Search Results - "Lai, Luying"

KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity by Li, Hui, Weng, Yaqian, Lai, Luying, Lei, Hongyi, Xu, Shiyuan, Zhang, Yang, Li, Le

“…Background Neurotoxicity induced by local anesthetics (LAs) is potentially life threatening, especially for patients with underlying diseases like diabetes…”
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Role of mitochondrial Ca2+ uniporter in remifentanil‐induced postoperative allodynia by Lu, Aizhu, Lei, Hongyi, Li, Le, Lai, Luying, Liang, Wenbin, Xu, Shiyuan

“…Opioid‐induced hyperalgesia (OIH) and allodynia is a well‐known phenomenon and refers to the pain sensitization in patients after prolonged opioid exposure…”
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Effect of dexmedetomidine administration on analgesic, respiration and inflammatory responses in patients undergoing percutaneous endoscopic lumbar discectomy: a prospective observational study by Zhang, Xiaoli, Zhao, Wenping, Sun, Cong, Huang, Zhihua, Zhan, Lifang, Xiao, Chunlin, Lai, Luying, Shan, Reai

“…Local anesthesia has been recommended for percutaneous endoscopic lumbar discectomy (PELD) in recent years; however, the efficacy, including oxidative stress,…”
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Bupivacaine Induces ROS-Dependent Autophagic Damage in DRG Neurons via TUG1/mTOR in a High-Glucose Environment by Lai, Luying, Wang, Yongwei, Peng, Shenghui, Guo, Wenjing, Wei, Guanshan, Li, Le, Xia, Zhengyuan, Li, Fengxian, Xu, Shiyuan

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A Neuron–Mast Cell Axis Regulates Skin Microcirculation in Diabetes by Li, Xinran, Yuan, Dan, Zhang, Peng, Luo, Chenglei, Xie, Xinyang, Zhang, Yue, Wei, Zhengqi, Wang, Mingyang, Cai, Yunqiu, Zeng, Yi, Lai, Luying, Che, Delu, Ling, Hao, Shi, Shengjun, Zhang, Hong-Fei, Wang, Fang, Li, Fengxian

“…Changes in microcirculation lead to the progression of organ pathology in diabetes. Although neuroimmune interactions contribute to a variety of conditions, it…”
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Bupivacaine Induces ROS-Dependent Autophagic Damage in DRG Neurons via TUG1/mTOR in a High-Glucose Environment by Lai, Luying, Wang, Yongwei, Peng, Shenghui, Guo, Wenjing, Wei, Guanshan, Li, Le, Xia, Zhengyuan, Li, Fengxian, Xu, Shiyuan

“…Bupivacaine (BP) is a commonly clinically used local anesthetic (LA). Current studies suggest that neurological complications are increased in diabetic…”
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The roles of PARP-1 and XPD and their potential interplay in repairing bupivacaine-induced neuron oxidative DNA damage by Zhao, Wei, Liu, Zhongjie, Luo, Jiaming, Ma, Changqing, Lai, Luying, Xia, Zhengyuan, Xu, Shiyuan

“…Bupivacaine has been widely used in clinical Anesthesia, but its neurotoxicity has been frequently reported, implicating cellular oxidative DNA damage as the…”
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P53 and taurine upregulated gene 1 promotes the repair of the DeoxyriboNucleic Acid damage induced by bupivacaine in murine primary sensory neurons by Lai, Luying, Wang, Yongwei, Peng, Shenghui, Guo, Wenjing, Li, Fengxian, Xu, Shiyuan

“…The research aimed to explore the biological role of p53 protein and long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in bupivacaine…”
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The DNA Repair Enzyme XPD Is Partially Regulated by PI3K/AKT Signaling in the Context of Bupivacaine-Mediated Neuronal DNA Damage by Zhao, Wei, Zeng, Lei, Luo, Jiaming, Li, Ji, Lai, Luying, Xu, Shiyuan, Liu, Zhongjie

“…Bupivacaine, a local anesthetic widely used for regional anesthesia and pain management, has been reported to induce neuronal injury, especially DNA damage…”
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Role of mitochondrial Ca 2+ uniporter in remifentanil-induced postoperative allodynia by Lu, Aizhu, Hongyi, Lei, Li, Le, Lai, Luying, Liang, Wenbin, Xu, Shiyuan

“…Opioid-induced hyperalgesia and allodynia (OIH) is a well-known phenomenon and refers to the pain sensitization in patients after prolonged opioid exposure…”
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Inhibition of Ku70 in a high-glucose environment aggravates bupivacaine-induced dorsal root ganglion neurotoxicity by Wang, Yongwei, Lai, Luying, Guo, Wenjing, Peng, Shenghui, Liu, Ruimeng, Hong, Pu, Wei, Guanshan, Li, Fengxian, Jiang, Shan, Wang, Pei, Li, Ji, Lei, Hongyi, Zhao, Wei, Xu, Shiyuan

“…•High glucose causes an increase in cell toxicity induced by BP.•High glucose aggravated BP-induced DNA damage and apoptosis.•High glucose aggravated…”
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iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways by Zhao, Wei, Liu, Zhongjie, Yu, Xujiao, Lai, Luying, Li, Haobo, Liu, Zipeng, Li, Le, Jiang, Shan, Xia, Zhengyuan, Xu, Shi-yuan

“…Bupivacaine, a commonly used local anesthetic, has potential neurotoxicity through diverse signaling pathways. However, the key mechanism of…”
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A neural-mast cell axis regulates skin microcirculation in diabetes by Li, Xinran, Yuan, Dan, Zhang, Peng, Luo, Chenglei, Xie, Xinyang, Zhang, Yue, Wei, Zhengqi, Wang, Mingyang, Cai, Yunqiu, Zeng, Yi, Lai, Luying, Che, Delu, Ling, Hao, Shi, Shengjun, Zhang, Hong-Fei, Wang, Fang, Li, Fengxian

“…Changes in microcirculation lead to the progression of organ pathology in diabetes. Although neuroimmune interactions contribute to a variety of conditions, it…”
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Increased Oxidative Damage and Reduced DNA Repair Enzyme XPD Involvement in High Glucose-Mediated Enhancement of Levobupivacaine-Induced Neurotoxicity by Liu, ZhongJie, Zhao, Wei, Zhang, QingGuo, Lai, LuYing, Jiang, Shan, Zhang, Jing, Xu, ShiYuan

“…Levobupivacaine is one of the major clinical local anesthetics, but it can cause neuron toxic damage. Hyperglycemia can cause neuronal DNA oxidative damage and…”
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Cytotoxicity study on SH-SY5Y cells cultured at high glucose levels and treated with bupivacaine by LI, YAWEN, XU, SHIYUAN, ZHANG, QINGGUO, LI, LE, LAI, LUYING, ZHENG, TING, SU, JIAOLING, YANG, NAIMEI, LI, YUANTAO

“…The aim of this study was to investigate susceptibility to the neurotoxicity of local anesthetic agents in a model of gestational diabetes mellitus (GDM)…”
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