Search Results - "Lai, Tsz Chung"

Maximum Penalized Likelihood Kernel Regression for Fast Adaptation by Mak, B.K.-W., Tsz-Chung Lai, Tsang, I.W., Kwok, J.T.-Y.

“…This paper proposes a nonlinear generalization of the popular maximum-likelihood linear regression (MLLR) adaptation algorithm using kernel methods. The…”
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Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin by Shin, Ho-Chul, Cho, Hyunah, Lai, Tsz Chung, Kozak, Kevin R., Kolesar, Jill M., Kwon, Glen S.

“…Concurrent delivery of multiple poorly water-soluble anticancer drugs has been a great challenge due to the toxicities exerted by different surfactants or…”
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Bioreducible polyether-based pDNA ternary polyplexes: Balancing particle stability and transfection efficiency by Lai, Tsz Chung, Kataoka, Kazunori, Kwon, Glen S.

“…[Display omitted] ► Ternary polyionic complexes with surface covered with different ratios of PEG and P(EPE) polymers were prepared. ► Colloidal stability of…”
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Polymeric Micelles for Multi-Drug Delivery in Cancer by Cho, Hyunah, Lai, Tsz Chung, Tomoda, Keishiro, Kwon, Glen S.

“…Drug combinations are common in cancer treatment and are rapidly evolving, moving beyond chemotherapy combinations to combinations of signal transduction…”
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Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: Evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer by Cho, Hyunah, Lai, Tsz Chung, Kwon, Glen S.

“…Ovarian cancer is the most lethal gynecological malignancy, characterized by a high rate of chemoresistance. Current treatment strategies for ovarian cancer…”
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pH- and ion-sensitive polymers for drug delivery by Yoshida, Takayuki, Lai, Tsz Chung, Kwon, Glen S, Sako, Kazuhiro

“…Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely…”
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pH-Sensitive Multi-PEGylated Block Copolymer as a Bioresponsive pDNA Delivery Vector by Lai, Tsz Chung, Bae, Younsoo, Yoshida, Takayuki, Kataoka, Kazunori, Kwon, Glen S

“…Purpose A reversibly-PEGylated diblock copolymer, poly(aspartate-hydrazide-poly(ethylene glycol))-block-poly(aspartate-diaminoethane)…”
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Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency by Lai, Tsz Chung, Kataoka, Kazunori, Kwon, Glen S

“…Abstract PEGylated cationic polymers have been extensively studied for substituting virus as gene delivery vehicles. These polymers can produce water-soluble…”
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pH-Sensitive Multi-PEGylated Block Copolymer as a Bioresponsive pDNA Delivery Vector : Multifunctional Polymeric Carriers for Gene and Drug Delivery by TSZ CHUNG LAI, BAE, Younsoo, YOSHIDA, Takayuki, KATAOKA, Kazunori, KWON, Glen S

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Polyionic complexes from cationic block copolymers and plasmid DNA for gene delivery by Lai, Tsz Chung

“…Despite the high transfection efficiency of viral vectors, safety concerns hamper their progress in gene therapy clinical trials. As a safer alternative,…”
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Improving Reference Speaker Weighting Adaptation by the Use of Maximum-Likelihood Reference Speakers by Mak, B., Tsz-Chung Lai, Hsiao, R.

“…We would like to revisit a simple fast adaptation technique called reference speaker weighting (RSW). RSW is similar to eigenvoice (EV) adaptation, and simply…”
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Polyionic complexes from cationic block copolymers and plasmid DNA for gene delivery by Lai, Tsz Chung

“…Despite the high transfection efficiency of viral vectors, safety concerns hamper their progress in gene therapy clinical trials. As a safer alternative,…”
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