Search Results - "Lai, N. Chin"

Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice by Lew, Wilbur Y W, Bayna, Evelyn, Molle, Erminia Dalle, Dalton, Nancy D, Lai, N Chin, Bhargava, Valmik, Mendiola, Vincent, Clopton, Paul, Tang, Tong

“…Circulating subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting high fatty meals increases LPS that cause metabolic endotoxemia…”
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Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice by Kim, Young Chul, Giamouridis, Dimosthenis, Lai, N Chin, Guo, Tracy, Xia, Bing, Fu, Zhenxing, Gao, Mei Hua, Hammond, H Kirk

“…Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated…”
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Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain ( C1C2 ) Attenuates Deleterious Effects of Pressure Overload by Tan, Zhen, Giamouridis, Dimosthenis, Lai, N Chin, Kim, Young Chul, Guo, Tracy, Xia, Bing, Gao, Mei Hua, Hammond, H Kirk

“…A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6) retains beneficial effects of AC6…”
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Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance by Kim, Young Chul, Truax, Agnieszka D, Giamouridis, Dimosthenis, Lai, N Chin, Guo, Tracy, Hammond, H Kirk, Gao, Mei Hua

“…Urocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector…”
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Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice by Giamouridis, Dimosthenis, Gao, Mei Hua, Lai, N. Chin, Guo, Tracy, Miyanohara, Atsushi, Blankesteijn, W. Matthijs, Biessen, Erik A.L., Hammond, H. Kirk

“…Prevalence of left ventricular (LV) systolic and diastolic dysfunction increases with aging. We previously reported that urocortin 2 (Ucn2) gene transfer…”
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The Cyclic AMP Effector Epac Integrates Pro- and Anti-Fibrotic Signals by Yokoyama, Utako, Patel, Hemal H., Lai, N. Chin, Aroonsakool, Nakon, Roth, David M., Insel, Paul A.

“…Scar formation occurs during the late stages of the inflammatory response but, when excessive, produces fibrosis that can lead to functional and structural…”
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Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice by Lai, N Chin, Gao, Mei Hua, Tang, Eric, Tang, Ruoying, Guo, Tracy, Dalton, Nancy D, Deng, Aihua, Tang, Tong

“…Congestive heart failure is associated with increased expression of pro-inflammatory cytokines, and the levels of these cytokines correlate with heart failure…”
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Spiracular air breathing in polypterid fishes and its implications for aerial respiration in stem tetrapods by Graham, Jeffrey B., Wegner, Nicholas C., Miller, Lauren A., Jew, Corey J., Lai, N Chin, Berquist, Rachel M., Frank, Lawrence R., Long, John A.

“…The polypterids (bichirs and ropefish) are extant basal actinopterygian (ray-finned) fishes that breathe air and share similarities with extant lobe-finned…”
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Human Oxidation-Specific Antibodies Reduce Foam Cell Formation and Atherosclerosis Progression by Tsimikas, Sotirios, MD, Miyanohara, Atsushi, PhD, Hartvigsen, Karsten, PhD, Merki, Esther, PhD, Shaw, Peter X., PhD, Chou, Meng-Yun, PhD, Pattison, Jennifer, BA, Torzewski, Michael, MD, Sollors, Janina, Friedmann, Theodore, MD, Lai, N. Chin, PhD, Hammond, H. Kirk, MD, Getz, Godfrey S., MD, PhD, Reardon, Catherine A., PhD, Li, Andrew C., MD, Banka, Carole L., PhD, Witztum, Joseph L., MD

“…Objectives We sought to assess the in vivo importance of scavenger receptor (SR)–mediated uptake of oxidized low-density lipoprotein (OxLDL) in atherogenesis…”
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Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation by Gao, Mei Hua, Lai, N Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Guo, Tracy, Hammond, H Kirk

“…Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and…”
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Adenylyl Cyclase Type 6 Deletion Decreases Left Ventricular Function via Impaired Calcium Handling by TONG TANG, MEI HUA GAO, CHIN LAI, N, FIRTH, Amy L, TAKAHASHI, Toshiyuki, GUO, Tracy, YUAN, Jason X.-J, ROTH, David M, KIRK HAMMOND, H

“…Adenylyl cyclases (ACs) are a family of effector molecules for G-protein-coupled receptors. The 2 ACs most abundantly expressed in cardiac myocytes are types 5…”
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G-protein-coupled Receptor Signaling Components Localize in Both Sarcolemmal and Intracellular Caveolin-3-associated Microdomains in Adult Cardiac Myocytes by Head, Brian P., Patel, Hemal H., Roth, David M., Lai, N. Chin, Niesman, Ingrid R., Farquhar, Marilyn G., Insel, Paul A.

“…This study tests the hypothesis that G-protein-coupled receptor (GPCR) signaling components involved in the regulation of adenylyl cyclase (AC) localize with…”
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Activation of Cardiac Adenylyl Cyclase Expression Increases Function of the Failing Ischemic Heart in Mice by Lai, N. Chin, PhD, Tang, Tong, PhD, Gao, Mei Hua, PhD, Saito, Miho, MD, Takahashi, Toshiyuki, MD, PhD, Roth, David M., MD, PhD, Hammond, H. Kirk, MD

“…Activation of Cardiac Adenylyl Cyclase Expression Increases Function of the Failing Ischemic Heart in Mice N. Chin Lai, Tong Tang, Mei Hua Gao, Miho Saito,…”
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Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency by Gao, Mei Hua, Giamouridis, Dimosthenis, Lai, N. Chin, Guo, Tracy, Xia, Bing, Kim, Young Chul, Huu, Viet Anh Nguyen, Skowronska-Krawczyk, Dorota, Lantier, Louise, Bhargava, Raag, Hammond, H. Kirk

“…Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of…”
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Clinical Evaluation of Heart Failure: Agreement among Tests by Pandey, Amit K, Penny, William F, Bhargava, Valmik, Lai, N Chin, Xu, Ronghui, Hammond, H Kirk

“…Methods commonly used clinically to assess cardiac function in patients with heart failure include ejection fraction (EF), exercise treadmill testing (ETT),…”
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Adenylyl Cyclase 6 Improves Calcium Uptake and Left Ventricular Function in Aged Hearts by Tang, Tong, PhD, Hammond, H. Kirk, MD, Firth, Amy, PhD, Yang, Yuan, MD, Gao, Mei Hua, PhD, Yuan, Jason X.-J., MD, PhD, Lai, N. Chin, PhD

“…Objectives This study tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes improves calcium uptake and left…”
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Adenylyl Cyclase 6 Deletion Reduces Left Ventricular Hypertrophy, Dilation, Dysfunction, and Fibrosis in Pressure-Overloaded Female Mice by Tang, Tong, PhD, Lai, N. Chin, PhD, Hammond, H. Kirk, MD, Roth, David M., MD, PhD, Yang, Yuan, MD, Guo, Tracy, BS, Gao, Mei Hua, PhD

“…Objectives This study sought to test the hypothesis that pressure stress of the adenylyl cyclase 6-deleted (AC6-KO) heart would result in excessive…”
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Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal by Giamouridis, Dimosthenis, BS, MS, Gao, Mei Hua, PhD, Lai, N. Chin, PhD, Tan, Zhen, PhD, Kim, Young Chul, PhD, Guo, Tracy, BS, Miyanohara, Atsushi, PhD, Blankesteijn, W. Matthijs, PhD, Biessen, Erik, PhD, Hammond, H. Kirk, MD

“…Visual Abstract…”
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Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure by Lai, N Chin, Roth, David M, Gao, Mei Hua, Tang, Tong, Dalton, Nancy, Lai, Yin Yin, Spellman, Matthew, Clopton, Paul, Hammond, H Kirk

“…We tested the hypothesis that intracoronary delivery of an adenovirus encoding adenylyl cyclase type VI (Ad.AC(VI)) would be associated with increased left…”
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Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice by Gao, Mei Hua, Lai, N Chin, Miyanohara, Atsushi, Schilling, Jan M, Suarez, Jorge, Tang, Tong, Guo, Tracy, Tang, Ruoying, Parikh, Jay, Giamouridis, Dimosthenis, Dillmann, Wolfgang H, Patel, Hemal H, Roth, David M, Dalton, Nancy D, Hammond, H Kirk

“…Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, costly, and provides…”
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