Search Results - "Lai, P L"

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes by Leithner, Alexander, Eichner, Alexander, Müller, Jan, Reversat, Anne, Brown, Markus, Schwarz, Jan, Merrin, Jack, de Gorter, David J. J., Schur, Florian, Bayerl, Jonathan, de Vries, Ingrid, Wieser, Stefan, Hauschild, Robert, Lai, Frank P. L., Moser, Markus, Kerjaschki, Dontscho, Rottner, Klemens, Small, J. Victor, Stradal, Theresia E. B., Sixt, Michael

“…By modulating the presence of lamellipodia and filopodia, Sixt and colleagues determine that migrating dendritic cells rely on these protrusions for directed…”
Get full text

Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation by Li, M-Y, Lai, P-L, Chou, Y-T, Chi, A-P, Mi, Y-Z, Khoo, K-H, Chang, G-D, Wu, C-W, Meng, T-C, Chen, G-C

“…Epidermal growth factor receptor (EGFR) regulates multiple signaling cascades essential for cell proliferation, growth and differentiation. Using a genetic…”
Get full text

Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model by Wang, C Y, Hsieh, M K, Hu, Y J, Bit, A, Lai, P L

“…During intervertebral disc degeneration (IVDD), due to endplate calcification, diminished oxygen and nutrient concentrations and accumulated lactate are…”
Get full text

C‐reactive protein gene polymorphism predicts the risk of thromboembolic stroke in patients with atrial fibrillation: a more than 10‐year prospective follow‐up study by Chang, S.‐N., Lai, L.‐P., Chiang, F.‐T., Lin, J.‐L., Hwang, J.‐J., Tsai, C.‐T.

“…Essentials We studied the C‐reactive protein (CRP) gene on stroke risk in atrial fibrillation (AF) patients. 725 patients with CRP triallelic polymorphism…”
Get full text

Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis by Wen, Z-H, Su, Y-C, Lai, P-L, Zhang, Y, Xu, Y-F, Zhao, A, Yao, G-Y, Jia, C-H, Lin, J, Xu, S, Wang, L, Wang, X-K, Liu, A-L, Jiang, Y, Dai, Y-F, Bai, X-C

“…The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers. Arachidonic acid (AA) and its metabolites play…”
Get full text

Arp2/3 complex interactions and actin network turnover in lamellipodia by Lai, Frank PL, Szczodrak, Malgorzata, Block, Jennifer, Faix, Jan, Breitsprecher, Dennis, Mannherz, Hans G, Stradal, Theresia EB, Dunn, Graham A, Small, J Victor, Rottner, Klemens

“…Cell migration is initiated by lamellipodia—membrane‐enclosed sheets of cytoplasm containing densely packed actin filament networks. Although the molecular…”
Get full text

Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src by Biosse Duplan, Martin, Zalli, Detina, Stephens, Sebastien, Zenger, Serhan, Neff, Lynn, Oelkers, J. Margit, Lai, Frank P. L., Horne, William, Rottner, Klemens, Baron, Roland

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A functional variant in the promoter region regulates the C-reactive protein gene and is a potential candidate for increased risk of atrial fibrillation by Chang, S.-N., Tsai, C.-T., Wu, C.-K., Lee, J.-K., Lai, L.-P., Huang, S.-W., Huang, L.-Y., Tseng, C.-D., Lin, J.-L., Chiang, F.-T., Hwang, J.-J.

“…  Chang S‐N, Tsai C‐T, Wu C‐K, Lee J‐K, Lai L‐P, Huang S‐W, Huang L‐Y, Tseng C‐D, Lin J‐L, Chiang F‐T, Hwang J‐J (National Taiwan University Hospital Yun‐Lin…”
Get full text

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes by Carlier, Marie-France, Scita, Giorgio, Innocenti, Metello, Gerboth, Silke, Rottner, Klemens, Lai, Frank P. L, Hertzog, Maud, Stradal, Theresia E. B, Frittoli, Emanuela, Didry, Dominique, Polo, Simona, Disanza, Andrea, Benesch, Stefanie, Fiore, Pier Paolo Di

“…Neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE are members of a family of proteins that use the Arp2/3 complex to stimulate actin assembly in…”
Get full text

Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma by Yuan, R-H, Jeng, Y-M, Chen, H-L, Lai, P-L, Pan, H-W, Hsieh, F-J, Lin, C-Y, Lee, P-H, Hsu, H-C

“…Stathmin, a major microtubule‐depolymerizing protein, is involved in cell cycle progression and cell motility. This study aimed to elucidate its role in the…”
Get full text

Kernel and nonlinear canonical correlation analysis by Lai, P L, Fyfe, C

“…We review a neural implementation of the statistical technique of Canonical Correlation Analysis (CCA) and extend it to nonlinear CCA. We then derive the…”
Get more information

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits by Benesch, Stefanie, Polo, Simona, Lai, Frank P. L, Anderson, Kurt I, Stradal, Theresia E. B, Wehland, Juergen, Rottner, Klemens

“…WASP and WAVE family proteins promote actin polymerization by stimulating Arp2/3-complex-dependent filament nucleation. Unlike WAVE proteins, which are known…”
Get full text

Preoperative plasma N-terminal pro-brain natriuretic peptide as a marker of cardiac risk in patients undergoing elective non-cardiac surgery by Yeh, H.-M., Lau, H.-P., Lin, J.-M., Sun, W.-Z., Wang, M.-J., Lai, L.-P.

“…Background: Plasma N‐terminal pro‐brain natriuretic peptide (NTproBNP) is a sensitive marker for heart failure. This study tested whether the preoperative…”
Get full text

Overexpression of tumour-associated trypsin inhibitor (TATI) enhances tumour growth and is associated with portal vein invasion, early recurrence and a stage-independent prognostic factor of hepatocellular carcinoma by Lee, Y.-C, Pan, H.-W, Peng, S.-Y, Lai, P.-L, Kuo, W.-S, Ou, Y.-H, Hsu, H.-C

“…Abstract Tumour-associated trypsin inhibitor (TATI) overexpresses in various tumours, but its clinicopathological significance in hepatocellular carcinoma…”
Get full text

Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and currently available drugs by Gasparini, R, Amicizia, D, Lai, P L, Bragazzi, N L, Panatto, D

“…Influenza is a contagious respiratory acute viral disease characterized by a short incubation period, high fever and respiratory and systemic symptoms. The…”
Get full text

How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by Amicizia, D., Levi, M., Bechini, A., Lai, P. L., Bragazzi, Nicola Luigi, Panatto, D., Gasparini, R., Durando, Paolo

“…In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved,…”
Get full text

Renin-angiotensin system gene polymorphisms and diastolic heart failure by Wu, C.-K., Tsai, C.-T., Hwang, J.-J., Luo, J.-L., Juang, J. J.-M., Hsu, K.-L., Lai, L.-P., Lin, J.-L., Tseng, C.-D., Chiang, F.-T.

“…ABSTRACT Background  Diastolic heart failure (DHF) refers to an abnormality of diastolic distensibility, filling or relaxation of the left ventricle. The…”
Get full text

New versus old meningococcal group B vaccines: how the new ones may benefit infants & toddlers by Panatto, D, Amicizia, D, Lai, P L, Cristina, M L, Domnich, A, Gasparini, R

“…Invasive disease caused by Neisseria meningitidis is associated with high mortality and high disability rates and mainly affects children under one year of…”
Get full text

A neural implementation of canonical correlation analysis by Lai, P.L, Fyfe, C

“…We derive a new method of performing Canonical Correlation Analysis with Artificial Neural Networks. We demonstrate the network's capabilities on artificial…”
Get full text

Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis by Lin, T-Y, Cheng, Y-C, Yang, H-C, Lin, W-C, Wang, C-C, Lai, P-L, Shieh, S-Y

“…The B-cell translocation gene 3 ( BTG3 ) is a member of the antiproliferative BTG gene family and a downstream target of p53. BTG3 also binds and inhibits…”
Get full text