, Oscar M, Bruna, Alejandra, Leonetti, Carlo, Caldas, Carlos, Cornelissen, Bart, Brino, Laurent, Ryan, Anderson, Biroccio, Annamaria, Tarsounas, Madalena

“…Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour…”
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Genomic stability disorders: from budding yeast to humans by Hoch, Nicolas Carlos, Lai, Xianning, Heierhorst, Jörg

“…Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance…”
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BRCA 1 and BRCA 2 tumor suppressors protect against endogenous acetaldehyde toxicity by Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena

“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous…”
Get full text

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance by Tacconi, Eliana Mc, Badie, Sophie, De Gregoriis, Giuliana, Reisländer, Timo, Lai, Xianning, Porru, Manuela, Folio, Cecilia, Moore, John, Kopp, Arnaud, Baguña Torres, Júlia, Sneddon, Deborah, Green, Marcus, Dedic, Simon, Lee, Jonathan W, Batra, Ankita Sati, Rueda, Oscar M, Bruna, Alejandra, Leonetti, Carlo, Caldas, Carlos, Cornelissen, Bart, Brino, Laurent, Ryan, Anderson, Biroccio, Annamaria, Tarsounas, Madalena

“…Due to compromised homologous recombination (HR) repair, and mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression…”
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Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responses by Lai, Xianning, Beilharz, Traude, Au, Wei-Chun, Hammet, Andrew, Preiss, Thomas, Basrai, Munira A, Heierhorst, Jörg

“…During its natural life cycle, budding yeast (Saccharomyces cerevisiae) has to adapt to drastically changing environments, but how environmental-sensing…”
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